Pruritic urticarial papules and plaques of pregnancy

Summary

Pruritic urticarial papules and plaques of pregnancy (MONDO:0008353) is a disease. A subtype of urticaria — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide) [Orphanet-validated]
• Phenotypes (HPO): 21

Clinical features

Signs & symptoms

Clinical features (HPO)

21 HPO clinical features (Orphanet curated; top 21 by frequency):

HPO ID	Term	Frequency
HP:0000989	Pruritus	Very frequent (80-99%)
HP:0001065	Striae distensae	Very frequent (80-99%)
HP:0030350	Erythematous papule	Very frequent (80-99%)
HP:0030351	Urticarial plaque	Very frequent (80-99%)
HP:0001036	Parakeratosis	Frequent (30-79%)
HP:0004324	Increased body weight	Frequent (30-79%)
HP:0025474	Erythematous plaque	Frequent (30-79%)
HP:0030898	Pruritis on abdomen	Frequent (30-79%)
HP:0200037	Skin vesicle	Frequent (30-79%)
HP:0001041	Facial erythema	Occasional (5-29%)
HP:0030899	Pruritis on hand	Occasional (5-29%)
HP:0030900	Pruritus on foot	Occasional (5-29%)
HP:0031248	Palmar pruritus	Occasional (5-29%)
HP:0031538	Abnormal dermoepidermal junction morphology	Occasional (5-29%)
HP:0100872	Abnormality of the plantar skin of foot	Occasional (5-29%)
HP:0031540	Linear IgG deposits along the epidermal basement membrane zone	Excluded (0%)
HP:0031541	Linear C3 deposits along the epidermal basement membrane zone	Excluded (0%)
HP:0000964	Eczematoid dermatitis	Very rare (<1-4%)
HP:0008066	Abnormal blistering of the skin	Very rare (<1-4%)
HP:0025493	Palmoplantar erythema	Very rare (<1-4%)
HP:0030901	Pruritis on breast	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	pruritic urticarial papules and plaques of pregnancy
Mondo ID	MONDO:0008353
MeSH	C535817
OMIM	178995
Orphanet	64745
ICD-10-CM	O26.86
ICD-11	968694549
SNOMED CT	88697005
UMLS	C0269680
MedGen	78710
GARD	0009635
MedDRA	10066100
Is cancer (heuristic)	no

Also known as: polymorphic eruption of pregnancy · pruritic urticarial papules and plaques of pregnancy · pruritic urticarial papules and plaques of pregnancy, familial (subtype) · pruritic urticarial papules plaques of pregnancy · PUPPP

Disease family

This is a subtype of urticaria. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › integumentary system disorder › skin disorder › dermatitis › urticaria › pruritic urticarial papules and plaques of pregnancy

Related subtypes (13): allergic urticaria, physical urticaria, Melkersson-Rosenthal syndrome, urticaria, aquagenic, urticaria, familial localized heat, angioedema, drug rash with eosinophilia and systemic symptoms, cutaneous mastocytosis, cold urticaria, autoimmune urticaria, papular urticaria, idiopathic urticaria, chronic urticaria

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.