Progestogen hypersensitivity

Summary

Progestogen hypersensitivity (MONDO:0021952) is a disease and 13 clinical trials. Top therapeutic interventions include water, icodextrin, and physioneal. A subtype of hypersensitivity reaction disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 13

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	progestogen hypersensitivity
Mondo ID	MONDO:0021952
MeSH	C535299
SNOMED CT	400009001
UMLS	C1260879
MedGen	220359
Is cancer (heuristic)	no

Also known as: APD · autoimmune progesterone dermatitis · autoimmune progesterone dermatitis/urticaria · autoimmune progesterone urticaria · PH · progesterone dermatitis

Disease family

This is a subtype of hypersensitivity reaction disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › immune system disorder › hypersensitivity reaction disease › progestogen hypersensitivity

Related subtypes (9): type IV hypersensitivity disease, allergic disease, hypersensitivity vasculitis, type III hypersensitivity disease, IgE responsiveness, atopic, immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome, type II hypersensitivity reaction disease, pseudoallergy, anaphylaxis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 13.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	10
PHASE4	1
PHASE1/PHASE2	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00567489	PHASE4	COMPLETED	IMPENDIA- PEN VS Dianeal Only Improved Metabolic Control In Diabetic CAPD and APD Patients
NCT05852145	PHASE1/PHASE2	RECRUITING	Oral Changes With Caloric and no Caloric Sweeteners
NCT05437874	PHASE1	COMPLETED	Carbonated Beverage Consumption in pH and Bacterial Proliferation
NCT01338571	Not specified	COMPLETED	Horton & Maizy Pilot Study for Resistant to Starch
NCT03510962	Not specified	COMPLETED	Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Fruit Juice
NCT03513575	Not specified	COMPLETED	Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Flavoured Milk
NCT03526770	Not specified	COMPLETED	Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Carbonated Drink
NCT03612414	Not specified	COMPLETED	Efficacy of a Dietary Supplement (Aqualief®) in Xerostomic Patients
NCT03877874	Not specified	UNKNOWN	The Impact of Anti- Asthmatic Medications on Salivary pH and Dental Caries Pattern in a Group of Egyptian Children With Bronchial Asthma
NCT03934515	Not specified	COMPLETED	End-Tidal CO2 (etCO2) and pH in the Correct Naso-gastric Tube Placement
NCT04717778	Not specified	COMPLETED	Comparison of Salivary pH After Consuming Milk of Origin Vegetable vs Cow’s Milk in Children
NCT05746949	Not specified	COMPLETED	Comparison of the Effects of High-flow Nasal Cannula Oxygen and Jet Ventilation Techniques
NCT06122597	Not specified	COMPLETED	A Clinical Trial to Evaluate the Efficacy of ConcenTrace to Buffer pH Levels Within the Body.

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
WATER	4	2
ICODEXTRIN	4	1
PHYSIONEAL	3	1
STEVIOSIDE	1	1
CHEMBL4076687	0	1