Radiodermatitis
diseaseOn this page
Also known as Dermatitides, radiation recallDermatitides, radiation-induceddermatitis radiationdermatitis, radiation induceddermatitis, radiation recalldermatitis, radiation-inducedradiation dermatitisradiation induced dermatitisradiation recall Dermatitidesradiation recall dermatitisradiation recall reactionradiation recall reactionsradiation-induced Dermatitidesradiation-induced dermatitisRadiodermatitidesreaction, radiation recallreactions, radiation recallrecall reaction, radiationrecall reactions, radiation
Summary
Radiodermatitis (MONDO:0043771) is a disease and 107 clinical trials. Top therapeutic interventions include calcipotriene, cianidanol, and dimethyl sulfoxide. A subtype of dermatitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 107
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | radiodermatitis |
| Mondo ID | MONDO:0043771 |
| MeSH | D011855 |
| ICD-10-CM | L58 |
| NCIT | C3349 |
| SNOMED CT | 49084001 |
| GARD | 0025867 |
| Is cancer (heuristic) | no |
Also known as: Dermatitides, radiation recall · Dermatitides, radiation-induced · dermatitis radiation · dermatitis, radiation induced · dermatitis, radiation recall · dermatitis, radiation-induced · radiation dermatitis · radiation induced dermatitis · radiation recall Dermatitides · radiation recall dermatitis · radiation recall reaction · radiation recall reactions · radiation-induced Dermatitides · radiation-induced dermatitis · Radiodermatitides · radiodermatitis · reaction, radiation recall · reactions, radiation recall · recall reaction, radiation · recall reactions, radiation
Disease family
This is a subtype of dermatitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › integumentary system disorder › skin disorder › dermatitis › radiodermatitis
Related subtypes (32): spongiotic dermatitis, atopic eczema, psoriasis, contact dermatitis, urticaria, acneiform dermatitis, acrodermatitis, folliculitis, granuloma annulare, granulomatous dermatitis, lichen planus, neurodermatitis, neurotic excoriation, parapsoriasis, pityriasis rosea, seborrheic dermatitis, acanthosis nigricans, dermatosis papulosa nigra, lichen sclerosus et atrophicus, vitiligo, acne, porphyria cutanea tarda, dermatomyositis, acute generalized exanthematous pustulosis, hydroa vacciniforme, autoimmune bullous skin disease, cutaneous vasculitis, skin infection, intertrigo, lipodermatosclerosis, exfoliative dermatitis, food dermatitis
Subtypes (1): photosensitivity disease
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
0 approved, 2 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Aloe | Phase 3 (in late-stage trials) |
| Urea | Phase 3 (in late-stage trials) |
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Calcipotriene, Chamomile, Curcumin, Mometasone Furoate, Mupirocin, Polyethylene Glycol.
Clinical trials & evidence
Clinical trials
Clinical trials: 107.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 65 |
| PHASE2 | 13 |
| PHASE3 | 11 |
| PHASE1/PHASE2 | 6 |
| PHASE1 | 6 |
| PHASE2/PHASE3 | 4 |
| PHASE4 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02495064 | PHASE4 | UNKNOWN | Mometasone Furoate Cream Reduces Acute Radiation Dermatitis in Head and Neck Squamous Cell Carcinomas’ Patients |
| NCT06915857 | PHASE3 | RECRUITING | Topical Betamethasone Versus Moisturizer in Preventing Radiation Dermatitis in Large-Breasted Patients Treated in the Prone Position |
| NCT07066280 | PHASE3 | RECRUITING | Modulating the Skin Microbiome to Prevent Radiation Dermatitis in Breast Cancer |
| NCT07149506 | PHASE3 | ENROLLING_BY_INVITATION | Oral or Topical Catechins for Radiation Dermatitis |
| NCT07353671 | PHASE2/PHASE3 | RECRUITING | Topical Periplaneta Americana-Derived Meilian Fuxin Liquid for Radiation Dermatitis |
| NCT00481884 | PHASE3 | COMPLETED | Comparing RadiaPlexRx Hydrogel and Standard-of-Care for Radiation Dermatitis in Breast Cancer Patients |
| NCT00876642 | PHASE3 | COMPLETED | Trial Comparing Best Supportive Care to Aloe Vera Gel |
| NCT01246973 | PHASE2/PHASE3 | COMPLETED | Oral Curcumin for Radiation Dermatitis |
| NCT02247830 | PHASE3 | COMPLETED | Management Radiodermatitis in Patients With Breast or Head and Neck Cancer |
| NCT02251392 | PHASE3 | UNKNOWN | Evaluation of Therapeutic Efficacy in Use of Chamomilla Gel, Chamomilla Infuse and Urea in Radiodermatitis |
| NCT02369835 | PHASE3 | COMPLETED | Modified Dakin’s Solution in Reducing Radiation-Induced Dermatitis in Patients With Head and Neck Cancer Undergoing Radiation Therapy |
