Pulmonary valve insufficiency

Summary

Pulmonary valve insufficiency (MONDO:0001927) is a disease and 28 clinical trials. A subtype of pulmonary valve disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 28

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	pulmonary valve insufficiency
Mondo ID	MONDO:0001927
MeSH	D011665
DOID	DOID:14265
ICD-11	1093888988
NCIT	C50848
SNOMED CT	194995005
UMLS	C0034088
MedGen	11031
Is cancer (heuristic)	no

Also known as: pulmonary regurgitation · pulmonary valve regurgitation · pulmonary valvular regurgitation · regurgitation, pulmonary

Disease family

This is a subtype of pulmonary valve disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › heart disorder › heart valve disorder › pulmonary valve disorder › pulmonary valve insufficiency

Related subtypes (2): rheumatic pulmonary valve disease, pulmonary valve stenosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 28.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	25
PHASE4	1
PHASE3	1
PHASE2/PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06668389	PHASE4	RECRUITING	Sodium-Glucose Cotransporter 2 Inhibitors for Repaired Tetralogy of Fallot Patients for Enhancement of Cardio-Pulmonary Status Trial
NCT00259207	PHASE3	COMPLETED	Pulmonary Valve Replacement in Large Right Ventricular Outflow Tract
NCT02590679	PHASE2/PHASE3	UNKNOWN	Multi-center Trial of Percutaneous Pulmonary Valve Implantation With Venus-p
NCT02744677	Not specified	RECRUITING	COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction
NCT02979587	Not specified	ACTIVE_NOT_RECRUITING	The Medtronic Harmony™ Transcatheter Pulmonary Valve Clinical Study
NCT03130777	Not specified	ACTIVE_NOT_RECRUITING	ALTERRA: SAPIEN 3 THV With the Alterra Adaptive Prestent
NCT03441971	Not specified	ACTIVE_NOT_RECRUITING	Evaluation of the GORE PV1 Device in Patients With Pulmonary Valve Dysfunction
NCT03983512	Not specified	ACTIVE_NOT_RECRUITING	PULSTA Transcatheter Pulmonary Valve Pre-Approval Study
NCT04084132	Not specified	RECRUITING	Early Versus Later Re-valving in Tetralogy of Fallot With Free Pulmonary Regurgitation
NCT04570163	Not specified	RECRUITING	Berlin Registry of Right Heart Interventions
NCT04860765	Not specified	ACTIVE_NOT_RECRUITING	COMPASSION S3 Post-Approval Study
NCT05077774	Not specified	ACTIVE_NOT_RECRUITING	Harmony TPV Post-Approval Study
NCT05378386	Not specified	ACTIVE_NOT_RECRUITING	ALTERRA Post-Approval Study
NCT05809856	Not specified	RECRUITING	Feasibility Study to Evaluate the Safety of the Autologous GrOwnValve Transcatheter Pulmonary Heart Valve
NCT06010563	Not specified	RECRUITING	VenusP-Valve Pivotal Study (PROTEUS STUDY)
NCT06906926	Not specified	RECRUITING	Harmony TPV EMEA PMS
NCT00112320	Not specified	COMPLETED	Comparison of Two Pulmonary Valve Replacement Methods to Treat Tetralogy of Fallot
NCT00676689	Not specified	COMPLETED	COMPASSION - COngenital Multicenter Trial of Pulmonic VAlve Regurgitation Studying the SAPIEN InterventIONal THV
NCT01092442	Not specified	COMPLETED	CryoValve SG Pulmonary Human Heart Valve Post Clearance Study
NCT01356108	Not specified	COMPLETED	Pulmonic Valve REplacement Multi-discIpline EMEA Registry
NCT01824160	Not specified	COMPLETED	Pulmonary Artery Repair With Covered Stents
NCT02555319	Not specified	COMPLETED	A Feasibility Study to Evaluate the Safety and Short-term Effectiveness of Transcatheter Pulmonary Valve (TPV)
NCT02656290	Not specified	COMPLETED	COMMENCE Pulmonary: Clinical Evaluation of Edwards Pericardial Aortic Bioprosthesis (Model 11000A) for Pulmonary Valve Replacement
NCT02846753	Not specified	UNKNOWN	Implantation of the Venus P-Valve™ in the Pulmonic Position in Patients With Native Outflow Tracts
NCT02987387	Not specified	COMPLETED	COMPASSION XT PAS - Post-approval Study of the SAPIEN XT THV in Patients With Pulmonary Valve Dysfunction
NCT03471936	Not specified	UNKNOWN	Right Ventricular Diastolic Function in Chronic Adverse RV Loading And Congenital Heart Disease
NCT04205461	Not specified	UNKNOWN	Prospective Evaluation of Programmed Ventricular Stimulation Before Pulmonary Valve Replacement in Patients With Tetralogy of Fallot
NCT05090228	Not specified	COMPLETED	Right Ventricle Remodeling After Pulmonary Valve Replacement and Percutaneous Pulmonary Valve Insertion