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Atlas / Disease / Q fever

Q fever

disease
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Also known as Coxiella burnetii caused disease or disorderCoxiella burnetii disease or disorderCoxiella burnetii feverCoxiella burnetii infectious diseaseCoxiellosisinfection due to Coxiella burnetiinine Mile feverQ fever pneumoniaquadrilateral feverquery fever

Summary

Q fever (MONDO:0019186) is a disease and 10 clinical trials. Top therapeutic interventions include doxycycline anhydrous. A subtype of primary bacterial infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Prevalence: 1-9 / 1 000 000 (Europe) [Orphanet-validated]
  • Phenotypes (HPO): 62
  • Clinical trials: 10

Clinical features

Epidemiology

Prevalence records

23 prevalence record(s), Orphanet, top 20 (validated / broadest geography first):

TypeClassValueGeographyValidation
Annual incidence1-9 / 1 000 0000.16EuropeValidated
Annual incidence<1 / 1 000 0000.03United StatesValidated
Annual incidence1-9 / 100 0003AustraliaValidated
Annual incidence<1 / 1 000 0000.08BelgiumValidated
Annual incidence1-9 / 1 000 0000.26BulgariaValidated
Annual incidence1-9 / 1 000 0000.4CroatiaValidated
Annual incidence1-9 / 1 000 0000.32CyprusValidated
Annual incidence<1 / 1 000 0000.04FinlandValidated
Annual incidence1-9 / 1 000 0000.26FranceValidated
Annual incidence1-9 / 1 000 0000.26GermanyValidated
Annual incidence1-9 / 1 000 0000.1GreeceValidated
Annual incidence1-9 / 1 000 0000.64HungaryValidated
Annual incidence<1 / 1 000 0000.06IrelandValidated
Annual incidence<1 / 1 000 0000.07LatviaValidated
Annual incidence<1 / 1 000 0000.04LuxembourgValidated
Annual incidence1-9 / 1 000 0000.1MaltaValidated
Annual incidence1-9 / 1 000 0000.18NetherlandsValidated
Annual incidence1-9 / 1 000 0000.2PortugalValidated
Annual incidence1-9 / 1 000 0000.1RomaniaValidated
Annual incidence1-9 / 1 000 0000.1SloveniaValidated

Signs & symptoms

Clinical features (HPO)

62 HPO clinical features (Orphanet curated; top 50 by frequency):

HPO IDTermFrequency
HP:0032252GranulomaVery frequent (80-99%)
HP:0000613PhotophobiaFrequent (30-79%)
HP:0000988Skin rashFrequent (30-79%)
HP:0001324Muscle weaknessFrequent (30-79%)
HP:0001744SplenomegalyFrequent (30-79%)
HP:0001945FeverFrequent (30-79%)
HP:0002014DiarrheaFrequent (30-79%)
HP:0002017Nausea and vomitingFrequent (30-79%)
HP:0002315HeadacheFrequent (30-79%)
HP:0002910Elevated circulating hepatic transaminase concentrationFrequent (30-79%)
HP:0003326MyalgiaFrequent (30-79%)
HP:0003565Elevated erythrocyte sedimentation rateFrequent (30-79%)
HP:0012378FatigueFrequent (30-79%)
HP:0000716DepressionOccasional (5-29%)
HP:0000790HematuriaOccasional (5-29%)
HP:0000952JaundiceOccasional (5-29%)
HP:0000979PurpuraOccasional (5-29%)
HP:0001392Abnormality of the liverOccasional (5-29%)
HP:0001433HepatosplenomegalyOccasional (5-29%)
HP:0001511Intrauterine growth retardationOccasional (5-29%)
HP:0001518Small for gestational ageOccasional (5-29%)
HP:0001562OligohydramniosOccasional (5-29%)
HP:0001622Premature birthOccasional (5-29%)
HP:0001626Abnormality of the cardiovascular systemOccasional (5-29%)
HP:0001824Weight lossOccasional (5-29%)
HP:0001873ThrombocytopeniaOccasional (5-29%)
HP:0001878Hemolytic anemiaOccasional (5-29%)
HP:0001903AnemiaOccasional (5-29%)
HP:0002039AnorexiaOccasional (5-29%)
HP:0002090PneumoniaOccasional (5-29%)
HP:0002240HepatomegalyOccasional (5-29%)
HP:0002360Sleep abnormalityOccasional (5-29%)
HP:0002633VasculitisOccasional (5-29%)
HP:0002829ArthralgiaOccasional (5-29%)
HP:0002922Increased CSF protein concentrationOccasional (5-29%)
HP:0002923Rheumatoid factor positiveOccasional (5-29%)
HP:0003262Smooth muscle antibody positivityOccasional (5-29%)
HP:0003613Antiphospholipid antibody positivityOccasional (5-29%)
HP:0010702Increased circulating antibody levelOccasional (5-29%)
HP:0011227Elevated circulating C-reactive protein concentrationOccasional (5-29%)
HP:0012115HepatitisOccasional (5-29%)
HP:0012735CoughOccasional (5-29%)
HP:0020136Anticardiolipin IgG antibody positivityOccasional (5-29%)
HP:0030166Night sweatsOccasional (5-29%)
HP:0033430Non-infectious meningitisOccasional (5-29%)
HP:0040186Maculopapular exanthemaOccasional (5-29%)
HP:0100584EndocarditisOccasional (5-29%)
HP:0001082CholecystitisVery rare (<1-4%)
HP:0001287MeningitisVery rare (<1-4%)
HP:0001698Pericardial effusionVery rare (<1-4%)

