Rectosigmoid carcinoma
diseaseOn this page
Also known as carcinoma of rectosigmoid junctionrectosigmoid cancerrectosigmoid junction carcinoma
Summary
Rectosigmoid carcinoma (MONDO:0002424) is a cancer and 10 clinical trials. Top therapeutic interventions include leucovorin. A subtype of colon carcinoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 10
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | rectosigmoid carcinoma |
| Mondo ID | MONDO:0002424 |
| DOID | DOID:2781 |
| ICD-11 | 1415734886 |
| NCIT | C7421 |
| UMLS | C1327709 |
| MedGen | 232963 |
| Anatomy (UBERON) | UBERON:0036214 |
| Is cancer (heuristic) | yes |
Also known as: carcinoma of rectosigmoid junction · rectosigmoid cancer · rectosigmoid carcinoma · rectosigmoid junction carcinoma
Data availability: 8 cell lines.
Disease family
This is a subtype of colon carcinoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › large intestine disorder › colonic disorder › colonic neoplasm › malignant colon neoplasm › colon carcinoma › rectosigmoid carcinoma
Related subtypes (5): colon adenocarcinoma, colon small cell neuroendocrine carcinoma, colon carcinoma in situ, cecum carcinoma, squamous cell carcinoma of colon
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 10.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 8 |
| PHASE2 | 2 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT03043729 | PHASE2 | COMPLETED | mFOLFOX6 vs. mFOLFOX6 + Aflibercept as Neoadjuvant Treatment in MRI-defined T3-rectal Cancer |
| NCT04205955 | PHASE2 | COMPLETED | Testing Diet Intervention Versus Non-Diet Intervention for Management of Bowel Symptoms in Rectal Cancer Survivors |
| NCT02874885 | Not specified | ACTIVE_NOT_RECRUITING | Circulating Tumor Cells in Patients With Locally Advanced Rectal Cancer |
| NCT04037956 | Not specified | RECRUITING | Tubeless NOSES Versus Laparoscopic Radical Resection for Rectosigmoid Cancers |
| NCT04665635 | Not specified | RECRUITING | Rectosigmoid Resection vs Seromuscular Tumor Shaving in Ovarian Cancer Surgery |
| NCT05566249 | Not specified | RECRUITING | A Study to Validate the Safety and Feasibility of ArtiSential in Colorectal Cancer Surgery Using Prospectively Constructed Multi-center Registry |
| NCT05797064 | Not specified | NOT_YET_RECRUITING | Establishment of a Feasibility Model for NOSE Surgery Based on Machine Learning |
| NCT02205307 | Not specified | TERMINATED | A Study Assessing Perfusion Outcomes With PINPOINT® Near Infrared Fluorescence Imaging in Low Anterior Resection |
| NCT03063918 | Not specified | COMPLETED | Personalized Dietary Intervention in Managing Bowel Dysfunction and Improving Quality of Life in Stage I-III Rectosigmoid Cancer Survivors |
| NCT06435975 | Not specified | COMPLETED | Physical Activity in Rectal Cancer Survivors |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| LEUCOVORIN | 4 | 1 |
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.