Radiation pneumonitis
disease diseaseOn this page
Also known as fibrosis, radiationpneumonia, radiationPneumonias, radiationPneumonitides, radiationpneumonitis, radiationradiation fibrosisradiation pneumoniaradiation Pneumoniasradiation Pneumonitides
Summary
Radiation pneumonitis (MONDO:0043919) is a disease and 35 clinical trials. Top therapeutic interventions include enalapril, captopril, and nicorandil. A subtype of interstitial lung disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 35
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | radiation pneumonitis |
| Mondo ID | MONDO:0043919 |
| MeSH | D017564 |
| ICD-11 | 1914397767 |
| SNOMED CT | 84004001 |
| GARD | 0025873 |
| Is cancer (heuristic) | no |
Also known as: fibrosis, radiation · pneumonia, radiation · Pneumonias, radiation · Pneumonitides, radiation · pneumonitis, radiation · radiation fibrosis · radiation pneumonia · radiation Pneumonias · radiation Pneumonitides · radiation pneumonitis
Disease family
This is a subtype of interstitial lung disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › respiratory system disorder › lower respiratory tract disorder › lung disorder › interstitial lung disease › radiation pneumonitis
Related subtypes (13): pulmonary fibrosis, bronchiolitis obliterans syndrome, pneumoconiosis, pulmonary fibrosis-hepatic hyperplasia-bone marrow hypoplasia syndrome, interstitial lung disease specific to childhood, isolated pulmonary capillaritis, interstitial lung disease specific to adulthood, drug or radiation exposure-related interstitial lung disease, hypersensitivity pneumonitis, secondary pulmonary hemosiderosis, inherited interstitial lung disease, bronchiolocentric pattern of interstitial pneumonia, idiopathic pulmonary fibrosis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated or in trials for this disease
No drug has an approved disease-direct ChEMBL indication for this disease.
3 drugs in clinical trials for this disease (phase 2–3, investigational): efficacy not established — a trial record, not an indication.
| Drug | Highest phase |
|---|---|
| Budesonide | Phase 2 |
| Nicorandil | Phase 2 |
| Pirfenidone | Phase 2 |
Clinical trials & evidence
Clinical trials
Clinical trials: 35.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 21 |
| PHASE2 | 12 |
| EARLY_PHASE1 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT03803787 | PHASE2 | RECRUITING | Prophylactic Inhaled Steroids to Reduce Radiation Pneumonitis Frequency and Severity in Lung Cancer Patients |
| NCT04485286 | PHASE2 | RECRUITING | Evaluation of PET Probe [68Ga]CBP8 in the Detection of Radiation Induced Tissue Injury |
| NCT00041223 | PHASE2 | UNKNOWN | IH636 Grape Seed Extract in Treating Hardening of Breast Tissue in Women Who Have Undergone Radiation Therapy for Early Breast Cancer |
| NCT00077064 | PHASE2 | TERMINATED | Captopril in Treating Patients With Non-Small Cell Lung Cancer or Limited-Stage Small Cell Lung Cancer That Has Been Previously Treated With Radiation Therapy With or Without Chemotherapy |
| NCT00077090 | PHASE2 | UNKNOWN | Hyperbaric Oxygen Therapy Compared With Standard Therapy in Treating Chronic Arm Lymphedema in Patients Who Have Undergone Radiation Therapy for Cancer |
| NCT00589121 | PHASE2 | COMPLETED | Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg |
| NCT01754909 | PHASE2 | COMPLETED | Mitigation of Radiation Pneumonitis and Fibrosis |
| NCT02296281 | PHASE2 | UNKNOWN | Safety and Efficacy Study of Pirfenidone to Treat Grade 2 or Above Radiation-induced Lung Injury |