Identifiers

Disease identifiers

FieldValue
Canonical nameQ fever
Mondo IDMONDO:0019186
EFOEFO:0005224
MeSHD011778
Orphanet781
DOIDDOID:11100
ICD-10-CMA78
ICD-112113860626
NCITC34970
SNOMED CT186788009
UMLSC0034362
MedGen48290
GARD0007515
MedDRA10037688, 10037731
NORD1643
Is cancer (heuristic)no

Also known as: Coxiella burnetii caused disease or disorder · Coxiella burnetii disease or disorder · Coxiella burnetii fever · Coxiella burnetii infectious disease · Coxiellosis · infection due to Coxiella burnetii · nine Mile fever · Q fever pneumonia · quadrilateral fever · query fever

Disease family

This is a subtype of primary bacterial infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › primary bacterial infectious disease › Q fever

Related subtypes (36): Buruli ulcer disease, sennetsu fever, salmonellosis, pinta disease, chancroid, gonorrhea, anthrax infection, leprosy, botulism, diphtheria, tetanus, bartonellosis, brucellosis, campylobacteriosis, glanders, granuloma inguinale, legionellosis, leptospirosis, listeriosis, Mycobacterium avium complex disease, ornithosis, rhinoscleroma, staphyloenterotoxemia, syphilis, cholera, ehrlichiosis, melioidosis, tuberculosis, tularemia, plague, shigellosis, Lyme disease, relapsing fever, spirillary rat-bite fever, streptobacillary rat-bite fever, Borrelia miyamotoi disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 10.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified7
PHASE22
PHASE41

Top trials by phase / activity

NCTPhaseStatusTitle
NCT01318356PHASE4COMPLETEDThe Qure Study: Q-fever Fatigue Syndrome - Response to Treatment
NCT00584454PHASE2COMPLETEDSafety Evaluation of a Q-fever Vaccine, NDBR 105
NCT02092142PHASE2WITHDRAWNSafety and Immunogenicity of Q Fever Vaccine
NCT06859619Not specifiedNOT_YET_RECRUITINGSerological Measurement of Montpellier Professionals’ Contacts with Infectious Agents Responsible for Animal-borne Diseases
NCT07358910Not specifiedRECRUITINGRisk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
NCT01095328Not specifiedUNKNOWNA Screening Strategy for Q Fever Among Pregnant Women
NCT01450501Not specifiedUNKNOWNChronic Q-fever in Patients With an Abdominal Aortic Disease (QAAD-study)
NCT02822807Not specifiedCOMPLETEDQ Fever and Auto-immunity
NCT02898402Not specifiedCOMPLETEDStudy on Seroprevalence and Risk Factors of Coxiella Burnetii (Q Fever) in the South of Reunion Island
NCT03334019Not specifiedUNKNOWNPrevalence and Risk Factors for Coxiella Burnetii Seropositivity (Q Fever) Among Adults in Western France

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
DOXYCYCLINE ANHYDROUS43

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 25

This page pulls from 25 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardoidefogardgenccgwasgwas_studyhgncicd10cmicd11meddramedgenmeshmimmondomondochildmondoparentncitnordorphanetsctidumls