Schöpf-Schulz-Passarge syndrome

Summary

Schöpf-Schulz-Passarge syndrome (MONDO:0009145) is a disease with 1 cohort gene.

At a glance

• Prevalence: <1 / 1 000 000 (Worldwide) [Orphanet-validated]
• Cohort genes: 1
• ClinVar variants: 165
• Phenotypes (HPO): 12

Clinical features

Epidemiology

Prevalence records

2 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Cases/families		25	Worldwide	Validated
Point prevalence	<1 / 1 000 000		Worldwide	Validated

Signs & symptoms

Clinical features (HPO)

12 HPO clinical features (Orphanet curated; top 12 by frequency):

HPO ID	Term	Frequency
HP:0000968	Ectodermal dysplasia	Very frequent (80-99%)
HP:0000982	Palmoplantar keratoderma	Very frequent (80-99%)
HP:0007380	Facial telangiectasia	Very frequent (80-99%)
HP:0008070	Sparse hair	Very frequent (80-99%)
HP:0000668	Hypodontia	Frequent (30-79%)
HP:0001596	Alopecia	Frequent (30-79%)
HP:0006323	Premature loss of primary teeth	Frequent (30-79%)
HP:0100840	Aplasia/Hypoplasia of the eyebrow	Frequent (30-79%)
HP:0000320	Bird-like facies	Occasional (5-29%)
HP:0002671	Basal cell carcinoma	Occasional (5-29%)
HP:0002860	Squamous cell carcinoma	Occasional (5-29%)
HP:0100615	Ovarian neoplasm	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	Schöpf-Schulz-Passarge syndrome
Mondo ID	MONDO:0009145
MeSH	C565607
OMIM	224750
Orphanet	50944
DOID	DOID:0111647
SNOMED CT	700062000
UMLS	C1857069
MedGen	347366
GARD	0016649
Is cancer (heuristic)	no

Also known as: eccrine tumors-ectodermal dysplasia · eccrine tumours with ectodermal dysplasia · keratosis palmoplantaris-cystic eyelids-hypodontia-hypotrichosis syndrome · palmoplantar hyperkeratosis-cystic eyelids-hypodontia-hypotrichosis syndrome · palmoplantar keratoderma-cystic eyelids-hypodontia-hypotrichosis syndrome · SCHOPF-Schulz-Passarge syndrome · SSPS

Data availability: 165 ClinVar variants · 1 GenCC gene-disease record.

Disease family

Classification path: disease › human disease › disease by etiologic mechanism › disease of genetic or genomic mechanism › hereditary disease › autosomal genetic disease › autosomal recessive disease › Schöpf-Schulz-Passarge syndrome

