Regional odontodysplasia

disease

On this page

Also known as ghost teeth

Summary

Regional odontodysplasia (MONDO:0019367) is a disease. A subtype of periodontal disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

Prevalence: Unknown (Worldwide) [Orphanet-validated]
Phenotypes (HPO): 24

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Cases/families		140	Worldwide	Validated

Signs & symptoms

Clinical features (HPO)

24 HPO clinical features (Orphanet curated; top 24 by frequency):

HPO ID	Term	Frequency
HP:0000230	Gingivitis	Frequent (30-79%)
HP:0000670	Carious teeth	Frequent (30-79%)
HP:0000682	Abnormality of dental enamel	Frequent (30-79%)
HP:0000684	Delayed eruption of teeth	Frequent (30-79%)
HP:0000694	Odontodysplasia	Frequent (30-79%)
HP:0000706	Unerupted tooth	Frequent (30-79%)
HP:0003771	Pulp calcification	Frequent (30-79%)
HP:0006286	Yellow-brown discoloration of the teeth	Frequent (30-79%)
HP:0006297	Enamel hypoplasia	Frequent (30-79%)
HP:0006479	Abnormality of the dental pulp	Frequent (30-79%)
HP:0006481	Abnormality of primary teeth	Frequent (30-79%)
HP:0009722	Dental enamel pits	Frequent (30-79%)
HP:0010299	Abnormality of dentin	Frequent (30-79%)
HP:0011073	Abnormality of dental color	Frequent (30-79%)
HP:0011084	Hypocalcification of dental enamel	Frequent (30-79%)
HP:0030757	Tooth abscess	Frequent (30-79%)
HP:0040264	Jaw pain	Frequent (30-79%)
HP:0000212	Gingival overgrowth	Occasional (5-29%)
HP:0000685	Hypoplasia of teeth	Occasional (5-29%)
HP:0001572	Macrodontia	Occasional (5-29%)
HP:0006283	Multiple unerupted teeth	Occasional (5-29%)
HP:0006336	Short dental roots	Occasional (5-29%)
HP:0009085	Alveolar ridge overgrowth	Occasional (5-29%)
HP:0200025	Mandibular pain	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	regional odontodysplasia
Mondo ID	MONDO:0019367
MeSH	D018126
Orphanet	83450
ICD-11	1516505714
SNOMED CT	66063001
UMLS	C0206554
MedGen	104891
GARD	0019036
Is cancer (heuristic)	no

Also known as: ghost teeth

Disease family

This is a subtype of periodontal disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › periodontal disorder › regional odontodysplasia

Related subtypes (3): gingival disorder, periodontitis, Papillon-Lefevre disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.