Rectum neuroendocrine neoplasm
diseaseOn this page
Also known as NET of the rectumneuroendocrine neoplasm of rectumneuroendocrine neoplasm of the rectumneuroendocrine tumor of rectumneuroendocrine tumour of rectumrectal NETrectal neuroendocrine neoplasmrectal neuroendocrine tumorrectum NETrectum neuroendocrine tumorrectum neuroendocrine tumor, well differentiated, low or intermediate graderectum neuroendocrine tumour
Summary
Rectum neuroendocrine neoplasm (MONDO:0003646) is a cancer and 7 clinical trials. A subtype of intestinal neuroendocrine neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Phenotypes (HPO): 25
- Clinical trials: 7
Clinical features
Signs & symptoms
Clinical features (HPO)
25 HPO clinical features (Orphanet curated; top 25 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0100570 | Carcinoid tumor | Obligate (100%) |
| HP:0001824 | Weight loss | Frequent (30-79%) |
| HP:0002019 | Constipation | Frequent (30-79%) |
| HP:0002027 | Abdominal pain | Frequent (30-79%) |
| HP:0002039 | Anorexia | Frequent (30-79%) |
| HP:0002573 | Hematochezia | Frequent (30-79%) |
| HP:0012702 | Tenesmus | Frequent (30-79%) |
| HP:0025085 | Bloody diarrhea | Frequent (30-79%) |
| HP:0030144 | Hypoactive bowel sounds | Frequent (30-79%) |
| HP:0030446 | Atypical pulmonary carcinoid tumor | Frequent (30-79%) |
| HP:0002240 | Hepatomegaly | Occasional (5-29%) |
| HP:0002249 | Melena | Occasional (5-29%) |
| HP:0002730 | Chronic noninfectious lymphadenopathy | Occasional (5-29%) |
| HP:0002910 | Elevated circulating hepatic transaminase concentration | Occasional (5-29%) |
| HP:4000007 | Bronchoconstriction | Very rare (<1-4%) |
| HP:0001708 | Right ventricular failure | Very rare (<1-4%) |
| HP:0001962 | Palpitations | Very rare (<1-4%) |
| HP:0002615 | Hypotension | Very rare (<1-4%) |
| HP:0003144 | Increased serum serotonin | Very rare (<1-4%) |
| HP:0004385 | Protracted diarrhea | Very rare (<1-4%) |
| HP:0005180 | Tricuspid regurgitation | Very rare (<1-4%) |
| HP:0007380 | Facial telangiectasia | Very rare (<1-4%) |
| HP:0012701 | Bowel urgency | Very rare (<1-4%) |
| HP:0030145 | Lack of bowel sounds | Very rare (<1-4%) |
| HP:0031566 | Abnormal pulmonary valve cusp morphology | Very rare (<1-4%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | rectum neuroendocrine neoplasm |
| Mondo ID | MONDO:0003646 |
| Orphanet | 100081 |
| DOID | DOID:5777 |
| ICD-11 | 1619951900 |
| NCIT | C5698 |
| UMLS | C1335686 |
| MedGen | 277576 |
| GARD | 0019756 |
| Anatomy (UBERON) | UBERON:0001052 |
| Is cancer (heuristic) | yes |
Also known as: NET of the rectum · neuroendocrine neoplasm of rectum · neuroendocrine neoplasm of the rectum · neuroendocrine tumor of rectum · neuroendocrine tumour of rectum · rectal NET · rectal neuroendocrine neoplasm · rectal neuroendocrine tumor · rectum NET · rectum neuroendocrine neoplasm · rectum neuroendocrine tumor · rectum neuroendocrine tumor, well differentiated, low or intermediate grade · rectum neuroendocrine tumour
Data availability: 1 cell line.
Disease family
This is a subtype of intestinal neuroendocrine neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › intestinal neoplasm › intestinal neuroendocrine neoplasm › rectum neuroendocrine neoplasm
Related subtypes (3): colon neuroendocrine neoplasm, small intestine neuroendocrine neoplasm, intestinal neuroendocrine tumor G1
Subtypes (2): anal canal neuroendocrine neoplasm, rectal neuroendocrine tumor
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 7.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 7 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05429216 | Not specified | NOT_YET_RECRUITING | Endoscopic Resection for Small Rectal Neuroendocrine Tumors |
| NCT06279299 | Not specified | RECRUITING | Lateral Pelvic Lymph Node Dissection for Rectal Neuroendocrine Neoplasms Undergoing Laparoscopic Total Mesenteric Excision |
| NCT06901856 | Not specified | NOT_YET_RECRUITING | Endoscopic Resection for Small Rectal Neuroendocrine Tumors |
| NCT07373015 | Not specified | NOT_YET_RECRUITING | Modified Double Snare Assisted EMR (mDS-EMR) VS ESD for Rectal Neuroendocrine Tumors Smaller Than 1cm |
| NCT07410767 | Not specified | NOT_YET_RECRUITING | Advanced Endoscopic Resections for Rectal Neoplasms |
| NCT07612748 | Not specified | NOT_YET_RECRUITING | Two Different Endoscopic Treatments for Rectal Neuroendocrine Neoplasms |
| NCT03982264 | Not specified | UNKNOWN | Endoscopic Treatment of Rectal Neuroendocrine Tumor(NET) Less Than 10mm |
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.