Rift valley fever

Summary

Rift valley fever (MONDO:0017880) is a disease and 11 clinical trials. Top therapeutic interventions include sodium chloride and rabies vaccine. A subtype of viral hemorrhagic fever — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: <1 / 1 000 000 (Europe) [Orphanet-validated]
• Phenotypes (HPO): 44
• Clinical trials: 11

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Annual incidence	<1 / 1 000 000		Europe	Validated

Signs & symptoms

Clinical features (HPO)

44 HPO clinical features (Orphanet curated; top 44 by frequency):

HPO ID	Term	Frequency
HP:0001945	Fever	Very frequent (80-99%)
HP:0003237	Increased circulating IgG level	Very frequent (80-99%)
HP:0020071	Viremia	Very frequent (80-99%)
HP:0002039	Anorexia	Frequent (30-79%)
HP:0000478	Abnormality of the eye	Occasional (5-29%)
HP:0000573	Retinal hemorrhage	Occasional (5-29%)
HP:0000575	Scotoma	Occasional (5-29%)
HP:0000613	Photophobia	Occasional (5-29%)
HP:0001324	Muscle weakness	Occasional (5-29%)
HP:0003496	Increased circulating IgM level	Occasional (5-29%)
HP:0007663	Reduced visual acuity	Occasional (5-29%)
HP:0025188	Retinal vasculitis	Occasional (5-29%)
HP:0032118	Retinitis	Occasional (5-29%)
HP:0032323	Periodic fever	Occasional (5-29%)
HP:0200026	Ocular pain	Occasional (5-29%)
HP:0000225	Gingival bleeding	Very rare (<1-4%)
HP:0000554	Uveitis	Very rare (<1-4%)
HP:0000738	Hallucinations	Very rare (<1-4%)
HP:0000790	Hematuria	Very rare (<1-4%)
HP:0000952	Jaundice	Very rare (<1-4%)
HP:0000988	Skin rash	Very rare (<1-4%)
HP:0001269	Hemiparesis	Very rare (<1-4%)
HP:0001873	Thrombocytopenia	Very rare (<1-4%)
HP:0001892	Abnormal bleeding	Very rare (<1-4%)
HP:0001903	Anemia	Very rare (<1-4%)
HP:0001977	Abnormal thrombosis	Very rare (<1-4%)
HP:0002248	Hematemesis	Very rare (<1-4%)
HP:0002249	Melena	Very rare (<1-4%)
HP:0002315	Headache	Very rare (<1-4%)
HP:0002321	Vertigo	Very rare (<1-4%)
HP:0002383	Infectious encephalitis	Very rare (<1-4%)
HP:0002385	Paraparesis	Very rare (<1-4%)
HP:0002910	Elevated circulating hepatic transaminase concentration	Very rare (<1-4%)
HP:0003418	Back pain	Very rare (<1-4%)
HP:0003470	Paralysis	Very rare (<1-4%)
HP:0003781	Excessive salivation	Very rare (<1-4%)
HP:0004372	Reduced consciousness/confusion	Very rare (<1-4%)
HP:0005268	Spontaneous abortion	Very rare (<1-4%)
HP:0005542	Prolonged whole-blood clotting time	Very rare (<1-4%)
HP:0012115	Hepatitis	Very rare (<1-4%)
HP:0012229	CSF pleocytosis	Very rare (<1-4%)
HP:0025013	Decerebrate rigidity	Very rare (<1-4%)
HP:0031691	Severe viral infection	Very rare (<1-4%)
HP:0040049	Macular edema	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	Rift valley fever
Mondo ID	MONDO:0017880
MeSH	D012295
Orphanet	319251
DOID	DOID:1328
ICD-10-CM	A92.4
ICD-11	854137188
NCIT	C128419
SNOMED CT	402917003
UMLS	C0035613
MedGen	20589
GARD	0021416
MedDRA	10039143
Is cancer (heuristic)	no

Also known as: RVF

Disease family

This is a subtype of viral hemorrhagic fever. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › viral infectious disease › viral hemorrhagic fever › Rift valley fever

Related subtypes (15): Dengue hemorrhagic fever, arenavirus hemorrhagic fever, Ebola hemorrhagic fever, Venezuelan equine encephalitis, Lujo hemorrhagic fever, Bolivian hemorrhagic fever, Venezuelan hemorrhagic fever, Brazilian hemorrhagic fever, Chapare hemorrhagic fever, hantavirus pulmonary syndrome, Kyasanur forest disease, Omsk hemorrhagic fever, hemorrhagic fever-renal syndrome, Marburg hemorrhagic fever, Crimean-Congo hemorrhagic fever

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 11.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE2	5
Not specified	3
PHASE1	2
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03609398	PHASE2	RECRUITING	Phase 2 Safety and Immunogenicity Study of Rift Valley Fever Vaccine
NCT06799234	PHASE2	ACTIVE_NOT_RECRUITING	Safety and Immunogenicity of a Candidate Rift Valley Fever Vaccine (RVF003)
NCT00415051	PHASE2	COMPLETED	Safety/Immunogenicity/Genetic Drift of MP-12 Rift Valley Fever Vaccine
NCT00584194	PHASE2	COMPLETED	Safety and Immunogenicity Study of Rift Valley Fever Vaccine
NCT00869713	PHASE2	COMPLETED	Safety and Immunogenicity Study of Rift Valley Fever Vaccine, Inactivated
NCT06925919	PHASE1	ACTIVE_NOT_RECRUITING	Study to Evaluate Safety, Tolerability and Pharmacokinetics of IDB-011
NCT04672824	PHASE1	COMPLETED	A Study to Assess the New Candidate Rift Valley Fever Virus Vaccine in Healthy Adults
NCT04754776	EARLY_PHASE1	COMPLETED	Safety and Immunogenicity of a Candidate RVFV Vaccine (RVF001)
NCT07358910	Not specified	RECRUITING	Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
NCT00287014	Not specified	COMPLETED	Rift Valley Fever in Kenya
NCT05139524	Not specified	UNKNOWN	RVF and Other Emerging Infectious Diseases in East and Central Africa

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
SODIUM CHLORIDE	4	1
RABIES VACCINE	3	1