Radiculopathy
diseaseOn this page
Also known as nerve root disorder
Summary
Radiculopathy (MONDO:0002959) is a disease and 81 clinical trials. Top therapeutic interventions include sumatriptan, tizanidine, and baclofen. A subtype of peripheral nervous system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 81
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | radiculopathy |
| Mondo ID | MONDO:0002959 |
| MeSH | D011843 |
| DOID | DOID:4306 |
| ICD-10-CM | M54.1 |
| ICD-11 | 1802542189 |
| SNOMED CT | 72274001 |
| UMLS | C0700594 |
| MedGen | 147133 |
| Is cancer (heuristic) | no |
Also known as: nerve root disorder
Disease family
This is a subtype of peripheral nervous system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › peripheral nervous system disorder › radiculopathy
Related subtypes (17): autoimmune disorder of peripheral nervous system, autonomic nervous system disorder, peripheral nervous system neoplasm, vestibulocochlear nerve disorder, hypoglossal nerve disorder, facial nerve disorder, neuroma, accessory nerve disorder, glossopharyngeal nerve disorder, olfactory nerve disorder, trigeminal nerve disorder, third cranial nerve disorder, peripheral neuropathy, cauda equina syndrome, peroneal nerve paralysis, trochlear nerve disorder, abducens nerve disorder
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
0 approved, 4 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Bupivacaine | Phase 3 (in late-stage trials) |
| Pregabalin | Phase 3 (in late-stage trials) |
| Triamcinolone | Phase 3 (in late-stage trials) |
| Triamcinolone Acetonide | Phase 3 (in late-stage trials) |
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Dexamethasone, Etanercept, Lenalidomide, Methylprednisolone, Sodium Chloride, Vixotrigine.
Clinical trials & evidence
Clinical trials
Clinical trials: 81.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 61 |
| PHASE3 | 8 |
| PHASE2 | 4 |
| PHASE2/PHASE3 | 3 |
| PHASE1 | 2 |
| PHASE4 | 1 |
| PHASE1/PHASE2 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02265848 | PHASE4 | COMPLETED | High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System |
| NCT00120120 | PHASE2/PHASE3 | COMPLETED | Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Painful Lumbar Radiculopathy |
| NCT00159705 | PHASE3 | COMPLETED | Trial of Efficacy and Safety of Pregabalin in Subjects With Neuropathic Pain Associated With Lumbo-Sacral Radiculopathy |
| NCT00578812 | PHASE3 | COMPLETED | PCM Cervical Disc System |
| NCT00942227 | PHASE3 | COMPLETED | The Value of Traction in Treatment of Lumbar Radiculopathy |
| NCT00979108 | PHASE3 | COMPLETED | The Value of Traction in the Treatment of Cervical Radiculopathy |
| NCT01073995 | PHASE3 | COMPLETED | The Effectiveness of Selective Nerve Root Injections in Preventing the Need for Surgery |
| NCT01905930 | PHASE3 | COMPLETED | Post-Approval Clinical Trial of the PCM® Cervical Disc |
| NCT02618278 | PHASE3 | COMPLETED | Physiotherapy for Sciatica; Is Earlier Better? |
| NCT03327272 | PHASE3 | WITHDRAWN | Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion |
| NCT04559295 | PHASE2/PHASE3 | UNKNOWN | Bone Marrow Concentrate (BMC) Injection in Intervertebral Discs |
| NCT04621799 | PHASE2/PHASE3 | UNKNOWN | Fibrin for Chronic Multi-level Discogenic Low Back Pain |
| NCT00009672 | PHASE2 | COMPLETED | Pain Treatment for Sciatica |
| NCT00107055 | PHASE2 | UNKNOWN | Study of REN-1654 in Patients With Sciatica Pain |
| NCT01088256 | PHASE2 | TERMINATED | Efficacy of Etoricoxib on Peripheral Hyperalgesia |
| NCT01873404 | PHASE2 | COMPLETED | BG00010 (Neublastin) Phase 2 Multiple Dose Adaptive Design in Participants With Painful Lumbar Radiculopathy |
