Resistant hypertension
diseaseOn this page
Also known as drug resistant hypertension
Summary
Resistant hypertension (MONDO:0100078) is a disease and 69 clinical trials. Top therapeutic interventions include spironolactone, amiloride, and aprocitentan. A subtype of hypertensive disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 69
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | resistant hypertension |
| Mondo ID | MONDO:0100078 |
| Is cancer (heuristic) | no |
Also known as: drug resistant hypertension
Disease family
This is a subtype of hypertensive disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › vascular disorder › arterial disorder › hypertensive disorder › resistant hypertension
Related subtypes (11): essential hypertension, secondary hypertension, pulmonary hypertension, early onset hypertension, chemotherapy-induced hypertension, intracranial hypertension, malignant hypertension, ocular hypertension, kallikrein hypertension, hypertension, pregnancy-induced, hypertensive urgency
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 69.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 45 |
| PHASE3 | 9 |
| PHASE2 | 7 |
| PHASE4 | 4 |
| PHASE1 | 2 |
| PHASE2/PHASE3 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01508754 | PHASE4 | COMPLETED | Efficacy of CPAP Treatment on Blood Pressure of Resistant Hypertension Patients With Obstructive Sleep Apnea Syndrome |
| NCT01734096 | PHASE4 | COMPLETED | Renal Response to Lower Body Negative Pressure in Pre-hypertensive States |
| NCT01918111 | PHASE4 | TERMINATED | Effects of REnal Denervation for Resistant Hypertension on Exercise Diastolic Function and Regression of Atherosclerosis and the Evaluation of NEW Methods Predicting A successfuL Renal Sympathetic Denervation (RENEWAL-EXERCISE, -REGRESS, and -PREDICT Trial From RENEWAL RDN Registry) |
| NCT04331691 | PHASE4 | COMPLETED | Comparison of Spironolactone and Amiloride on Home Blood Pressure in Resistant Hypertension |
| NCT07232966 | PHASE3 | NOT_YET_RECRUITING | Perirenal Adipose Tissue Modification Therapy for Resistant Hypertension |
| NCT01522430 | PHASE3 | UNKNOWN | Study of Catheter Based Renal Denervation Therapy in Hypertension |
| NCT01874470 | PHASE3 | TERMINATED | Renal Denervation by Allegro System in Patients With Resistant Hypertension |
| NCT01939392 | PHASE2/PHASE3 | WITHDRAWN | Rapid Renal Sympathetic Denervation for Resistant Hypertension II |
| NCT03541174 | PHASE3 | COMPLETED | A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High Blood Pressure (Hypertension) and Find Out More About Its Safety |
| NCT04478500 | PHASE3 | UNKNOWN | Neuroinflammation in Hypertension Study |
| NCT05545059 | PHASE3 | UNKNOWN | Effects and Safety of Sacubitril/Valsartan on Refractory Hypertension |
| NCT06034743 | PHASE3 | COMPLETED | A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension |
| NCT06168409 | PHASE3 | COMPLETED | A Study to Investigate the Effect of Baxdrostat on Ambulatory Blood Pressure in Participants With Resistant Hypertension |
| NCT06344104 | PHASE3 | COMPLETED | A Study to Investigate the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension |
| NCT04388124 | PHASE2 | RECRUITING | Endothelin-1 Receptor Blockade in Resistant Hypertension |
| NCT05888233 | PHASE2 | ACTIVE_NOT_RECRUITING | Allopurinol Improves Heart Function in African Americans With Resistant Hypertension |
