Schizoid personality disorder
disease diseaseOn this page
Summary
Schizoid personality disorder (MONDO:0001161) is a disease with 1 GWAS associations across 3 studies. A subtype of personality disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- GWAS associations: 1
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | schizoid personality disorder |
| Mondo ID | MONDO:0001161 |
| MeSH | D012557 |
| DOID | DOID:10936 |
| ICD-10-CM | F60.1 |
| ICD-11 | 1524611454 |
| NCIT | C92631 |
| SNOMED CT | 52954000 |
| UMLS | C0036339 |
| MedGen | 20662 |
| Is cancer (heuristic) | no |
Data availability: 1 GWAS association (3 studies).
Disease family
This is a subtype of personality disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › personality disorder › schizoid personality disorder
Related subtypes (9): schizotypal personality disorder, borderline personality disorder, dependent personality disorder, obsessive-compulsive personality disorder, paranoid personality disorder, antisocial personality disorder, avoidant personality disorder, narcissistic personality disorder, histrionic personality disorder
Genetics & variants
GWAS landscape
1 GWAS associations across 3 studies. Top hits map to 1 distinct genes (as reported by GWAS).
Top associations by p-value
| rsID | p-value | Gene | Risk allele | Odds ratio |
|---|---|---|---|---|
| rs537549704 | 7e-12 | LINC02782 | C | 3.12 |
Top studies (by case count)
| Study | Lead author | Year | Cases | Controls | Title |
|---|---|---|---|---|---|
| GCST90481792 | Verma A | 2024 | 1,772 | 448,169 | Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. |
| GCST90480757 | Verma A | 2024 | 385 | 121,112 | Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. |
| GCST90481791 | Verma A | 2024 | 385 | 121,112 | Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. |
Variant details and genetic-evidence tiers
Tier distribution (top 50 variants)
| Tier | Variants |
|---|---|
| Tier 1: coding | 0 |
| Tier 2: splice/UTR | 0 |
| Tier 3: regulatory | 0 |
| Tier 4: intronic/intergenic | 1 |
MAF distribution
| Bucket | Variants |
|---|---|
| common (>=0.05) | 0 |
| low_freq (0.01-0.05) | 0 |
| rare (<0.01) | 1 |
| unknown | 0 |
Functional consequences
| Consequence | Count |
|---|---|
| intron_variant | 1 |
Top variants
| rsID | Chr | Pos | Alleles | MAF | Consequence | Gene | p-value | Tier |
|---|---|---|---|---|---|---|---|---|
| rs537549704 | 1 | 5086791 | C>T | 0 | intron_variant | LINC02782 | 7e-12 | Tier 4: intronic/intergenic |
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.