Radiation proctitis
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Summary
Radiation proctitis (MONDO:0019084) is a disease and 19 clinical trials. Top therapeutic interventions include hyaluronic acid, sucralfate, and maltodextrin. A subtype of proctitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: 1-5 / 10 000 (Europe) [Orphanet-validated]
- Phenotypes (HPO): 19
- Clinical trials: 19
Clinical features
Epidemiology
Prevalence records
1 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Point prevalence | 1-5 / 10 000 | 35 | Europe | Validated |
Signs & symptoms
Clinical features (HPO)
19 HPO clinical features (Orphanet curated; top 19 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0002034 | Abnormality of the rectum | Very frequent (80-99%) |
| HP:0002583 | Colitis | Very frequent (80-99%) |
| HP:0002597 | Abnormality of the vasculature | Very frequent (80-99%) |
| HP:0003549 | Abnormality of connective tissue | Very frequent (80-99%) |
| HP:0004296 | Abnormality of gastrointestinal vasculature | Very frequent (80-99%) |
| HP:0005224 | Rectal abscess | Very frequent (80-99%) |
| HP:0025015 | Abnormal vascular morphology | Very frequent (80-99%) |
| HP:0100590 | Rectal fistula | Very frequent (80-99%) |
| HP:0002019 | Constipation | Frequent (30-79%) |
| HP:0002027 | Abdominal pain | Frequent (30-79%) |
| HP:0100279 | Ulcerative colitis | Frequent (30-79%) |
| HP:0500005 | Anal pain | Frequent (30-79%) |
| HP:0005214 | Intestinal obstruction | Occasional (5-29%) |
| HP:0012089 | Arteritis | Occasional (5-29%) |
| HP:0012702 | Tenesmus | Occasional (5-29%) |
| HP:0100806 | Sepsis | Occasional (5-29%) |
| HP:0002014 | Diarrhea | Very rare (<1-4%) |
| HP:0002573 | Hematochezia | Very rare (<1-4%) |
| HP:0002607 | Bowel incontinence | Very rare (<1-4%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | radiation proctitis |
| Mondo ID | MONDO:0019084 |
| Orphanet | 70475 |
| ICD-10-CM | K62.7 |
| ICD-11 | 177305885 |
| SNOMED CT | 235760009 |
| UMLS | C0400827 |
| MedGen | 586421 |
| GARD | 0018900 |
| MedDRA | 10037766 |
| NORD | 1615 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of proctitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › large intestine disorder › rectal disorder › anus disorder › proctitis › radiation proctitis
Related subtypes (1): proctocolitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 19.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 6 |
| PHASE2 | 4 |
| PHASE4 | 2 |
| PHASE3 | 2 |
| PHASE2/PHASE3 | 2 |
| PHASE1/PHASE2 | 2 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00756197 | PHASE4 | WITHDRAWN | CryoSpray Ablation(TM)to Determine Safety and Feasibility in Radiation Induced Proctitis |
| NCT01613534 | PHASE4 | COMPLETED | Combined Therapy in Radiation Proctopathy |
| NCT06837597 | PHASE3 | NOT_YET_RECRUITING | Jianzhong Qushi in Chronic RRI |
| NCT01414517 | PHASE3 | UNKNOWN | Study to Prevent Radiation Induced Damage to Bowel Using a Prebiotic Enhanced Diet. |
| NCT01901042 | PHASE2/PHASE3 | COMPLETED | Efficacy of Symbiotic in the Reduction of Acute Radiation Proctitis Symptoms |
| NCT05406882 | PHASE2/PHASE3 | UNKNOWN | The Effects of Probiotics Combined With Glutamine in the Prevention and Treatment of Radiation Proctitis |
| NCT06438809 | PHASE1/PHASE2 | RECRUITING | Umbilical-Cord-Derived Mesenchymal Stem Cells Injection for Chronic Radiation Proctitis |
| NCT06776016 | PHASE2 | RECRUITING | Dietary Supplements to Treat Radiation-Induced Rectal Injury |
| NCT07248020 | PHASE2 | NOT_YET_RECRUITING | A Phase II Single-Arm Study of High-Bioavailability Curcumin as Neoadjuvant Chemoradiotherapy in Mid-to-Low Rectal Cancer: Integrated Clinical and Translational Analysis of Tumor Tissue |
| NCT00828230 | PHASE2 | TERMINATED | Budesonide Foam Versus Placebo for Prevention of Acute Radiation Proctitis |
| NCT04680195 | PHASE2 | UNKNOWN | Thalidomide in the Treatment of Chronic Radiation Proctitis With Intractable Bleeding |
| NCT06469216 | PHASE1/PHASE2 | COMPLETED | Efficacy of Hyaluronic Acid in Prevention of Acute Radiation Proctitis |
| NCT06925607 | PHASE1 | NOT_YET_RECRUITING | Evaluate the Distribution and Dynamic Behavior of Nuclide Labeled TH-SC01 Cells in Vivo in Patients With Radiation Proctitis |
| NCT06087718 | Not specified | ACTIVE_NOT_RECRUITING | Feasibility of the Maastro Applicator in Rectal Cancer |
| NCT07259681 | Not specified | NOT_YET_RECRUITING | Gut Microbiome in Gynecological Cancer Patients With Pelvic Toxicity: Controls Versus Ozone Treatment. (MicrOzoGineTox) |
| NCT07378631 | Not specified | RECRUITING | Association Between Clinical Subtypes and Prognosis in Radiation Rectal Injury |
| NCT07611864 | Not specified | RECRUITING | Soft Tissue Radiation Injury; Patient Reported Evaluation in a Single Centre Cohort Study (STRIPE) |
| NCT03397901 | Not specified | UNKNOWN | Transverse Colostomy for Refractory Hemorrhagic Chronic Radiation Proctitis: a Prospective Cohort Study |
| NCT05489107 | Not specified | UNKNOWN | New Local Treatment of Radiation-induced Proctitis |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| HYALURONIC ACID | 4 | 1 |
| SUCRALFATE | 4 | 1 |
| MALTODEXTRIN | 3 | 2 |
| CURCUMIN | 3 | 1 |
| BUTYRIC ACID | 2 | 1 |
| CHEMBL2367706 | 0 | 1 |
Related Atlas pages
- Drugs: Hyaluronic Acid, Sucralfate, Maltodextrin, Curcumin