Primary unilateral adrenal hyperplasia
diseaseOn this page
Also known as PUAH
Summary
Primary unilateral adrenal hyperplasia (MONDO:0016504) is a disease. A subtype of primary aldosteronism — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Worldwide)
- Phenotypes (HPO): 15
Clinical features
Signs & symptoms
Clinical features (HPO)
15 HPO clinical features (Orphanet curated; top 15 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0000822 | Hypertension | Obligate (100%) |
| HP:0003351 | Decreased circulating renin concentration | Obligate (100%) |
| HP:0011740 | Glucocortocoid-insensitive primary hyperaldosteronism | Obligate (100%) |
| HP:0002900 | Hypokalemia | Frequent (30-79%) |
| HP:0003081 | Increased urinary potassium | Frequent (30-79%) |
| HP:0008221 | Adrenal hyperplasia | Frequent (30-79%) |
| HP:0200114 | Metabolic alkalosis | Frequent (30-79%) |
| HP:0000360 | Tinnitus | Occasional (5-29%) |
| HP:0000421 | Epistaxis | Occasional (5-29%) |
| HP:0001324 | Muscle weakness | Occasional (5-29%) |
| HP:0001959 | Polydipsia | Occasional (5-29%) |
| HP:0001962 | Palpitations | Occasional (5-29%) |
| HP:0002018 | Nausea | Occasional (5-29%) |
| HP:0002315 | Headache | Occasional (5-29%) |
| HP:0003394 | Muscle spasm | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | primary unilateral adrenal hyperplasia |
| Mondo ID | MONDO:0016504 |
| Orphanet | 231580 |
| ICD-11 | 1653668765 |
| SNOMED CT | 715868005 |
| UMLS | C4274967 |
| MedGen | 905007 |
| GARD | 0020620 |
| Is cancer (heuristic) | no |
Also known as: PUAH
Disease family
This is a subtype of primary aldosteronism. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › endocrine system disorder › adrenal gland disorder › adrenal cortex disorder › adrenal gland hyperfunction › hyperaldosteronism › primary aldosteronism › primary unilateral adrenal hyperplasia
Related subtypes (3): aldosterone-producing adrenal cortex adenoma, ectopic aldosterone-producing tumor, familial hyperaldosteronism
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.