Restrictive pulmonary disease

Summary

Restrictive pulmonary disease (MONDO:0600029) is a disease and 14 clinical trials. Top therapeutic interventions include sodium chloride. A subtype of lung disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 14

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	restrictive pulmonary disease
Mondo ID	MONDO:0600029
NCIT	C91762
SNOMED CT	36485005
UMLS	C0085581
MedGen	43209
Is cancer (heuristic)	no

Also known as: restrictive lung disease · Restrictive lung disease (disorder)

Disease family

This is a subtype of lung disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › respiratory system disorder › lower respiratory tract disorder › lung disorder › restrictive pulmonary disease

Related subtypes (32): aspiration pneumonia, lung abscess, pneumonic plague, pulmonary alveolar proteinosis, pulmonary systemic sclerosis, obstructive lung disease, bronchiolitis, pulmonary immaturity, rheumatoid arthritis-associated interstitial lung disease, pulmonary embolism and infarction, acute chest syndrome, fungal lung infectious disease, middle lobe syndrome, pulmonary coin lesion, pulmonary plasma cell granuloma, silo filler disease, pulmonary alveolar microlithiasis, pulmonary venoocclusive disease, acute lung injury, interstitial lung disease, hantavirus pulmonary syndrome, pulmonary non-tuberculous mycobacterial infection, respiratory failure, lung neoplasm, occupational lung disease, Wilson-Mikity syndrome, neonatal aspiration syndrome, pneumonitis, vanishing lung syndrome, shrinking lung syndrome, dystrophic pulmonary ossification, pulmonary artery disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 14.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	12
PHASE4	1
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02843698	PHASE4	COMPLETED	Effects of Dexmedetomidine on Oxygenation and Lung Mechanics in Morbidly Obese Patients Undergoing Bariatric Operations
NCT00687349	PHASE3	COMPLETED	Improving Clinician Communication Skills (ICCS)
NCT04941326	Not specified	RECRUITING	The Effect of Spinal Mobilization on Respiratory Parameters in Parkinson’s Disease Patients
NCT06911476	Not specified	NOT_YET_RECRUITING	From Inflammation to Remodelling Towards Personalized Diagnosis in Post-acute Sequelae of COVID-19
NCT07012733	Not specified	NOT_YET_RECRUITING	Thoracic Mobilization for Restrictive Lung Disease
NCT01601288	Not specified	COMPLETED	Database of All Patients Who Have Undergone Pulmonary Function Testing at Singapore General Hospital
NCT01762917	Not specified	COMPLETED	Influence of Bag Volume Variation on the Reproducibility of Inert Gas Rebreathing
NCT02245178	Not specified	COMPLETED	Lung Function Decline and Disease Risk From Young Adulthood to Middle Age
NCT03506906	Not specified	COMPLETED	The Debated Role of Sleep Studies in Patients Under Established Home Mechanical Ventilation
NCT04136795	Not specified	UNKNOWN	Evaluation of the Respiratory Impact After Conventional or Minimally Invasive Esophageal Atresia Surgery
NCT04143776	Not specified	WITHDRAWN	Renal- and Pulmonary Function in Relation to Abdominal Hypertension After Abdominal Reconstruction
NCT04668599	Not specified	COMPLETED	Cardio-pulmonary Rehabilitation and Sleep Quality
NCT04881214	Not specified	UNKNOWN	COVID-19 Pneumonia: Pulmonary Physiology, Health-related Quality of Life and Benefit of a Rehabilitation Program
NCT05119491	Not specified	COMPLETED	Relation Between Pulmonary Function Tests and Ultrasonographic Chest Joints

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
SODIUM CHLORIDE	4	1