Related subtypes (218): immunodeficiency-centromeric instability-facial anomalies syndrome, hypercalcemia, infantile, Ochoa syndrome, autosomal recessive Ehlers-Danlos syndrome, vascular type, hydrolethalus syndrome, 3-M syndrome, isolated hyperchlorhidrosis, dacryocystitis-osteopoikilosis syndrome, Hutchinson-Gilford progeria syndrome, achalasia microcephaly syndrome, acrorenal syndrome, autosomal recessive, beta-ketothiolase deficiency, autosomal recessive Alport syndrome, Alstrom syndrome, microphthalmia with limb anomalies, camptodactyly-arthropathy-coxa vara-pericarditis syndrome, Behr syndrome, bifid nose, autosomal recessive, Bloom syndrome, Bowen-Conradi syndrome, camptodactyly with fibrous tissue hyperplasia and skeletal dysplasia, heart defects-limb shortening syndrome, autosomal recessive palmoplantar keratoderma and congenital alopecia, COFS syndrome, craniometaphyseal dysplasia, autosomal recessive, Fraser syndrome, cystic fibrosis, polycystic lipomembranous osteodysplasia with sclerosing leukoencephaly, persistent hyperplastic primary vitreous, autosomal recessive, Donnai-Barrow syndrome, cleft lip/palate-ectodermal dysplasia syndrome, Ellis-van Creveld syndrome, Wolcott-Rallison syndrome, autosomal recessive faciodigitogenital syndrome, acromesomelic dysplasia 2B, brittle cornea syndrome, triple-A syndrome, autosomal recessive humeroradial synostosis, multinucleated neurons-anhydramnios-renal dysplasia-cerebellar hypoplasia-hydranencephaly syndrome, hydrocephalus, nonsyndromic, autosomal recessive 1, autosomal recessive hydrocephalus due to congenital stenosis of aqueduct of Sylvius, hypertelorism, microtia, facial clefting syndrome, hypoparathyroidism-retardation-dysmorphism syndrome, Vici syndrome, Johanson-Blizzard syndrome, autosomal recessive Kenny-Caffey syndrome, Papillon-Lefevre disease, Haim-Munk syndrome, Laurence-Moon syndrome, Donohue syndrome, lipase deficiency, combined, autosomal recessive familial Mediterranean fever, thiamine-responsive megaloblastic anemia syndrome, cartilage-hair hypoplasia, Nijmegen breakage syndrome, pseudo-TORCH syndrome, Galloway-Mowat syndrome, mulibrey nanism, myotonia congenita, autosomal recessive, Schwartz-Jampel syndrome, proteosome-associated autoinflammatory syndrome, Netherton syndrome, Niemann-Pick disease type A, oculodentodigital dysplasia, autosomal recessive, odonto-onycho-dermal dysplasia, autosomal recessive omodysplasia, osteoporosis-pseudoglioma syndrome, Shwachman-Diamond syndrome, phenylketonuria, Bjornstad syndrome, Laron syndrome, autosomal recessive polycystic kidney disease, autosomal recessive inherited pseudoxanthoma elasticum, autosomal recessive multiple pterygium syndrome, rapadilino syndrome, short-rib thoracic dysplasia 9 with or without polydactyly, autosomal recessive Robinow syndrome, Sjogren-Larsson syndrome, scapuloperoneal spinal muscular atrophy, autosomal recessive, spondyloepiphyseal dysplasia tarda, autosomal recessive, inherited threoninemia, Pendred syndrome, autosomal recessive spondylocostal dysostosis, Werner syndrome, ABCD syndrome, Naxos disease, autosomal recessive amelia, human HOXA1 syndromes, sickle cell disease, autosomal recessive proximal renal tubular acidosis, hyper-IgM syndrome type 2, temtamy preaxial brachydactyly syndrome, TH-deficient dopa-responsive dystonia, craniosynostosis syndrome, autosomal recessive, Niemann-Pick disease type B, skin fragility-woolly hair-palmoplantar keratoderma syndrome, CoQ-responsive OXPHOS deficiency, familial adenomatous polyposis 2, Pierson syndrome, palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome, cardiomyopathy-hypotonia-lactic acidosis syndrome, PHARC syndrome, Kahrizi syndrome, cutis laxa with severe pulmonary, gastrointestinal and urinary anomalies, congenital prothrombin deficiency, immunodeficiency 31B, dyskeratosis congenita, autosomal recessive 2, dyskeratosis congenita, autosomal recessive 3, Nestor-Guillermo progeria syndrome, leukoencephalopathy with calcifications and cysts, mitochondrial pyruvate carrier deficiency, branched-chain keto acid dehydrogenase kinase deficiency, dyskeratosis congenita, autosomal recessive 5, hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome, alacrima, achalasia, and intellectual disability syndrome, hyperlipoproteinemia, type 1D, microcephaly and chorioretinopathy 2, congenital stationary night blindness 1G, combined oxidative phosphorylation deficiency 29, hypermanganesemia