Prosthesis-related infectious disease
diseaseOn this page
Also known as device related infectioninfections, prosthesis-relatedprosthesis related infectionsprosthesis-related infection
Summary
Prosthesis-related infectious disease (MONDO:0043892) is a disease and 32 clinical trials. Top therapeutic interventions include clavulanic acid, dalbavancin, and oxygen. A subtype of infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 32
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | prosthesis-related infectious disease |
| Mondo ID | MONDO:0043892 |
| MeSH | D016459 |
| NCIT | C79705 |
| Is cancer (heuristic) | no |
Also known as: device related infection · infections, prosthesis-related · prosthesis related infections · prosthesis-related infection
Disease family
This is a subtype of infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › prosthesis-related infectious disease
Related subtypes (34): infective endocarditis, hirudiniasis, fungal infectious disease, infectious peritonitis, epididymitis, viral infectious disease, bacterial infectious disease, parasitic infectious disease, abscess, Ciliophora infectious disease, hookworm infectious disease, infectious embryofetopathy, mycetoma, infectious disorder of the nervous system, ear infection, sexually transmitted disease, puerperal infection, Acanthamoeba infectious disease, infectious myositis, infective vaginitis, skin disorder caused by infection, respiratory tract infectious disorder, nail infection, infective arthritis, digestive system infectious disorder, nosocomial infection, eye infectious disorder, vector-borne disease, coinfection, urinary tract infection, hemorrhagic fever, protothecosis, pythiosis, infectious disease with sepsis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 32.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 25 |
| PHASE4 | 5 |
| PHASE3 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT07240649 | PHASE4 | NOT_YET_RECRUITING | Outcomes From Hyperbaric Oxygen (HBO2) Treatment for Emerging Indications |
| NCT07454096 | PHASE4 | NOT_YET_RECRUITING | Application of Radiomics for Diagnosis and Follow-up of Cardiovascular Device Infections: PREDICT Study |
| NCT07547826 | PHASE4 | NOT_YET_RECRUITING | Efficacy and Cost-Effectiveness of Topical Vancomycin Powder in Preventing Pediatric Ventriculoperitoneal Shunt Infections Across Different Etiologies |
| NCT00423982 | PHASE4 | UNKNOWN | Rifampin Combination Therapy Versus Monotherapy in Early Staphylococcal Infections After Total Hip and Knee Arthroplasty |
| NCT01175044 | PHASE4 | COMPLETED | Dilute Betadine Lavage in the Prevention of Postoperative Infection |
| NCT01816009 | PHASE3 | COMPLETED | Treatment of the Infections on Osteo-articular Prostheses by 6 Versus 12 Weeks of Antibiotherapy |
| NCT01337466 | PHASE1 | COMPLETED | Biodistribution and Dosimetry Evaluation of [124I]FIAU |
| NCT04016870 | Not specified | ACTIVE_NOT_RECRUITING | Project My Heart Your Heart: Pacemaker Reuse |
| NCT06521073 | Not specified | NOT_YET_RECRUITING | Educatıon in Patıents Who Had Total Knee Prosthesıs |
| NCT06591728 | Not specified | NOT_YET_RECRUITING | PCA Loading Time Before Knee Prosthetic Joint Infection Revision |
| NCT07019610 | Not specified | NOT_YET_RECRUITING | Chlorhexidine Caps for CLABSI Prevention in Hemodialysis: a Pilot Randomized Controlled Trial |
| NCT07264296 | Not specified | ENROLLING_BY_INVITATION | Implant-Related Infections in Patients With Skeletal Sarcomas |
| NCT07587593 | Not specified | NOT_YET_RECRUITING | The IVCare Adaptive Platform Trial |
| NCT01760863 | Not specified | COMPLETED | Oral Antibiotics After 2-Stage Revision for Infected Total Hip Arthroplasty and Total Knee Arthroplasty |
| NCT02127281 | Not specified | COMPLETED | Evaluation of Wound Management With Negative Pressure Dressing Versus Standard Dressing After Revision Arthroplasty. |
| NCT02376153 | Not specified | UNKNOWN | Air Barrier System for the Prevention of Prosthesis-related Infections |
| NCT02424903 | Not specified | UNKNOWN | European Prosthetic Joint Infection Cohort Study- Hip, Knee and Shoulder Prosthetic Joint Infection |
| NCT02860767 | Not specified | COMPLETED | Dosing of Antibiotics During Reimplantation of Infected Knee and Hip Prostheses |
| NCT03067909 | Not specified | COMPLETED | Antithrombotic Therapy in Patients Undergoing CIED Surgery - HEMATOMA NO MORE Registry |
| NCT03121183 | Not specified | UNKNOWN | Medico-economic Evaluation of Strategies for the Lead Extraction of Implantable Defibrillator and Pacemakers |
| NCT03274466 | Not specified | COMPLETED | Closed Incision Negative Pressure Therapy Versus Standard of Care Surgical Dressing in Revision Total Knee Arthroplasty |
| NCT03444571 | Not specified | UNKNOWN | PRO-DIAG: Improved Diagnosis of Prosthetic Joint Infections |
| NCT04304885 | Not specified | UNKNOWN | Effect of Sonication on Periprosthetic Joint Infection Treatment Strategy. |
| NCT04520841 | Not specified | UNKNOWN | Clinical Trial Comparing Negative Pressure Wound Therapy and Standard Dry Dressings |
| NCT04622280 | Not specified | COMPLETED | Prospectively Observational Evaluation of Clinical Outcomes in Two-stage Revision for Periprosthetic Knee Infection |
| NCT04736979 | Not specified | COMPLETED | Antibiotic PRophylAxis Based on infeCTIve Risk in Cardiac Implantable Electronic Device |
| NCT05113303 | Not specified | COMPLETED | COREV 2.0 PMCF-Study on Manual and Navigated Revision Knee Patients |
| NCT05582460 | Not specified | COMPLETED | Exploring Novel Diagnostic Tools for Periprosthetic Joint Infection |
| NCT05741866 | Not specified | COMPLETED | Novel Antimicrobial Dressing in Peripheral Intravenous Catheters (PIVCs) |
| NCT05867108 | Not specified | UNKNOWN | Contribution of the Sonication of Implants to the Diagnosis of Joint Prosthesis Infection: A Retrospective Cohort Study |
| NCT06089044 | Not specified | COMPLETED | Evaluation of the Efficacy and Safety of Suppressive Therapy With DALBAVANCINE in Device Infections |
| NCT06433700 | Not specified | COMPLETED | Risk of Revision Following Knee Arthroplasty in Bariatric Surgery Patients |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CLAVULANIC ACID | 4 | 1 |
| DALBAVANCIN | 4 | 1 |
| OXYGEN | 4 | 1 |
| POVIDONE-IODINE | 4 | 1 |
| SODIUM CHLORIDE | 4 | 1 |
| VANCOMYCIN | 4 | 1 |
| CHEMBL4299436 | 0 | 1 |
| CHEMBL4778239 | 0 | 1 |
| CHEMBL4785392 | 0 | 1 |
| CHEMBL6174705 | 0 | 1 |
| BENANSERIN HYDROCHLORIDE | -1 | 1 |