| NCT00272961 | PHASE2 | TERMINATED | A Study Of Different Doses Of TBC3711 In Patients With Uncontrolled High Blood Pressure Already Taking Medications For High Blood Pressure. |
| NCT03071263 | PHASE2 | COMPLETED | Spironolactone With Patiromer in the Treatment of Resistant Hypertension in Chronic Kidney Disease |
| NCT04519658 | PHASE2 | COMPLETED | A Study of CIN-107 in Adults With Treatment-Resistant Hypertension (rHTN) |
| NCT04637152 | PHASE2 | COMPLETED | Sacubitril/Valsartan in Resistant Hypertension |
| NCT05562934 | PHASE2 | COMPLETED | An Efficacy, Safety, Tolerability and Dose Finding Study of XXB750 in Resistant Hypertension Patients. |
| NCT05247528 | PHASE1 | COMPLETED | Safety And Tolerability Of Subcutaneous MANP In Difficult To Control/Resistant Hypertensive Subjects |
| NCT06183671 | PHASE1 | UNKNOWN | JX09 SAD/MAD in Healthy Participants |
| NCT06169241 | EARLY_PHASE1 | RECRUITING | Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients |
| NCT03179800 | Not specified | ACTIVE_NOT_RECRUITING | CALM- 2 - Controlling and Lowering Blood Pressure With the MobiusHD™ |
| NCT05563077 | Not specified | ACTIVE_NOT_RECRUITING | Aerobic Exercise and Resistant Hypertension |
| NCT05925569 | Not specified | ACTIVE_NOT_RECRUITING | Electronic Alert to Improve Testing For Primary Aldosteronism in Patients With Hypertension |
| NCT05994729 | Not specified | NOT_YET_RECRUITING | Impact of Renal Denervation in Patients With Coronary Microvascular Dysfunction: Study Design and Rationale |
| NCT06216808 | Not specified | RECRUITING | A First-in-human Study of HyperQureTM, Laparoscopic Renal Denervation Therapy in Patient With Resistant Hypertension |
| NCT06228677 | Not specified | RECRUITING | Comparison of Catecholamine Concentrations in Venous Blood During Selective Adrenal Artery Embolization |
| NCT06282107 | Not specified | NOT_YET_RECRUITING | Effectiveness and Safety of BiSAAE for Resistant Hypertension. |
| NCT06450327 | Not specified | RECRUITING | Resistant Hypertension An Open, Complicated (Cum Plicare) or Complex (Cum Plexus) Syndrome? |
| NCT06515795 | Not specified | RECRUITING | Evaluation of Two Isometric Exercises in the Reduction of the Blood Pressure in People With Resistant Hypertension |
| NCT06526858 | Not specified | RECRUITING | Early Feasibility Study of HyperQureTM RDN System, Laparoscopic Renal Denervation Therapy, in Patients With Resistant Hypertension |
| NCT06780696 | Not specified | NOT_YET_RECRUITING | SMART Study in Real World |
| NCT06819241 | Not specified | NOT_YET_RECRUITING | Self-Management of Blood Pressure in Resistant Hypertension |
| NCT06880562 | Not specified | NOT_YET_RECRUITING | The RESPLASH Study |
| NCT07081243 | Not specified | RECRUITING | Symplicity China Study |
| NCT07207226 | Not specified | ACTIVE_NOT_RECRUITING | Arterial Stiffness as a Tool to Investigate Adherence in Resistant Hypertension |
| NCT07383220 | Not specified | RECRUITING | Effect of Electrical Stimulation and Exercise on Blood Flow in Patients With Resistant High Blood Pressure |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| SPIRONOLACTONE | 4 | 3 |
| AMILORIDE | 4 | 1 |
| APROCITENTAN | 4 | 1 |
| BOSENTAN | 4 | 1 |
| CANDESARTAN CILEXETIL | 4 | 1 |
| CHLORTHALIDONE | 4 | 1 |
| MINOCYCLINE | 4 | 1 |
| SACUBITRIL | 4 | 1 |
| BAXDROSTAT | 3 | 4 |
| PATIROMER | 3 | 1 |
| CHEMBL1562223 | 0 | 1 |
| CHEMBL30458 | 0 | 1 |
| CHEMBL402262 | 0 | 1 |