Root resorption
disease diseaseOn this page
Summary
Root resorption (MONDO:0001997) is a disease and 23 clinical trials. Top therapeutic interventions include cholecalciferol and fibrin. A subtype of tooth resorption — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 23
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | root resorption |
| Mondo ID | MONDO:0001997 |
| MeSH | D012391 |
| DOID | DOID:14550 |
| UMLS | C0035851 |
| MedGen | 11268 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of tooth resorption. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › tooth disorder › tooth hard tissue disease › tooth resorption › root resorption
Related subtypes (2): internal pathological resorption of tooth, external pathological resorption
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 23.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 21 |
| PHASE1/PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00423956 | PHASE1/PHASE2 | UNKNOWN | Repair of Orthodontically-induced Tooth Root Resorption by Ultrasound |
| NCT06847880 | PHASE1 | COMPLETED | The Potential Effect of the Local Administration of Vitamins C and E on Orthodontic Treatment: A Randomized Clinical Trial |
| NCT06199674 | Not specified | RECRUITING | Effects of PBM on Fixed-appliance Orthodontic Patients |
| NCT06567730 | Not specified | NOT_YET_RECRUITING | Comparison of Canine Retraction Using Ni-ti Closed-coil Springs Vs Elastomeric Power Chains During Orthodontic Treatment |
| NCT06926322 | Not specified | ENROLLING_BY_INVITATION | Evaluation of Different Medicaments in the Management of Necrotic Primary Molars by Lesion Sterilization and Tissue Repair |
| NCT06968325 | Not specified | ACTIVE_NOT_RECRUITING | AI-Designed Clear Aligners: A Randomized Clinical Trial |
| NCT07566676 | Not specified | RECRUITING | Maxillary Incisor Intrusion Using Utility Arch Assisted With Micro-osteoperforations |
| NCT02822040 | Not specified | COMPLETED | An Evaluation of Root Length Measurements Using Intraoral Scan and Panoramic Radiographs |
| NCT03613285 | Not specified | COMPLETED | A Comparative CT Evaluation of the Amount of Root Resorption in Self-ligating Versus Conventional Brackets |
| NCT03644537 | Not specified | UNKNOWN | Correlation Between Root Resorption and Dentin Sialoprotein Upon Application of Different Orthodontic Forces. |
| NCT03981367 | Not specified | UNKNOWN | Frequency of External Root Resorption in Mandibular Second Molars Associated With Mandibular Impacted Third Molars Using CBCT |
| NCT04291443 | Not specified | COMPLETED | Proteomics and Orthodontic Root Resorption |
| NCT04410679 | Not specified | COMPLETED | Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technque |
| NCT04823325 | Not specified | COMPLETED | Determining the Presence of RAP in Orthognathic Patients and Its Effect on Root Resorption by Biomarkers |
| NCT04825665 | Not specified | COMPLETED | The Effect of Two Different Types of Forces on Possible Root Resorption in Relation to Dentin Phosphoprotein Levels |
| NCT05077878 | Not specified | COMPLETED | Analysis of Dentine Sialophosphoprotein (DSPP) for Root Resorption |
| NCT05232318 | Not specified | UNKNOWN | Root Resorption Accompanied Clear Aligners and Fixed Orthodontic Appliance |
| NCT05606185 | Not specified | UNKNOWN | Amount of Root Resorption of Maxillary Anteriors After en Masse Versus Two Step Space Closure |
| NCT06198322 | Not specified | UNKNOWN | Effects of Platelet-rich Fibrin and Vitamin Dꝫ Injections on Root Resorption |
| NCT06520761 | Not specified | UNKNOWN | The Effect of Injectable PRF Vs LLL on Orthodontic Tooth Movement |
| NCT06709287 | Not specified | COMPLETED | Side Effects of Different Treatment Methods |
| NCT06912568 | Not specified | COMPLETED | Three-dimensional CBCT Analysis of Root Volume Changes Following Tooth-bone and Bone-borne Maxillary Expansion: A Pilot Study. |
| NCT07276984 | Not specified | COMPLETED | Photobiomodulation Effect on Vietnamese Orthodontic Patients |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CHOLECALCIFEROL | 4 | 1 |
| FIBRIN | 3 | 1 |
Related Atlas pages
- Drugs: Cholecalciferol, Fibrin