Retina neoplasm
diseaseOn this page
Also known as neoplasm of retinaneoplasm of the retinaretina neoplasm (disease)retina tumorretina tumourretinal neoplasmretinal tumorretinal tumourtumor of retinatumor of the retinatumour of retinatumour of the retina
Summary
Retina neoplasm (MONDO:0021231) is a cancer (an umbrella term covering 5 Mondo subtypes) and 3 clinical trials. Top therapeutic interventions include carboplatin, doxorubicin, and etoposide phosphate. A subtype of retinal disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Umbrella term: 5 Mondo subtypes
- Clinical trials: 3
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | retina neoplasm |
| Mondo ID | MONDO:0021231 |
| EFO | EFO:1000509 |
| NCIT | C4800 |
| UMLS | C0524801 |
| MedGen | 101180 |
| Anatomy (UBERON) | UBERON:0000966 |
| Is cancer (heuristic) | yes |
Also known as: neoplasm of retina · neoplasm of the retina · retina neoplasm (disease) · retina tumor · retina tumour · retinal neoplasm · retinal tumor · retinal tumour · tumor of retina · tumor of the retina · tumour of retina · tumour of the retina
Disease family
This is a subtype of retinal disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › retinal disorder › retina neoplasm
Related subtypes (31): retinal ischemia, rubeosis iridis, retinal vascular disorder, retinitis, retinal nerve fiber layer disorder, retinal edema, retinal degeneration, night blindness, hypertensive retinopathy, macular holes, retinal detachment, iris hypoplasia with glaucoma, angioid streaks, bradyopsia, myopic macular degeneration, osteogenesis imperfecta-retinopathy-seizures-intellectual disability syndrome, congenital retinal arteriovenous communication, Eales disease, central serous chorioretinopathy, achromatopsia, cancer-associated retinopathy, persistent placoid maculopathy, inherited vitreoretinopathy, retinal ciliopathy, melanoma associated retinopathy, isolated foveal hypoplasia, acute macular neuroretinopathy, autoimmune retinopathy, proliferative vitreoretinopathy, isolated chorioretinal dystrophy, torpedo maculopathy
Subtypes (5): retinal cancer, retinal capillary malformation, benign neoplasm of retina, retinal neuroblastoma, retinal cell neoplasm
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
No approved or late-stage (phase ≥3) drug is indicated for this disease; the following are in earlier-phase trials only.
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Carboplatin, Melphalan.
Clinical trials & evidence
Clinical trials
Clinical trials: 3.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE2 | 2 |
| PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00186888 | PHASE3 | COMPLETED | Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma |
| NCT02866136 | PHASE2 | ACTIVE_NOT_RECRUITING | Conservative Treatments of Retinoblastoma |
| NCT00179920 | PHASE2 | COMPLETED | Chemotherapy Treatment for Children With Intraocular Germ-Line Retinoblastoma |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CARBOPLATIN | 4 | 3 |
| DOXORUBICIN | 4 | 2 |
| ETOPOSIDE PHOSPHATE | 4 | 2 |
| TOPOTECAN | 4 | 1 |
| VINCRISTINE | 4 | 1 |