Recurrent acute pancreatitis

Summary

Recurrent acute pancreatitis (MONDO:0018989) is a disease and 13 clinical trials. Top therapeutic interventions include pirfenidone. A subtype of pancreas disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 13

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	recurrent acute pancreatitis
Mondo ID	MONDO:0018989
Orphanet	64740
ICD-11	300900170
NCIT	C184324
SNOMED CT	197458008
UMLS	C0267937
MedGen	489943
MedDRA	10033657
Is cancer (heuristic)	no

Disease family

This is a subtype of pancreas disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › pancreas disorder › recurrent acute pancreatitis

Related subtypes (13): pancreatic steatorrhea, pancreatic mucinous ductal ectasia, exocrine pancreatic insufficiency, endocrine pancreas disorder, pancreatitis, annular pancreas, pancreatic triacylglycerol lipase deficiency, follicular cholangitis and pancreatitis, congenital pancreatic cyst, accessory pancreas, pancreatic neoplasm, acinar cystic transformation of the pancreas, lymphoepithelial cyst of the pancreas

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 13.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	7
PHASE1/PHASE2	2
PHASE2	2
PHASE4	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07418593	PHASE4	RECRUITING	Malabsorption Blood Test (MBT) to Determine Exocrine Pancreatic Function and Related Quality of Life in Chronic Pancreatitis
NCT05453851	PHASE1/PHASE2	NOT_YET_RECRUITING	A Surgical Procedure (Total Pancreatectomy) With a Transplant Procedure (Islet Cell Autotransplantation) for the Treatment of Chronic Pancreatitis and Benign Pancreatic Tumors
NCT06253117	PHASE2	RECRUITING	Evaluation of Pirfenidone as a Novel Therapeutic Strategy Against Recurrent Acute Pancreatitis.
NCT07171112	PHASE2	RECRUITING	Smoking Cessation Trial in Recurrent Acute Pancreatitis and Chronic Pancreatitis
NCT07447687	PHASE1/PHASE2	RECRUITING	Soy Tomato Juice to Improve Outcomes in Pancreatitis
NCT05771675	EARLY_PHASE1	RECRUITING	Simvastatin Treatment to Improve Patient-reported Outcomes in Patients With Chronic Pancreatitis
NCT04647097	Not specified	RECRUITING	Preventing the Recurrence of Acute Pancreatitis by Alcohol and Smoking Cessation
NCT06185621	Not specified	RECRUITING	The Effect of Aspirin on Recurrent Acute Pancreatitis
NCT06355206	Not specified	RECRUITING	Natural Course and Therapeutic Effect of Recurrent Acute Pancreatitis
NCT06364397	Not specified	RECRUITING	Efficacy of ERCP in the Diagnosis and Treatment of Idiopathic Recurrent Acute Pancreatitis
NCT06651580	Not specified	RECRUITING	Biospecimen Collection to Identify Gene Mutations for High Risk Pancreatic Cancer in Pediatric Patients, INSPPIRE 2 Study
NCT00523874	Not specified	COMPLETED	Recurrence of Acute Alcoholic Pancreatitis
NCT01583517	Not specified	COMPLETED	ERCP in Idiopathic Recurrent Acute Pancreatitis

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
PIRFENIDONE	4	1