Rumination disorder
diseaseOn this page
Also known as ruminationrumination syndrome
Summary
Rumination disorder (MONDO:0001301) is a disease and 53 clinical trials. Top therapeutic interventions include baclofen. A subtype of eating disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 53
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | rumination disorder |
| Mondo ID | MONDO:0001301 |
| MeSH | D019959 |
| DOID | DOID:11507 |
| ICD-11 | 879747857 |
| NCIT | C92567 |
| SNOMED CT | 192014006 |
| UMLS | C0154575 |
| MedGen | 102311 |
| Is cancer (heuristic) | no |
Also known as: rumination · rumination syndrome
Disease family
This is a subtype of eating disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › eating disorder › rumination disorder
Related subtypes (5): pica disease, anorexia nervosa, bulimia nervosa, binge eating disorder, avoidant/restrictive food intake disorder
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 53.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 50 |
| PHASE3 | 2 |
| PHASE4 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT03113396 | PHASE4 | COMPLETED | Baclofen for Rumination |
| NCT01576302 | PHASE3 | COMPLETED | Comparison of Diaphragmatic Breathing and Muscle Relaxation for Rumination |
| NCT05975684 | PHASE3 | COMPLETED | Baclofen for Children With Rumination Syndrome |
| NCT04697966 | Not specified | RECRUITING | Mechanisms and Predictors of Change in App-Based Mindfulness Training for Adolescents |
| NCT05437705 | Not specified | RECRUITING | Decoding and Modulating Affective Brain States |
| NCT05590741 | Not specified | ACTIVE_NOT_RECRUITING | An Idiographic Examination of Treatment Mechanisms in Emotion Regulation Therapy |
| NCT05617495 | Not specified | RECRUITING | Mindfulness-Based fMRI Neurofeedback for Depression |
| NCT06532734 | Not specified | RECRUITING | Barrett’s Esophagitis in Anorexia Nervosa Binge/Purge Subtype |
| NCT06570694 | Not specified | NOT_YET_RECRUITING | RCT Protocol for ‘OverThinking’: A Mobile EMI for Reducing Experiential Avoidance |
| NCT06748976 | Not specified | RECRUITING | Modulation of Cortical Brain Activity During Attentional Control |
| NCT06778356 | Not specified | ENROLLING_BY_INVITATION | Effect of Environment on the Central and Peripheral Nervous System |
| NCT06828276 | Not specified | RECRUITING | Culturally Adapted i-CBT for Farsi/Dari Speaking Migrants |
| NCT06863909 | Not specified | ENROLLING_BY_INVITATION | Study on the Effectiveness of Journaling as an add-on to Cognitive Behavioral Therapy |
| NCT06937476 | Not specified | ACTIVE_NOT_RECRUITING | Neurobiological Mechanisms of Pathological Rumination and Effects of Aripiprazole |
| NCT06971354 | Not specified | RECRUITING | Treatment of Rumination |
| NCT07139197 | Not specified | NOT_YET_RECRUITING | The Effect of Cognitive Behavioral Therapy (CBT)-Based Psychoeducation on Cognitive Flexibility and Rumination in the Elderly |
| NCT07189715 | Not specified | RECRUITING | Optimization of Imagery Rescripting Research Using Generative Artificial Intelligence |
| NCT07478393 | Not specified | RECRUITING | Readiness and Progress in Emotion Regulation Therapy |
| NCT07503093 | Not specified | NOT_YET_RECRUITING | Pilot Study of Sensor-Informed Smartphone-based Mental Health Interventions for Mood in Early Psychosis |
| NCT07565714 | Not specified | RECRUITING | Optimization of Late Imagery Rescripting Research Using Generative Artificial Intelligence |
| NCT07609056 | Not specified | ACTIVE_NOT_RECRUITING | The Role of Rumination and Worry in Pain and Functional Limitation in Knee Osteoarthritis |
| NCT01185327 | Not specified | COMPLETED | Do Isreali Infants of Ethiopian Origin Mother Regurgitate More Than Other Infants? |
| NCT01983033 | Not specified | COMPLETED | Training Protocol ‘Drop it’. The Impact of a Training Protocol Focused on Coping With Negative Repetitive Thinking on Cognitive and Behavioural Functioning of People Suffering From GAD or Minor or Moderate Depressive Disorder or Depressive Disorder in Remission |
| NCT02214472 | Not specified | COMPLETED | Treatment of Rumination by Biofeedback - a Randomized Controlled Trial |
| NCT02253225 | Not specified | COMPLETED | Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) Study |
| NCT02331537 | Not specified | COMPLETED | Internet-based Exposure Therapy for Excessive Worry |
| NCT02402946 | Not specified | COMPLETED | Placebo-controlled, Randomized Trial of a Simplified Biofeedback Technique for the Treatment of Rumination |
| NCT03062696 | Not specified | COMPLETED | A Pilot Study of Cognitive-Behavioral Therapy for Rumination Disorder (CBT-RD) |
| NCT03113682 | Not specified | UNKNOWN | A Study of Cognitive-Behavioral Therapy for Rumination Disorder |
| NCT03322774 | Not specified | COMPLETED | Sleep To Reduce Incident Depression Effectively |
| NCT03487081 | Not specified | COMPLETED | Neural Predictors of Social Emotion Regulation Training |
| NCT03724305 | Not specified | COMPLETED | Reduce Emotional Symptoms of Insomnia With SleepTreatment |
| NCT03900416 | Not specified | COMPLETED | Adolescent Mindfulness Mobile App Study (RCT) |
| NCT03912636 | Not specified | COMPLETED | Role of Vagal Tone in Rumination Syndrome |
| NCT03915041 | Not specified | COMPLETED | Effects of tDCS Combined With VR on Anxious Ruminations in Healthy Subjects With a Vulnerability to Rumination |
| NCT03964285 | Not specified | COMPLETED | Repetitive Thinking in Fibromyalgia |
| NCT04167371 | Not specified | COMPLETED | Treament of Rumination |
| NCT04367636 | Not specified | TERMINATED | The Effects of Attention Training on Emotion Regulation and Stress Related Complaints During COVID-19 |
| NCT04560192 | Not specified | UNKNOWN | Mindfulness Based Emotion Regulation Therapy in the Treatment of Depressive Rumination |
| NCT04567888 | Not specified | COMPLETED | Testing a Digital Intervention for Adolescents |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| BACLOFEN | 4 | 2 |
Related Atlas pages
- Drugs: Baclofen