Rectal disorder

Summary

Rectal disorder (MONDO:0001593) is a disease (an umbrella term covering 6 Mondo subtypes) and 2 clinical trials. A subtype of large intestine disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Umbrella term: 6 Mondo subtypes
• Clinical trials: 2

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	rectal disorder
Mondo ID	MONDO:0001593
EFO	EFO:0009685
MeSH	D012002
DOID	DOID:1285
SNOMED CT	5964004
UMLS	C0034882
MedGen	19701
Anatomy (UBERON)	UBERON:0001052
Is cancer (heuristic)	no

Also known as: disease of rectum · disease or disorder of rectum · disorder of rectum · rectal disorder · rectum disease · rectum disease or disorder

Disease family

An umbrella term covering 6 Mondo subtypes.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › large intestine disorder › rectal disorder

Related subtypes (10): anal canal cancer, colonic disorder, colorectal neoplasm, Crohn’s colitis, epithelial tumor of anal canal, shigellosis, polyp of large intestine, benign neoplasm of large intestine, colorectal Kaposi sarcoma, disorder of appendix

Subtypes (6): anal fistula, ulcer of anus and rectum, rectal neoplasm, anus disorder, rectal prolapse, polyp of rectum

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

2 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Camphor	Approved (phase 4)
Lidocaine	Approved (phase 4)
Dexmedetomidine	Phase 3 (in late-stage trials)

Clinical trials & evidence

Clinical trials

Clinical trials: 2.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05368168	Not specified	RECRUITING	Impact of Early Postoperative Treatment With Posterior Tibial Nerve Stimulation on the Incidence and Duration of Low Anterior Rectal Resection Syndrome
NCT05231473	Not specified	COMPLETED	Impact Of The Nurse Enhanced Recovery After Surgery Coordinator On The Compliance In Colorectal Surgery (nursERAS-BCN)