Respiratory paralysis

Summary

Respiratory paralysis (MONDO:0043775) is a disease and 26 clinical trials. Top therapeutic interventions include ropivacaine and levobupivacaine. A subtype of diaphragm disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 26

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	respiratory paralysis
Mondo ID	MONDO:0043775
MeSH	D012133
SNOMED CT	64228003
UMLS	C0035232
MedGen	19748
GARD	0025868
Is cancer (heuristic)	no

Also known as: diaphragmatic paralysis · muscle paralysis, respiratory · muscle paralyzes, respiratory · paralysis of diaphragm · paralysis, diaphragmatic · paralysis, respiratory · paralysis, respiratory muscle · respiratory muscle paralysis

Disease family

This is a subtype of diaphragm disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › respiratory system disorder › diaphragm disorder › respiratory paralysis

Related subtypes (4): congenital diaphragmatic hernia, diaphragmatic eventration, diaphragmitis, diaphragmatic malformation

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 26.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	24
PHASE3	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04173364	PHASE3	COMPLETED	Interscalene Block and Dysfunction Diaphragmatic
NCT04385966	PHASE3	COMPLETED	Diaphragmatic Paralysis Comparison Between Local Anesthetic Volumen Doses After Interscalene Block
NCT06243718	Not specified	RECRUITING	Phrenic Nerve Reconstruction for the Treatment of Diaphragmatic Paralysis: Patient Experiences and Reported Outcomes.
NCT06257589	Not specified	ACTIVE_NOT_RECRUITING	A Chart Review to Evaluate the Safety and Efficacy of Phrenic Nerve Reconstruction for the Treatment of Diaphragmatic Paralysis
NCT06538376	Not specified	RECRUITING	Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU
NCT06919185	Not specified	NOT_YET_RECRUITING	Short- and Long-term Effects of Robot-assisted Plication in Diaphragmatic Paralysis
NCT07612514	Not specified	NOT_YET_RECRUITING	Optimized Costoclavicular Block for Elderly Proximal Humeral Fracture Surgery
NCT00597298	Not specified	COMPLETED	Diaphragm Training Post-Cardiac Surgery
NCT01385384	Not specified	COMPLETED	Diaphragmatic Pacemaker in Tetraplegic Patients With Spinal Cord Injuries
NCT01450917	Not specified	COMPLETED	Diaphragmatic Height Index: the New Diagnostic Test for Phrenic Nerve Dysfunction
NCT01569217	Not specified	UNKNOWN	Regional Distribution of Ventilation to Assess Respiratory Muscle Dysfunction
NCT01968889	Not specified	COMPLETED	ICU Acquired Neuromyopathy and Diaphragm Function
NCT02126852	Not specified	COMPLETED	Comparison of AMG and EMG to Avoid Residual Paralysis After General Anesthesia
NCT02942953	Not specified	COMPLETED	Diaphragmatic Pacer Placement: Anesthetic Management (DP)
NCT03032562	Not specified	UNKNOWN	Respiratory Muscle Strength and Function in Neuromuscular Disorders and Chronic Obstructive Pulmonary Disease
NCT03224884	Not specified	COMPLETED	Interscalene Block Versus Supraclavicular Block for Shoulder Surgery
NCT03411343	Not specified	COMPLETED	Interscalene Block Versus Costoclavicular Block for Shoulder Surgery
NCT03463798	Not specified	COMPLETED	Assesment of New Devices for the Diagnostic Evaluation of Diaphragmatic Dysfunction
NCT03592056	Not specified	TERMINATED	Hemidiaphragmatic Paralysis With Diluted Continuous Interscalene Plexus Infusions
NCT03802383	Not specified	UNKNOWN	The Relationship Between Trans-diaphragmatic Pressure and Diaphragmatic Contraction
NCT04317235	Not specified	COMPLETED	Ultrasound-guided Interscalene Block:3mL Ropi Provide Similar Analgesia to 5mL and Less Diaphragmatic Paralysis
NCT04563468	Not specified	COMPLETED	Effects of Inspiratory Muscle Training on Exertional Breathlessness in Patients With Unilateral Diaphragm Paralysis
NCT05442814	Not specified	COMPLETED	Anterior and Posterior Approaches of Suprascapular Nerve Block
NCT05444517	Not specified	COMPLETED	Interscalene Block Versus Combined Infraclavicular-Anterior Suprascapular Blocks for Shoulder Surgery
NCT06146179	Not specified	COMPLETED	Combined Anterior Suprascapular Nerve Block and Superficial Cervical Plexus Block In Shoulder Arthroplasty Surgery
NCT06766045	Not specified	COMPLETED	Comparison of Ultrasound with Fluoroscopy to Assess Diaphragmatic Paralysis After Congenital Heart Disease Surgery

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ROPIVACAINE	4	2
LEVOBUPIVACAINE	4	1