Root caries
disease diseaseOn this page
Also known as cementum dental cariesdental caries of cementumdental caries of root surface
Summary
Root caries (MONDO:0006957) is a disease and 19 clinical trials. Top therapeutic interventions include water and silver diammine fluoride. A subtype of enamel caries — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 19
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | root caries |
| Mondo ID | MONDO:0006957 |
| EFO | EFO:1001163 |
| MeSH | D017213 |
| DOID | DOID:14089 |
| SNOMED CT | 30512007 |
| UMLS | C0162644 |
| MedGen | 57954 |
| Anatomy (UBERON) | UBERON:0001753 |
| Is cancer (heuristic) | no |
Also known as: cementum dental caries · dental caries of cementum · dental caries of root surface
Disease family
This is a subtype of enamel caries. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › tooth disorder › tooth hard tissue disease › dental caries › enamel caries › root caries
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 19.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 18 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02647203 | PHASE1/PHASE2 | COMPLETED | Non-invasive Treatment of Root Caries in Older Adults |
| NCT04822246 | Not specified | ACTIVE_NOT_RECRUITING | Root Caries Excavation with Air Water/powder Prophylaxis Device for ART Restorations |
| NCT05765058 | Not specified | NOT_YET_RECRUITING | The Efficacy of Tooth Mouse, SFD and NaF in Caries Activity in Root Caries. A Randomized Clinical Trial |
| NCT06131957 | Not specified | ACTIVE_NOT_RECRUITING | Root Caries Prevention Using Fluoride Varnish Fortified With SBGC |
| NCT06514885 | Not specified | RECRUITING | Silver Diamine Fluoride Application on Root Caries Fillings |
| NCT06619652 | Not specified | NOT_YET_RECRUITING | Egyptian Dentists Knowledge Regarding the Diagnosis and Management of Root Caries |
| NCT06723054 | Not specified | ACTIVE_NOT_RECRUITING | Prevention and Arrest of Root Caries Lesions with High Fluoride Concentration Mouthwash Versus Normal Fluoride Concentration Mouthwash in Elderly Patients |
| NCT07608497 | Not specified | NOT_YET_RECRUITING | Evaluation of Corrective Surgery Versus Dental Implants in Compromised Upper Molars |
| NCT03064217 | Not specified | COMPLETED | Intraoral Imaging at Clinical Crown Lengthening |
| NCT03185104 | Not specified | UNKNOWN | Silver Diamine Fluoride for Caries Prevention in Removable Partial Dentures Wearers |
| NCT03186352 | Not specified | UNKNOWN | Clinical Effect of Photoactivated Disinfection on Primary Root Carious Lesions After Partial Caries Removal |
| NCT03654820 | Not specified | UNKNOWN | Effectiveness on SDF Solution and PVP-I Combined NaF Varnish in Preventing Root Caries in Elders |
| NCT03722758 | Not specified | UNKNOWN | 36-Month Clinical Performance of Different Restorative Materials in the Treatment of Root Caries Lesions |
| NCT04370080 | Not specified | COMPLETED | Silver Diamine Fluoride Treatment of Active Root Caries Lesions in Older Adults: A Case Series |
| NCT04432415 | Not specified | SUSPENDED | Comparison of Silver Diamine Fluoride and Sodium Fluoride Varnish to Prevent and Arrest Root Caries in Older Adults |
| NCT05335239 | Not specified | COMPLETED | Domiciliary Professional Oral Care for Dependent Older Adults |
| NCT05509920 | Not specified | UNKNOWN | Assessment of Arresting Root Surface Caries After the Application of PRG Bioactive Varnish |
| NCT06709352 | Not specified | COMPLETED | Effect of Hypertensive Drugs on Root Caries Among Senior Patients in Cairo University |
| NCT06749275 | Not specified | COMPLETED | High Fluoride and Root Caries in Older Adults (NIT-RCL-UTALCA) |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| WATER | 4 | 2 |
| SILVER DIAMMINE FLUORIDE | 3 | 3 |
Related Atlas pages
- Drugs: Silver Diammine Fluoride