with dystonia 2, growth retardation, intellectual developmental disorder, hypotonia, and hepatopathy, gnb5-related intellectual disability-cardiac arrhythmia syndrome, autosomal recessive spastic paraplegia type 78, autosomal recessive limb-girdle muscular dystrophy, Bardet-Biedl syndrome, autosomal recessive cerebellar ataxia, neuronopathy, distal hereditary motor, autosomal recessive, UV-sensitive syndrome, Ehlers-Danlos syndrome, kyphoscoliotic type 1, Cockayne syndrome, hyperphenylalaninemia due to tetrahydrobiopterin deficiency, leukoencephalopathy-palmoplantar keratoderma syndrome, autosomal recessive hypohidrotic ectodermal dysplasia, Warburg micro syndrome, autosomal recessive primary microcephaly, autosomal recessive progressive external ophthalmoplegia, Meier-Gorlin syndrome, autosomal recessive sideroblastic anemia, autosomal recessive intermediate Charcot-Marie-Tooth disease, Perrault syndrome, autosomal recessive hypophosphatemic rickets, de Barsy syndrome, leukocyte adhesion deficiency, Senior-Loken syndrome, autosomal recessive spastic ataxia, childhood-onset autosomal recessive myopathy with external ophthalmoplegia, autosomal recessive cerebral atrophy, GM3 synthase deficiency, autosomal recessive distal renal tubular acidosis, pigmentation defects-palmoplantar keratoderma-skin carcinoma syndrome, autosomal recessive brachyolmia, Aicardi-Goutieres syndrome, homocystinuria without methylmalonic aciduria, Niemann-Pick disease type C, nephronophthisis, autosomal recessive osteopetrosis, peroxisome biogenesis disorder, congenital non-bullous ichthyosiform erythroderma, Seckel syndrome, Usher syndrome, autosomal recessive cutis laxa type 1, autosomal recessive cutis laxa type 2, hearing loss, autosomal recessive, microcephaly, growth restriction, and increased sister chromatid exchange 2, encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 1, congenital vertebral-cardiac-renal anomalies syndrome, hair defect with photosensitivity and intellectual disability syndrome, autosomal recessive severe congenital neutropenia, severe combined immunodeficiency due to CARMIL2 deficiency, extraoral halitosis due to methanethiol oxidase deficiency, neurodevelopmental disorder with microcephaly, impaired language, epilepsy, and gait abnormalities, mitochondrial complex 2 deficiency, nuclear type 3, mitochondrial complex 2 deficiency, nuclear type 4, mismatch repair cancer syndrome, spondyloepimetaphyseal dysplasia with joint laxity, type 3, Kilquist syndrome, Duane anomaly-myopathy-scoliosis syndrome, autosomal recessive axonal charcot-marie-tooth disease due to copper metabolism defect, immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections-lymphopenia syndrome, optic atrophy-ataxia-peripheral neuropathy-global developmental delay syndrome, congenital myopathy with reduced type 2 muscle fibers, NAD(P)HX dehydratase deficiency, autosomal recessive ocular albinism, ichthyosis linearis circumflexa, eosinophil peroxidase deficiency, hyperphenylalaninemia due to DNAJC12 deficiency, autosomal recessive epidermolytic ichthyosis, Ehlers-Danlos syndrome, classic-like, 2, joint laxity, short stature, and myopia, HELIX syndrome, auditory neuropathy-optic atrophy syndrome, glycosylphosphatidylinositol biosynthesis defect 15, neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures, SCN4A-related myopathy, autosomal recessive, Uner Tan Syndrome, nephropathic cystinosis, Imerslund-Grasbeck syndrome type 1, Imerslund-Grasbeck syndrome type 2, permanent neonatal diabetes mellitus 1, growth hormone insensitivity with immune dysregulation 1, autosomal recessive, Rajab interstitial lung disease with brain calcifications 1, Roberts-SC phocomelia syndrome, neurodevelopmental disorder with microcephaly, impaired language, and gait abnormalities, RPE65-related recessive retinopathy, GUCY2D-related recessive retinopathy, autosomal recessive titinopathy, intellectual disability, autosomal recessive, ALPL-related autosomal recessive hypophosphatasia, spastic paraplegia 18b, autosomal recessive, CEP164-related ciliopathy, RP1-related recessive retinopathy, pseudohypoaldosteronism, type IB2, autosomal recessive, pseudohypoaldosteronism, type IB3, autosomal recessive, spastic paraplegia 30B, autosomal recessive, cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 1, brain small vessel disease 2B, autosomal recessive, IMPG1-related recessive retinopathy, PROM1-related recessive retinopathy

