Retroperitoneal sarcoma
diseaseOn this page
Also known as retroperitoneal space sarcomasarcoma of retroperitoneal space
Summary
Retroperitoneal sarcoma (MONDO:0001501) is a cancer and 28 clinical trials. Top therapeutic interventions include doxorubicin, ifosfamide, and niraparib tosylate monohydrate. A subtype of retroperitoneal cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 28
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | retroperitoneal sarcoma |
| Mondo ID | MONDO:0001501 |
| DOID | DOID:12341 |
| NCIT | C4832 |
| SNOMED CT | 307219002 |
| UMLS | C0585129 |
| MedGen | 107937 |
| GARD | 0022958 |
| Anatomy (UBERON) | UBERON:0003693 |
| Is cancer (heuristic) | yes |
Also known as: retroperitoneal sarcoma · retroperitoneal space sarcoma · sarcoma of retroperitoneal space
Disease family
This is a subtype of retroperitoneal cancer. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › retroperitoneal cancer › retroperitoneal sarcoma
Related subtypes (3): retroperitoneal lymphoma, retroperitoneum carcinoma, adrenal gland cancer
Subtypes (1): retroperitoneal leiomyosarcoma
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 28.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 16 |
| PHASE2 | 3 |
| PHASE1 | 3 |
| PHASE3 | 2 |
| PHASE1/PHASE2 | 2 |
| PHASE4 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05844813 | PHASE4 | ENROLLING_BY_INVITATION | Neoadjuvant Chemotherapy Combined With Targeted Treatment in High-risk Retroperitoneal Sarcoma |
| NCT04031677 | PHASE3 | RECRUITING | Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma |
| NCT06480396 | PHASE3 | NOT_YET_RECRUITING | High Versus Lower Intensity Surveillance Following Resection of Retroperitoneal Sarcoma |
| NCT01659203 | PHASE1/PHASE2 | RECRUITING | Proton or Photon RT for Retroperitoneal Sarcomas |
| NCT04189783 | PHASE2 | ACTIVE_NOT_RECRUITING | Repeat or Single Quadratus Lumborum Block for the Reduction of Opioid Prescriptions After Surgery in Retroperitoneal Sarcoma Patients (RESQU-SARC Trial) |
| NCT06327477 | PHASE1/PHASE2 | RECRUITING | Proton-Spatially Fractionated Radiotherapy and Standard Radiation Therapy for the Treatment of Newly Diagnosed Retroperitoneal Soft Tissue Sarcoma |
| NCT05174455 | PHASE2 | WITHDRAWN | Niraparib for the Treatment of Leiomyosarcoma |
| NCT05302570 | PHASE2 | WITHDRAWN | Neoadjuvant Short-course Hypofractionated PBT for Non-metastatic RPS |
| NCT04420975 | PHASE1 | ACTIVE_NOT_RECRUITING | Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma |
| NCT06025747 | PHASE1 | RECRUITING | Evaluation of Abemaciclib and Radiation Therapy Before Surgery for the Treatment of High-Risk Adipocytic Retroperitoneal Sarcoma |
| NCT06812052 | PHASE1 | RECRUITING | Short Course Radiation Treatment for Patients With Primary or Locally Recurrent Retroperitoneal Sarcoma Prior to Surgery |
| NCT02384473 | EARLY_PHASE1 | COMPLETED | Real-Time Contrast-Enhanced Ultrasonography and Shear Wave Elastography in Predicting Treatment Response in Patients With Soft Tissue Sarcoma |
| NCT03838718 | Not specified | RECRUITING | REtroperitoneal SArcoma Registry: an International Prospective Initiative |
| NCT05224934 | Not specified | RECRUITING | Preoperative Ultra-hypofractionated Radiotherapy Followed by Surgery for Retroperitoneal Sarcoma (FUSION-01) |
| NCT06612671 | Not specified | ACTIVE_NOT_RECRUITING | Treatment Outcomes of Retroperitoneal Sarcoma |
| NCT06741423 | Not specified | ACTIVE_NOT_RECRUITING | Distinguishing Retroperitoneal Fibrosis and Sarcoma from Other Retroperitoneal Diseases Via Radiomics |
| NCT06753136 | Not specified | RECRUITING | Electrochemotherapy (ECT) in Patients With Primary Visceral Tumors and/or Secondary Visceral Localizations, of Any Histotype |
| NCT06943612 | Not specified | RECRUITING | Colorectal Resections in Patients With Retroperitoneal Sarcoma |
| NCT07396116 | Not specified | NOT_YET_RECRUITING | Preoperative Hypofractionated RT + Immunotherapy & Surgery for Retroperitoneal Sarcoma (FUSION-02) |
| NCT07432932 | Not specified | RECRUITING | Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients |
| NCT00901836 | Not specified | TERMINATED | Preoperative Proton Radiotherapy for Retroperitoneal Sarcoma |
| NCT03792867 | Not specified | UNKNOWN | Radical Resection and HIPEC for Recurrent Retroperitoneal Sarcoma |
| NCT03877588 | Not specified | COMPLETED | Nutritional Status in Retroperitoneal Sarcoma. |
| NCT04224948 | Not specified | COMPLETED | The PET- Retroperitoneal Sarcoma Study |
| NCT04225494 | Not specified | COMPLETED | Perioperative Residual Adrenal Function After Extended Resection for Retroperitoneal Soft Tissue Sarcomas |
| NCT05044624 | Not specified | COMPLETED | Retroperıtoneal Soft-Tıssue Sarcomas |
| NCT05631379 | Not specified | COMPLETED | Influence of Nutritional Status on Oncologic and Operative Outcome in Patients Operated for Retroperitoneal Sarcoma |
| NCT06396962 | Not specified | COMPLETED | Survival and Prognostic Factors of Primary Retroperitoneal Sarcomas After Surgery: a Single-center Experience |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| DOXORUBICIN | 4 | 3 |
| IFOSFAMIDE | 4 | 1 |
| NIRAPARIB TOSYLATE MONOHYDRATE | 4 | 1 |
| PERFLUTREN | 4 | 1 |