Rectal prolapse
diseaseOn this page
Also known as rectal prolapse (disease)
Summary
Rectal prolapse (MONDO:0004754) is a disease and 46 clinical trials. Top therapeutic interventions include sodium chloride. A subtype of rectal disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- ClinVar variants: 1
- Clinical trials: 46
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | rectal prolapse |
| Mondo ID | MONDO:0004754 |
| MeSH | D012005 |
| DOID | DOID:9307 |
| ICD-10-CM | K62.3 |
| ICD-11 | 231914102 |
| NCIT | C34973 |
| UMLS | C0034888 |
| MedGen | 11151 |
| Is cancer (heuristic) | no |
Also known as: rectal prolapse · rectal prolapse (disease)
Data availability: 1 ClinVar variant · 1 HPO phenotype.
Disease family
This is a subtype of rectal disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › large intestine disorder › rectal disorder › rectal prolapse
Related subtypes (5): anal fistula, ulcer of anus and rectum, rectal neoplasm, anus disorder, polyp of rectum
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
ClinVar germline variants
1 retrieved; paginated sample, class counts are floors:
1 pathogenic/likely pathogenic
| ClinVar | Variant (HGVS) | Gene | Classification | Review |
|---|---|---|---|---|
| 373443 | NM_001292034.3(TAB2):c.1039C>T (p.Arg347Ter) | LOC126859827 | Pathogenic/Likely pathogenic | criteria provided, multiple submitters, no conflicts |
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 46.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 41 |
| PHASE4 | 3 |
| PHASE3 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00810745 | PHASE4 | COMPLETED | What Benefit With a New Stapler Device in the Surgical Treatment of Obstructed Defecation? |
| NCT01056913 | PHASE4 | COMPLETED | NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery |
| NCT01346436 | PHASE4 | UNKNOWN | Value of Robotic Rectopexy for the Treatment of Complex Pelvic Floor Dysfunction |
| NCT01022034 | PHASE3 | COMPLETED | Pexy Versus Non-pexy for Full Thickness Rectal Prolapse |
| NCT06174584 | EARLY_PHASE1 | COMPLETED | Comparison of Cow Milk and 15% Hypertonic Saline in the Treatment of Rectal Prolapse in Children |
| NCT03052985 | Not specified | ACTIVE_NOT_RECRUITING | Materiovigilance After Urinary Incontinence or Prolapse Surgery |
| NCT04013152 | Not specified | ACTIVE_NOT_RECRUITING | Clinical Database of Colorectal Robotic Surgery |
| NCT04169152 | Not specified | RECRUITING | CAES for Internal Hemorrhoids and Rectal Prolapse |
| NCT05321134 | Not specified | RECRUITING | Evaluation of SINGLE PORT (SP) Robotic Technology in Colorectal Surgery |
| NCT05569980 | Not specified | ENROLLING_BY_INVITATION | The Nordic Rectal Prolapse Study |
| NCT05918367 | Not specified | RECRUITING | Multicenter Ventral Mesh Rectopexy Registry Collaborative |
| NCT06245577 | Not specified | ACTIVE_NOT_RECRUITING | Biological Mesh Versus Synthetic Mesh in Interdisciplinary RRP With SCP |
| NCT06430931 | Not specified | RECRUITING | Biological OviTex Versus Synthetic Graft in Robotic Prolapse Surgery |
| NCT06455501 | Not specified | NOT_YET_RECRUITING | FOAM: Functional Outcome After Ventral Mesh Rectopexy |
| NCT06926374 | Not specified | RECRUITING | Prospective Evaluation of Cornerstone Robotics Sentire Surgical System in Major Gastrointestinal and Urologic Surgery |
| NCT00946205 | Not specified | COMPLETED | Laparoscopic Rectopexy for Rectal Prolapse |
| NCT01301417 | Not specified | COMPLETED | Data Collection of Patients Treated With the ColonRing™ for the Creation of Circular Compression Anastomosis |
| NCT01595412 | Not specified | TERMINATED | An International Double Cohort Study to Compare Laparoscopic Ventral Rectopexy With Laparoscopic Resection Rectopexy |
| NCT01656369 | Not specified | COMPLETED | Comparative Study Between Delorme Operation With or Without Postanal Repair in Treatment of Complete Rectal Prolapse |
| NCT01880918 | Not specified | UNKNOWN | A RETROspective Data Collection of comPRESSion Anastomosis Using the ColonRing |
| NCT01899209 | Not specified | UNKNOWN | Surgical Treatment of Obstructed Defecation Syndrome |
| NCT01980043 | Not specified | COMPLETED | Endoluminal and Needlescopic Assisted Repair of Rectal Prolapse |
| NCT01992406 | Not specified | UNKNOWN | Feasibility, Safety and Outcome of Transrectal Hybrid-NOTES Anterior Resection |
| NCT02609555 | Not specified | COMPLETED | TEM Assisted Perineal Rectopexy in Treatment of Rectal Prolapse |
| NCT02870192 | Not specified | UNKNOWN | Intra-operative Adverse Events During Laparoscopic Ventral Mesh Rectopexy |
| NCT02901210 | Not specified | COMPLETED | A Modified Technique to Facilitate Pealing of the Rectal Mucosa in Delorme Operation |
| NCT02971332 | Not specified | COMPLETED | Long Term Results of STARR With Contour Transtar |
| NCT03012464 | Not specified | UNKNOWN | Pathologic Assessment of Rectal Prolapse in the Young |
| NCT03026738 | Not specified | UNKNOWN | Anterior Versus Posterior Laparoscopic Mesh Rectopexy For Rectal Prolapse; a Randomized Controlled Trial. |
| NCT03060330 | Not specified | UNKNOWN | Laparoscopic Ventral Mesh Rectopexy Combined With or Without Stapled Trans-anal Rectal Resection for Obstructed Defecation Syndrome |
| NCT03643393 | Not specified | COMPLETED | Report 2 Cases of Massive Incarceration Necrosis Rectal Prolapse Are Successfully Treated With Altemeier’s Procedure |
| NCT03917056 | Not specified | UNKNOWN | Cap-assisted Endoscopic Sclerotherapy for Internal Hemorrhoids and Rectal Prolapse |
| NCT04117633 | Not specified | COMPLETED | Laparoscopic Suture Versus Mesh Rectopexy for the Treatment of Persistent Complete Rectal Prolapse in Children |
| NCT04130555 | Not specified | COMPLETED | Safety and Performance Evaluation of a Biological Matrix Used for Rectal Prolapse Repair by Ventral Rectopexy |
| NCT04184310 | Not specified | COMPLETED | Modified Perineal Linear Stapler Resection for External Rectal Prolapse: a Novel Approach |
| NCT04564677 | Not specified | UNKNOWN | A Study Evaluating the Clinical Outcome of a Modified d’Hoore Technique for Laparoscopic Ventral Mesh Rectopexy |
| NCT04627610 | Not specified | COMPLETED | Recurrence of Dyschezia in Rectal Prolapse, Rectocele and Elytrocele |
| NCT04817150 | Not specified | UNKNOWN | 3D vs 2D-laparoscopy for Rectocele and Rectal Prolapse Correction: a Prospective, Randomized, Single Center Study |
| NCT04892108 | Not specified | COMPLETED | Rectal Prolapse With ODS. STARR vs LVR. |
| NCT04893642 | Not specified | TERMINATED | Swedish Rectal Prolapse Trial |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| SODIUM CHLORIDE | 4 | 1 |
Related Atlas pages
- Drugs: Sodium Chloride