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

ClinVar germline variants

165 retrieved; paginated sample, class counts are floors:

66 uncertain significance, 25 conflicting classifications of pathogenicity, 24 likely benign, 23 pathogenic/likely pathogenic, 17 likely pathogenic, 4 benign/likely benign, 3 pathogenic, 3 benign

ClinVar	Variant (HGVS)	Gene	Classification	Review
1072161	NM_025216.3(WNT10A):c.990_1003dup (p.Asp335fs)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1074378	NM_025216.3(WNT10A):c.832C>T (p.Gln278Ter)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1466056	NM_025216.3(WNT10A):c.1A>T (p.Met1Leu)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1484123	NM_025216.3(WNT10A):c.322T>C (p.Ser108Pro)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1904869	NM_025216.3(WNT10A):c.3G>A (p.Met1Ile)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1916936	NM_025216.3(WNT10A):c.37C>T (p.Arg13Ter)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
2026165	NM_025216.3(WNT10A):c.68G>A (p.Trp23Ter)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
265292	NM_025216.3(WNT10A):c.391G>A (p.Ala131Thr)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
265293	NM_025216.3(WNT10A):c.742C>T (p.Arg248Ter)	WNT10A	Pathogenic	criteria provided, multiple submitters, no conflicts
265294	NM_025216.3(WNT10A):c.803C>G (p.Ser268Ter)	WNT10A	Pathogenic	criteria provided, multiple submitters, no conflicts
3585674	NM_025216.3(WNT10A):c.1226_1230del (p.Ile409fs)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
3753111	NM_025216.3(WNT10A):c.812del (p.Cys271fs)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
378862	NM_025216.3(WNT10A):c.1168G>T (p.Glu390Ter)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
432003	NM_025216.3(WNT10A):c.1084T>C (p.Cys362Arg)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
4461	NM_025216.3(WNT10A):c.321C>A (p.Cys107Ter)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
4463	NM_025216.3(WNT10A):c.383G>A (p.Arg128Gln)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
464181	NM_025216.3(WNT10A):c.382C>T (p.Arg128Ter)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
464182	NM_025216.3(WNT10A):c.433G>A (p.Val145Met)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
4787065	NM_025216.3(WNT10A):c.289C>T (p.Gln97Ter)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
532827	NM_025216.3(WNT10A):c.310C>T (p.Arg104Cys)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
532829	NM_025216.3(WNT10A):c.910A>C (p.Asn304His)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
559394	NM_025216.3(WNT10A):c.949del (p.Ala317fs)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
639357	NM_025216.3(WNT10A):c.694del (p.Arg232fs)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
68843	NM_025216.3(WNT10A):c.283G>A (p.Glu95Lys)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
841749	NM_025216.3(WNT10A):c.814C>T (p.Gln272Ter)	WNT10A	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
936775	NM_025216.3(WNT10A):c.376+1G>A	WNT10A	Pathogenic	criteria provided, multiple submitters, no conflicts
1950565	NM_025216.3(WNT10A):c.113+1G>A	WNT10A	Likely pathogenic	criteria provided, multiple submitters, no conflicts
2577028	NM_025216.3(WNT10A):c.889G>A (p.Ala297Thr)	WNT10A	Likely pathogenic	criteria provided, multiple submitters, no conflicts
3039373	NM_025216.3(WNT10A):c.532_537delinsA (p.Gln178fs)	WNT10A	Likely pathogenic	criteria provided, single submitter
3585673	NM_025216.3(WNT10A):c.376G>A (p.Gly126Ser)	WNT10A	Likely pathogenic	criteria provided, single submitter

Genes & proteins

Mendelian disease overlap and somatic drivers

GenCC: 10 · Orphanet: 4 · OMIM-shared: 0 · Dual-evidence (GWAS+Mendelian): 0

GenCC gene–disease validity (cohort genes)

the Disease column is the GenCC-asserted condition — a cohort gene’s strongest validity may be for a related predisposition syndrome.

Gene	Classification	Inheritance	Disease	Records
WNT10A	Supportive	Autosomal dominant	Schöpf-Schulz-Passarge syndrome	10

Orphanet rare-disease linkage (cohort genes)

Gene	Orphanet ID	Rare disease
WNT10A	Orphanet:248	Autosomal recessive hypohidrotic ectodermal dysplasia
WNT10A	Orphanet:2721	Odonto-onycho-dermal dysplasia
WNT10A	Orphanet:50944	Schöpf-Schulz-Passarge syndrome
WNT10A	Orphanet:99798	Oligodontia

Cohort genes → proteins

1 cohort genes, 1 distinct canonical proteins.

