Proctosigmoiditis

Summary

Proctosigmoiditis (MONDO:0021736) is a disease and 5 clinical trials. Top therapeutic interventions include budesonide. A subtype of proctocolitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 5

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	proctosigmoiditis
Mondo ID	MONDO:0021736
NCIT	C34950
SNOMED CT	41364008
UMLS	C0033252
MedGen	18653
Is cancer (heuristic)	no

Also known as: proctosigmoiditis · Rectosigmoiditis

Disease family

Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › gastroenteritis › colitis › proctocolitis › proctosigmoiditis

Related subtypes (1): food protein-induced allergic proctocolitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 5.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE3	3
PHASE2	1
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01008410	PHASE3	COMPLETED	Efficacy and Safety of Budesonide Foam for Participants With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis
NCT01008423	PHASE3	COMPLETED	Efficacy and Safety of Budesonide Foam for Participants With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis
NCT01349673	PHASE3	TERMINATED	The Safety and Tolerability of Budesonide Foam in Participants With Active Ulcerative Proctitis or Proctosigmoiditis
NCT01149707	PHASE2	COMPLETED	Safety, Tolerability, Efficacy Study of PUR 0110 Rectal Enema in Mild-to-Moderate Distal Ulcerative Colitis
NCT05817266	Not specified	WITHDRAWN	Role of FCI in the Detection of Proctosigmoiditis Caused by IBD

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
BUDESONIDE	4	3