Quadriplegia
diseaseOn this page
Also known as bilateral diplegiatetraplegia
Summary
Quadriplegia (MONDO:0001590) is a disease and 127 clinical trials. Top therapeutic interventions include midodrine, ipratropium, and buspirone. A subtype of palsy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 127
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | quadriplegia |
| Mondo ID | MONDO:0001590 |
| EFO | EFO:0009684 |
| MeSH | D011782 |
| DOID | DOID:12835 |
| ICD-10-CM | G82.5 |
| NCIT | C50721 |
| SNOMED CT | 11538006 |
| UMLS | C0034372 |
| MedGen | 19617 |
| Is cancer (heuristic) | no |
Also known as: bilateral diplegia · tetraplegia
Disease family
This is a subtype of palsy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › palsy › quadriplegia
Related subtypes (9): hemiplegia, facial paralysis, ophthalmoplegia, paraplegia, cerebral palsy, progressive bulbar palsy, klumpke’s paralysis, respiratory paralysis, Erb palsy
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 127.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 105 |
| PHASE4 | 6 |
| PHASE2/PHASE3 | 3 |
| PHASE3 | 3 |
| PHASE2 | 3 |
| PHASE1 | 3 |
| PHASE1/PHASE2 | 2 |
| EARLY_PHASE1 | 2 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00507546 | PHASE4 | COMPLETED | Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia |
| NCT01350297 | PHASE4 | COMPLETED | Diaphragmatic Reinnervation of Tetraplegic Patients With Respiratory Insufficiency |
| NCT01579604 | PHASE4 | UNKNOWN | Nerve Transfer Reconstruction in the Tetraplegic Upper Extremity |
| NCT01822535 | PHASE4 | COMPLETED | Body Temperature in Persons With Tetraplegia When Exposed to Cold |
| NCT01896037 | PHASE4 | COMPLETED | Omega-3 Supplementation for Tetraplegics With Poor Cholesterol Levels |
| NCT02379156 | PHASE4 | COMPLETED | Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia |
| NCT00059553 | PHASE2/PHASE3 | UNKNOWN | Retraining Walking After Spinal Cord Injury |
| NCT00632528 | PHASE3 | COMPLETED | MEOPA to Improve Physical Therapy Results After Multilevel Surgery |
| NCT00656149 | PHASE2/PHASE3 | COMPLETED | In-home Telerehabilitation for Quadriplegic Hand Function |
| NCT00753948 | PHASE2/PHASE3 | COMPLETED | Exhaled Levels of Nitric Oxide |
| NCT01569360 | PHASE3 | WITHDRAWN | Study of the Impact of the Use of a Corset on the Respiratory Function of Patients With Spinal Cord Injury |
| NCT03555838 | PHASE3 | UNKNOWN | Combined Robotic Training and tDCS in Chronic SCI |
| NCT02313194 | PHASE1/PHASE2 | ACTIVE_NOT_RECRUITING | Spinal Cord Neuromodulation for Spinal Cord Injury |
| NCT04041063 | PHASE2 | ACTIVE_NOT_RECRUITING | Rehabilitation and Cortical Remodeling After Surgical Intervention for Spinal Cord Injury |
| NCT01046175 | PHASE2 | WITHDRAWN | Effect of Air-stacking on Peak Cough Flow in Patients With Acute Cervical or High Thoracic Spinal Cord Injury |
| NCT01498991 | PHASE1/PHASE2 | TERMINATED | Spinal Cord Injury Leg Rehabilitation |
| NCT05776862 | PHASE2 | COMPLETED | Study Testing Benefits of Ursolic Acid (UA) as a Countermeasure To Myopenia and Insulin Resistance in Chronic Spinal Cord Injury (SCI) |
| NCT01124292 | PHASE1 | COMPLETED | Evaluation of a Tongue Operated Assistive Technology for Individuals With Severe Paralysis |
| NCT01570816 | PHASE1 | UNKNOWN | Improving Ambulatory Community Access After Paralysis |
| NCT02354625 | PHASE1 | COMPLETED | The Safety of ahSC in Chronic SCI With Rehabilitation |
| NCT05163639 | EARLY_PHASE1 | RECRUITING | Spinal Cord Associative Plasticity Study |
| NCT06989905 | EARLY_PHASE1 | RECRUITING | MEP Up-conditioning to Target Corticospinal Plasticity |
| NCT00583804 | Not specified | ACTIVE_NOT_RECRUITING | Implanted Myoelectric Control for Restoration of Hand Function in Spinal Cord Injury |
| NCT00623389 | Not specified | RECRUITING | Evaluation of an Advanced Lower Extremity Neuroprostheses |
| NCT00912041 | Not specified | RECRUITING | BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia |
| NCT01474148 | Not specified | RECRUITING | A Neuroprosthesis for Seated Posture and Balance |
| NCT01894802 | Not specified | RECRUITING | Cortical Recording and Stimulating Array Brain-Machine Interface |
| NCT01958086 | Not specified | RECRUITING | Visuomotor Prosthetic for Paralysis |
| NCT01964261 | Not specified | RECRUITING | Sensory Motor Transformations in Human Cortex |
| NCT03161067 | Not specified | RECRUITING | Investigation on the Bidirectional Cortical Neuroprosthetic System |
| NCT03567213 | Not specified | RECRUITING | Investigation on the Cortical Communication (CortiCom) System |
| NCT03898804 | Not specified | RECRUITING | An Early Feasibility Study of the ReHAB System |
| NCT04023591 | Not specified | ACTIVE_NOT_RECRUITING | Nerve Transfer After Spinal Cord Injury- Multi-center |
| NCT04798378 | Not specified | ACTIVE_NOT_RECRUITING | NuroSleeve Powered Brace & Stimulation System to Restore Arm Function |
| NCT05035823 | Not specified | ACTIVE_NOT_RECRUITING | COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis |
| NCT05321017 | Not specified | RECRUITING | Wrist Extensor MEP Up-conditioning for Individuals With Incomplete Spinal Cord Injury |
| NCT05423600 | Not specified | RECRUITING | Transspinal Stimulation With and Without Blood Flow Restricted Exercise Via Telehealth in Persons With Tetraplegia |
| NCT05553457 | Not specified | RECRUITING | MyHand-SCI: An Active Hand Orthosis for Spinal Cord Injury |
| NCT05638191 | Not specified | RECRUITING | Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury |
| NCT05665998 | Not specified | RECRUITING | Brain Controlled Spinal Cord Stimulation in Participants With Cervical Spinal Cord Injury for Upper Limb Rehabilitation |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| MIDODRINE | 4 | 6 |
| IPRATROPIUM | 4 | 2 |
| BUSPIRONE | 4 | 1 |
| RAMELTEON | 4 | 1 |
| OMEGA-3 FATTY ACIDS | 3 | 1 |
| URSOLIC ACID | 2 | 1 |
| (R)-MIDODRINE | 0 | 2 |
| CHEMBL1908368 | 0 | 1 |
| CHEMBL4576512 | 0 | 1 |
Related Atlas pages
- Drugs: Midodrine, Ipratropium, Buspirone, Ramelteon, OMEGA-3 FATTY ACIDS