Retroperitoneal cancer

Summary

Retroperitoneal cancer (MONDO:0005941) is a cancer and 8 clinical trials. Top therapeutic interventions include alemtuzumab and eribulin mesylate. A subtype of cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 8

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	retroperitoneal cancer
Mondo ID	MONDO:0005941
EFO	EFO:0007466
MeSH	D012186
DOID	DOID:5875
ICD-11	1731312506
NCIT	C3537
SNOMED CT	126872008
UMLS	C0153465
MedGen	57559
Anatomy (UBERON)	UBERON:0003693
Is cancer (heuristic)	yes

Also known as: cancer of retroperitoneal space · malignant neoplasm of retroperitoneal space · malignant neoplasm of retroperitoneum · malignant neoplasm of retroperitoneum and peritoneum · malignant retroperitoneal neoplasm · malignant retroperitoneal space neoplasm · malignant tumour of peritoneum and retroperitoneum · neoplasm of retroperitoneum · neoplasm of the retroperitoneum · retroperitoneal neoplasm · retroperitoneal space cancer · tumor of retroperitoneum · tumour of retroperitoneum

Disease family

This is a subtype of cancer. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › retroperitoneal cancer

Related subtypes (32): respiratory system cancer, immune system cancer, musculoskeletal system cancer, integumentary system cancer, peritoneum cancer, cardiovascular cancer, reproductive system cancer, malignant giant cell tumor, digestive system cancer, lipomatous cancer, thoracic cancer, malignant glomus tumor, malignant mesenchymoma, carcinoma, sarcoma, blastoma, head and neck cancer, malignant mixed neoplasm, nervous system cancer, malignant germ cell tumor, malignant mesothelioma, malignant urinary system neoplasm, childhood malignant neoplasm, anaplastic cancer, malignant spindle cell neoplasm, high grade malignant neoplasm, malignant endocrine neoplasm, malignant soft tissue neoplasm, secondary malignant neoplasm, refractory malignant neoplasm, malignant adenoma, cancer of unknown primary site

Subtypes (4): retroperitoneal lymphoma, retroperitoneal sarcoma, retroperitoneum carcinoma, adrenal gland cancer

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 8.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	4
PHASE1	3
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06084780	PHASE2	NOT_YET_RECRUITING	Intestinal & Multivisceral Transplantation for Unresectable Mucinous Carcinoma Peritonei (TRANSCAPE)
NCT03361436	PHASE1	ACTIVE_NOT_RECRUITING	Eribulin and Radiation Therapy in Treating Patients With Retroperitoneal Liposarcoma That Can Be Removed by Surgery
NCT00436657	PHASE1	COMPLETED	Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin for Children With Peritoneal Cancer
NCT03508570	PHASE1	COMPLETED	Nivolumab With or Without Ipilimumab in Treating Patients With Recurrent or High Grade Gynecologic Cancer With Metastatic Peritoneal Carcinomatosis
NCT06634706	Not specified	NOT_YET_RECRUITING	SCINTIX [BgRT} Using RMRS in Solid and Soft Tissue Tumors
NCT06803251	Not specified	RECRUITING	The Role of the Vascular Surgeon in Oncologic Surgery of Abdominal and Pelvic Retroperitoneal Masses
NCT03480399	Not specified	UNKNOWN	Long Term Morbidity and Quality of Life in Retroperitoneal Sarcomas
NCT05659433	Not specified	COMPLETED	Contrast-enhanced vs. B-mode Ultrasound-guided Percutaneous Biopsy of Retroperitoneal Tumors

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ALEMTUZUMAB	4	1
ERIBULIN MESYLATE	4	1