Rapidly involuting congenital hemangioma

Summary

Rapidly involuting congenital hemangioma (MONDO:0015404) is a disease. A subtype of congenital hemangioma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 14

Clinical features

Signs & symptoms

Clinical features (HPO)

14 HPO clinical features (Orphanet curated; top 14 by frequency):

HPO ID	Term	Frequency
HP:0001028	Hemangioma	Obligate (100%)
HP:0007466	Midfrontal capillary hemangioma	Frequent (30-79%)
HP:0007618	Subcutaneous calcification	Frequent (30-79%)
HP:0031449	Perineal hemangioma	Frequent (30-79%)
HP:0100585	Telangiectasia of the skin	Frequent (30-79%)
HP:0001015	Prominent superficial veins	Occasional (5-29%)
HP:0001635	Congestive heart failure	Occasional (5-29%)
HP:0001873	Thrombocytopenia	Occasional (5-29%)
HP:0100784	Peripheral arteriovenous fistula	Occasional (5-29%)
HP:0410266	Visceral hemangioma	Occasional (5-29%)
HP:0012329	Tufted angioma	Excluded (0%)
HP:0010885	Avascular necrosis	Very rare (<1-4%)
HP:0031207	Hepatic hemangioma	Very rare (<1-4%)
HP:0100578	Lipoatrophy	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	rapidly involuting congenital hemangioma
Mondo ID	MONDO:0015404
Orphanet	141184
DOID	DOID:0080895
NCIT	C172207
SNOMED CT	703294004
UMLS	C1275421
MedGen	698687
GARD	0019958
Is cancer (heuristic)	no

Also known as: RICH · rich

Disease family

This is a subtype of congenital hemangioma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › benign neoplasm › cardiovascular organ benign neoplasm › benign blood vessel neoplasm › hemangioma › congenital hemangioma › rapidly involuting congenital hemangioma

Related subtypes (2): non-involuting congenital hemangioma, partially involuting congenital hemangioma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.