| NCT02839473 | PHASE3 | COMPLETED | Hydrosorb® Versus Control in the Management of Radio-induced Skin Toxicity: Multicentre Controlled Phase III Randomized Trial |
| NCT03883828 | PHASE2/PHASE3 | COMPLETED | Bacterial Decolonization to Prevent Radiation Dermatitis |
| NCT04059809 | PHASE2/PHASE3 | COMPLETED | Photobiomodulation for Breast Cancer Radiodermatitis |
| NCT04239560 | PHASE3 | COMPLETED | Preventive Effect of Boron-based Gel on Radiation Dermatitis |
| NCT04300829 | PHASE3 | UNKNOWN | Cicaderma Efficacy vs Standard Care of Sites in Preventing Radiodermatitis in Non-metastatic Breast Cancer Patients |
| NCT07029178 | PHASE2 | RECRUITING | Taurine’s Therapeutic Effect on Acute Radiation-induced Oral Mucositis and Dermatitis |
| NCT00445250 | PHASE2 | UNKNOWN | The Role of Calcipotriol as Radioprotector of Skin |
| NCT01513278 | PHASE1/PHASE2 | COMPLETED | Study of APN201 (Liposomal Recombinant Human Cu/Zn-Superoxide Dismutase) for the Prevention of Radiation-induced Dermatitis in Women With Breast Cancer |
| NCT01544504 | PHASE1/PHASE2 | WITHDRAWN | Exploratory Study of Topical Norepinephrine in Breast Cancer Patients Receiving Radiotherapy |
| NCT02051907 | PHASE2 | UNKNOWN | Clinical Study to Evaluate Safety and Efficacy of KAM1403 Gel to Treat Radiation Dermatitis |
| NCT02249884 | PHASE2 | COMPLETED | Dose-Response Curve: Interventions to Prevent and Treat Radiodermatitis |
| NCT02289365 | PHASE2 | UNKNOWN | Orally Administrated JBM-TC4 Prevents Acute Radiodermatitis in Breast Cancer Patients |
| NCT02534129 | PHASE1/PHASE2 | TERMINATED | Topical Use of Difinsa53™ to Prevent Radiation Dermatitis |
| NCT02556632 | PHASE2 | COMPLETED | Prophylactic Topical Agents in Reducing Radiation-Induced Dermatitis in Patients With Non-inflammatory Breast Cancer |
| NCT02729324 | PHASE2 | UNKNOWN | Comparison of Efficacy and Safety Between Medical Radiation Protectants (FORRAD®) and Trolamine (Biafine) for the Management of Radiation Dermatitis in Patients With Nasopharyngeal Carcinoma Receiving IMRT |
| NCT03494205 | PHASE2 | COMPLETED | Urtica Comp. Gel for Prevention and Therapy of Radiation Dermatitis |
| NCT03716583 | PHASE2 | COMPLETED | Melatonin Cream Against Acute Radiation Dermatitis in Patients With Early Breast Cancer |
| NCT04149522 | PHASE2 | TERMINATED | Evaluation of Mepitel Film® in Preventing Epidermitis in Patients Receiving Radiation Therapy for Breast Cancer |
| NCT04261387 | PHASE1/PHASE2 | COMPLETED | LUT014 for the Treatment of Radiation Induced Dermatitis in Breast Cancer Patients |
| NCT04617730 | PHASE1/PHASE2 | UNKNOWN | Efficacy of the Mepitel® Film on the Prevention of Radiodermatitis in the Inguinal Fold. |
| NCT04888234 | PHASE2 | UNKNOWN | Evaluation the Effectiveness of Ru-Yi-Jin-Huang Powder for the Radiation-induced Dermatitis. |
| NCT05269160 | PHASE1/PHASE2 | TERMINATED | Topical Dermaprazole for Radiation Dermatitis in Breast Cancer Patients (TOPAZ) |
| NCT05505214 | PHASE2 | WITHDRAWN | Topical Steroids & Bacterial Decolonization for Radiation Dermatitis |
| NCT05693597 | PHASE2 | COMPLETED | Evaluation of the Effect of Nigella Sativa for the Prophylaxis to Radiation Induced Dermatitis in Breast Cancer Patients |
| NCT01263366 | PHASE1 | TERMINATED | Exploratory Study of Norepinephrine to Prevent Radiodermatitis in Breast Cancer Patients |
| NCT01367990 | PHASE1 | TERMINATED | Exploratory Study of Norepinephrine to Prevent Alopecia in Head and Neck Cancer Patients Treated With Radiotherapy |
| NCT01714973 | PHASE1 | COMPLETED | Study of ST266 Versus Saline in Treating Skin Irritation From Radiation |
| NCT04238728 | PHASE1 | COMPLETED | Silverlon to Reduce Radiation Dermatitis |
| NCT05114226 | PHASE1 | UNKNOWN | A Study for Assessing the Efficacy and Safety of Tetrahydrobiopterin in Radiation-Induced Skin Injury |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CALCIPOTRIENE | 4 | 1 |
| CIANIDANOL | 4 | 1 |
| DIMETHYL SULFOXIDE | 4 | 1 |
| MOMETASONE FUROATE | 4 | 1 |
| MUPIROCIN | 4 | 1 |
| NOREPINEPHRINE | 4 | 1 |
| PETROLATUM, WHITE | 4 | 1 |
| SAPROPTERIN | 4 | 1 |
| SODIUM HYPOCHLORITE | 4 | 1 |
| SULFADIAZINE, SILVER | 4 | 1 |
| UREA | 4 | 1 |
| ALOE | 3 | 1 |
| CURCUMIN | 3 | 1 |
| TAURINE | 3 | 1 |
| TROLAMINE | 2 | 2 |
| (+)-EPICATECHIN | 2 | 1 |
| (-)-EPICATECHIN | 2 | 1 |
| CHEMBL432 | 0 | 3 |
| CHEMBL4793658 | 0 | 1 |
| CHEMBL1814389 | 0 | 1 |
| CHEMBL80941 | 0 | 1 |
| CHEMBL4563773 | 0 | 1 |
| CHEMBL4796961 | 0 | 1 |
| CHEMBL4063304 | 0 | 1 |
| CATECHIN | 0 | 1 |