| NCT02809456 | PHASE2 | UNKNOWN | Mitigation of Radiation Pneumonitis, Fibrosis and Heart Toxicity With Nicorandil in Lung Cancer Patients |
| NCT03796364 | PHASE2 | COMPLETED | Clinical Study of Endostatin in Improving Radiation Pneumonia and Fibrosis |
| NCT04632342 | PHASE2 | UNKNOWN | Phase 2a Clinical Trial to Evaluate the Efficacy and Safety of HL301 on Radiation Pneumonitis in Non-small Cell Lung Cancer Patients |
| NCT06079931 | PHASE2 | UNKNOWN | The Efficacy of Babaodan Capsules in Preventing Radiation Pneumonia |
| NCT06861179 | PHASE1 | COMPLETED | The Formulation of Compound Phellinus Igniarius Decoction on Radiation Pneumonitis |
| NCT05365802 | EARLY_PHASE1 | RECRUITING | FAPI PET for Lung Fibrosis |
| NCT04676828 | Not specified | RECRUITING | Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer |
| NCT04992650 | Not specified | ENROLLING_BY_INVITATION | Ultrasonic Perfusion Imaging in Post-mastectomy Irradiated Patients |
| NCT05189496 | Not specified | RECRUITING | Hyperbaric Oxygen in the Prevention of Radiation Pneumonitis |
| NCT05448703 | Not specified | RECRUITING | A Study on Predictive Models and Clinical Outcome of Radiation Pneumonitis |
| NCT06069115 | Not specified | RECRUITING | Radiotherapy Exposed Lung Injury: Effect on Functioning - Cohort |
| NCT06557343 | Not specified | RECRUITING | Single-Cell Sequencing Analysis of Radiation Pneumonitis Signals In Patients Treated For Cancer With Radiotherapy |
| NCT06570317 | Not specified | RECRUITING | Nintedanib for the Prevention of Radiation Pneumonia in Unresectable NSCLC |
| NCT06708754 | Not specified | RECRUITING | Impact of Photobiomodulation (PBM) on Biomarkers of Radiation Lymphedema and Fibrosis in Head and Neck Cancer Patients |
| NCT07188116 | Not specified | NOT_YET_RECRUITING | Correlation Between COVID-19 and Radiation Pneumonitis in Breast Cancer |
| NCT07312682 | Not specified | ACTIVE_NOT_RECRUITING | Application of 4DCT-Based Pulmonary Ventilation Imaging in Lung Cancer Radiotherapy |
| NCT07339644 | Not specified | RECRUITING | Functional Lung Avoidance Radiotherapy Guided by 4DCT Pulmonary Ventilation Function Imaging: A Prospective Single-arm Clinical Study |
| NCT00020631 | Not specified | COMPLETED | Pirfenidone in Treating Patients With Fibrosis Caused by Radiation Therapy for Cancer |
| NCT00155909 | Not specified | UNKNOWN | Risk Factors of Radiation Pneumonitis |
| NCT00880386 | Not specified | WITHDRAWN | Losartan in Treating Pulmonary Fibrosis in Patients With Stage I, II, or III Non-Small Cell Lung Cancer |
| NCT01745484 | Not specified | COMPLETED | Role of SPECT in Radiotherapy of Lung Cancer and Toxicity Evaluation |
| NCT02490319 | Not specified | UNKNOWN | Study on the Biological Prediction Models of Radiation Pneumonitis |
| NCT02735746 | Not specified | COMPLETED | Novel Lung Imaging in Adults Undergoing Radiation Therapy to Assess for Radiation Pneumonitis |
| NCT03462524 | Not specified | COMPLETED | Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary Physiology |
| NCT03496909 | Not specified | WITHDRAWN | PhysioTouch for Treatment of Radiation Fibrosis |
| NCT04863027 | Not specified | COMPLETED | Use of Dual Energy Computed Tomography in Thoracic Radiotherapy Planning. |
| NCT05890196 | Not specified | COMPLETED | Autologous Fat Grafting in Radiated Soft Tissue Reconstruction |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ENALAPRIL | 4 | 3 |
| CAPTOPRIL | 4 | 1 |
| NICORANDIL | 4 | 1 |
| OXYGEN | 4 | 1 |
| PIRFENIDONE | 4 | 1 |
| ENDOSTATIN, N-TERMINAL-MGGSHHHHH | 3 | 1 |