Pudendal neuralgia

disease

On this page

Also known as Alcock syndromeneuralgia of pudendal nervepudendal algiapudendal nerve entrapment syndromepudendal nerve neuralgiapudendal neuralgia by pudendal nerve entrapmentPudendalgia

Summary

Pudendal neuralgia (MONDO:0018957) is a disease and 14 clinical trials. Top therapeutic interventions include lidocaine. A subtype of acquired peripheral neuropathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

Prevalence: 1-5 / 10 000 (France) [Orphanet-validated]
Phenotypes (HPO): 19
Clinical trials: 14

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Point prevalence	1-5 / 10 000	16.67	France	Validated

Signs & symptoms

Clinical features (HPO)

19 HPO clinical features (Orphanet curated; top 19 by frequency):

HPO ID	Term	Frequency
HP:0012533	Allodynia	Very frequent (80-99%)
HP:0030016	Dyspareunia	Very frequent (80-99%)
HP:0030155	Scrotal pain	Very frequent (80-99%)
HP:0030943	Vulvodynia	Very frequent (80-99%)
HP:0032150	Paroxysmal rectal pain	Very frequent (80-99%)
HP:0033345	Neuralgia	Very frequent (80-99%)
HP:0100515	Pollakisuria	Very frequent (80-99%)
HP:0100518	Dysuria	Very frequent (80-99%)
HP:0100639	Erectile dysfunction	Very frequent (80-99%)
HP:0500005	Anal pain	Very frequent (80-99%)
HP:0034267	Pelvic pain	Frequent (30-79%)
HP:0034805	Buttock pain	Frequent (30-79%)
HP:0034806	Vaginal foreign body sensation	Frequent (30-79%)
HP:0000989	Pruritus	Excluded (0%)
HP:0001311	Abnormal nervous system electrophysiology	Excluded (0%)
HP:0003474	Somatic sensory dysfunction	Excluded (0%)
HP:0007379	Neoplasm of the genitourinary tract	Excluded (0%)
HP:0010787	Genital neoplasm	Excluded (0%)
HP:0030439	Anal canal adenocarcinoma	Excluded (0%)

Identifiers

Disease identifiers

Field	Value
Canonical name	pudendal neuralgia
Mondo ID	MONDO:0018957
MeSH	D060545
Orphanet	60039
ICD-11	1492963618
SNOMED CT	427972000
UMLS	C1997249
MedGen	372681
GARD	0010713
Anatomy (UBERON)	UBERON:0011390
Is cancer (heuristic)	no

Also known as: Alcock syndrome · neuralgia of pudendal nerve · pudendal algia · pudendal nerve entrapment syndrome · pudendal nerve neuralgia · pudendal neuralgia by pudendal nerve entrapment · Pudendalgia

Disease family

Classification path: disease › human disease › disease by body system or component › nervous system disorder › peripheral nervous system disorder › peripheral neuropathy › acquired peripheral neuropathy › pudendal neuralgia

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 14.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	11
PHASE4	2
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06644261	PHASE4	RECRUITING	Transvaginal Versus Fluoroscopy-guided Trans Gluteal Pudendal Nerve Block for Pudendal Neuralgia
NCT00851513	PHASE4	COMPLETED	Therapeutic Effects Analysis of Pudendal Nerve Infiltrations After 3 Months, in Patients Suffering of Pudendal Neuralgia
NCT06872437	PHASE3	RECRUITING	Evaluation of the Efficacy of Therapeutic Infiltrations of the Pudendal Nerve, Performed Under Neurostimulation on Pain, 1 Month After an Infiltration of Local Anaesthetic, in the Treatment of Pudendal Neuralgia.
NCT06413277	Not specified	RECRUITING	Targeting the Conus Medullaris With ECAP-Controlled Closed-Loop SCS for Treatment of Chronic Pelvic Pain: HOPE Trial
NCT06461312	Not specified	RECRUITING	Combined PRF of the Pudendal Nerve With Ganglion Impar Block Effectively Alleviates Pudendal Neuralgia
NCT06578767	Not specified	RECRUITING	Decompression of Pudendal and Inferior Cluneal Nerves Using Robot-assisted Laparoscopy for Entrapment Neuralgias : the X-DECO Study
NCT06796595	Not specified	RECRUITING	Perioperative Medical Program to Optimize Nerve Regeneration After Robot-assisted Laparoscopic Neurolyses of Pudendal and/or Inferior Cluneal Nerves for Chronic Neuralgias: Results After 1-year Follow-up
NCT07356102	Not specified	RECRUITING	Conventional Versus High-Voltage Long-Duration Pulsed Radiofrequency of the Pudendal Nerve
NCT02564172	Not specified	COMPLETED	Conus Medullaris Stimulation With 5 Columns Lead Versus Medical Treatment in Refractory Pudendal Neuralgia
NCT04198714	Not specified	COMPLETED	Pudendal Nerve Block in Vaginal Surgery
NCT04455659	Not specified	COMPLETED	Impact of Adding TENS to Conventional Physical Therapy Exercise on Pain Relief Among Patients With Pudendal Neuralgia.
NCT04509518	Not specified	COMPLETED	Effectiveness of Selected Physical Therapy Exercise Program and Transcutaneous Electrical Nerve Stimulation on Patients With Pudendal Neuralgia
NCT05531500	Not specified	UNKNOWN	Patient Reported Outcomes Following Interventional Procedures in Pelvic Pain
NCT07348952	Not specified	COMPLETED	Different Transcutaneous Electrical Nerve Stimulation Modes in Pudendal Neuralgia Post-prostatectomy

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
LIDOCAINE	4	1

Drugs: Lidocaine