| NCT04760613 | PHASE1/PHASE2 | COMPLETED | CBD for Chronic Radicular Pain on Chronic Opioid Therapy (COT) |
| NCT02644421 | PHASE1 | COMPLETED | Clinical Trial to Evaluate the Safety and Analgesic Efficacy of VVZ-149 in Lumbar Radiculopathy (Sciatica) |
| NCT03556137 | PHASE1 | UNKNOWN | PET/MRI in the Diagnosis of Chronic Pain |
| NCT05261581 | EARLY_PHASE1 | WITHDRAWN | Evaluation of Erector Spina Plane Block(ESPB)’s Effectiveness on Patients With Lumbar Radiculopathy |
| NCT04273828 | Not specified | RECRUITING | Impact of Muscle Degeneration in Chronic Low Back Pain |
| NCT04909138 | Not specified | RECRUITING | Intermittent Dosing of Dorsal Root Ganglion Stimulation as an Alternate Paradigm to Continuous Low-Frequency Therapy |
| NCT05035693 | Not specified | RECRUITING | Post Market Clinical Follow up Study With the Cervical Disc Prothesis MOVE®-C |
| NCT05696470 | Not specified | ACTIVE_NOT_RECRUITING | Fusion Rates of 3D Printed Porous Titanium Cages in Three and Four Level ACDFs |
| NCT05745129 | Not specified | ENROLLING_BY_INVITATION | Applying Artificial Intelligence in Developing Personalized and Sustainable Healthcare for Spinal Disorders |
| NCT05817747 | Not specified | RECRUITING | Strategic Use of Big Data in Spine Surgery - Testing Digital Prediction of Outcome in Clinical Praxis |
| NCT05952167 | Not specified | RECRUITING | Evaluation of the Impact of Tractions vs. Placebo Tractions in Patients With Cervical Radiculopathy |
| NCT06891690 | Not specified | RECRUITING | Use of TDCS Stimulation in Neurological and Gynaecological Conditions |
| NCT06956664 | Not specified | RECRUITING | Exercise Therapy After Caudal Epidural Steroid Injection |
| NCT07080307 | Not specified | NOT_YET_RECRUITING | Artificial Intelligence (AI)-Based Prediction of Treatment Response in Sciatica Patients Receiving Transforaminal Epidural Steroid Injection |
| NCT07366983 | Not specified | NOT_YET_RECRUITING | Effect of Cervical Traction With Neural Mobilization on Nerve Root Functions in Cervical Radiculopathy Patients |
| NCT07543692 | Not specified | NOT_YET_RECRUITING | Safety and Effectiveness of Ultrasound-guided Pharmacopuncture for Spinal Diseases |
| NCT07558993 | Not specified | NOT_YET_RECRUITING | Mirror Image Spine Correction Exercises Versus Conservative Physiotherapy for Lumbar Radiculopathy |
| NCT00437190 | Not specified | COMPLETED | Pivotal IDE Study of the BRYAN(R) Cervical Disc Prosthesis in the Treatment of DDD Versus ACDF |
| NCT00440856 | Not specified | COMPLETED | Presentation of Lumbar Disc and Reduction of Symptoms |
| NCT00546949 | Not specified | TERMINATED | Treatment of Lumbar Spinal Stenosis; Comparison of Two Different Surgical Methods; Mini-invasive Decompression to X-stop |
| NCT00585923 | Not specified | TERMINATED | Slotted Hole Versus Fixed Hole C-Tek |
| NCT00637156 | Not specified | COMPLETED | Study of the Safety and Effectiveness of the Artificial Cervical Disc - Low Profile Device at Two Adjacent Levels |
| NCT00894972 | Not specified | COMPLETED | Rehabilitation Following Lumbar Disc Surgery |
| NCT00934284 | Not specified | COMPLETED | Effectiveness Study of Physical Therapy as an Adjunct to a Lumbar Therapeutic Selective Nerve Root Block |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| SUMATRIPTAN | 4 | 3 |
| TIZANIDINE | 4 | 2 |
| BACLOFEN | 4 | 1 |
| BUPIVACAINE | 4 | 1 |
| CYCLOBENZAPRINE | 4 | 1 |
| ESFLURBIPROFEN | 4 | 1 |
| ETORICOXIB | 4 | 1 |
| FLURBIPROFEN | 4 | 1 |
| LENALIDOMIDE | 4 | 1 |
| MELOXICAM | 4 | 1 |
| MENTHOL | 4 | 1 |
| NORTRIPTYLINE | 4 | 1 |
| PRILOCAINE | 4 | 1 |
| TRIAMCINOLONE ACETONIDE | 4 | 1 |
| FIBRIN | 3 | 1 |
| LEVOMENTHOL | 3 | 1 |
| ZUCAPSAICIN | 3 | 1 |
| ARTEMIN | 2 | 1 |