Evidence partition

Subset	Genes
multi_evidence	1

Cohort genes (full)

Symbol	HGNC	Ensembl	UniProt	Name	Evidence
WNT10A	HGNC:13829	ENSG00000135925	Q9GZT5	Protein Wnt-10a	gencc,clinvar

Cohort function summary

Lead sentence per gene, UniProt-curated.

Symbol	Protein name	Function (lead sentence)
WNT10A	Protein Wnt-10a	Ligand for members of the frizzled family of seven transmembrane receptors.

Protein-family classification

Druggable: 0 · Difficult: 0 · Unknown: 1 · Druggable fraction: 0.0

Family distribution

Cohort families vs a genome-wide background (hypergeometric, BH-FDR; fold = observed/expected). Counts kept; sorted by enrichment, so the catch-all Other/Unknown bucket no longer leads.

Family	Genes	Fold	FDR
Other/Unknown	1	1.8×	0.558

Per-gene assignment

Symbol	Family	Druggable?	EC	InterPro (top 3)
WNT10A	Other/Unknown	no		Wnt, Wnt10, Wnt_CS

Expression context

Cohort genes with no expression data: 0.

1 cohort gene are a single-cell marker in ≥1 SCXA experiment.

Breadth distribution (Bgee present_calls)

Bucket	Genes
narrow (1-5 tissues)	0
moderate (6-20)	0
broad (>20)	1
unknown	0

Top tissues across cohort

Tissue	Cohort genes
bone marrow cell	1
lower esophagus mucosa	1
primordial germ cell in gonad	1

Per-gene tissue summary (top 30)

Symbol	Bgee breadth	FANTOM5 breadth	SCXA	Top tissues
WNT10A	151	broad	marker	primordial germ cell in gonad, lower esophagus mucosa, bone marrow cell

Protein interactions among cohort

Intra-cohort edges: 0.

Hub genes (top 10 by interactor count)

Symbol	Interactor count
WNT10A	1,092

Structural data

PDB: 0 · AlphaFold-only: 1 · No structure: 0

AlphaFold-only cohort genes (top 30 by pLDDT)

Symbol	UniProt	pLDDT
WNT10A	Q9GZT5	82.36

Function

Pathway analysis

Distinct Reactome pathways touched by cohort: 2. Enrichment computed across 1 evidence-associated genes (1 with Reactome annotation).

Pathways by enrichment

Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 1 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.

Pathway	Cohort genes	Fold	FDR	Sample cohort genes
WNT ligand biogenesis and trafficking	1	423.0×	0.005	WNT10A
Class B/2 (Secretin family receptors)	1	190.3×	0.005	WNT10A

GO biological processes by enrichment

Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 1 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.

GO term	Cohort genes	Fold	FDR	Sample cohort genes
epidermis morphogenesis	1	2808.7×	0.002	WNT10A
regulation of odontogenesis of dentin-containing tooth	1	2407.4×	0.002	WNT10A
tongue development	1	2106.5×	0.002	WNT10A
sebaceous gland development	1	2106.5×	0.002	WNT10A
neural crest cell differentiation	1	1532.0×	0.002	WNT10A
odontogenesis	1	526.6×	0.004	WNT10A
hair follicle morphogenesis	1	495.6×	0.004	WNT10A
skin development	1	443.5×	0.004	WNT10A
hair follicle development	1	383.0×	0.004	WNT10A
cell fate commitment	1	295.6×	0.005	WNT10A
cellular response to transforming growth factor beta stimulus	1	276.3×	0.005	WNT10A
canonical Wnt signaling pathway	1	153.2×	0.008	WNT10A
neuron differentiation	1	100.3×	0.011	WNT10A
positive regulation of gene expression	1	38.7×	0.026	WNT10A

Therapeutics

Drug target analysis

Approved (phase 4): 0 · Phase ≥3: 0 · Phased (≥1): 0 · Undrugged: 1

Druggability breadth: 0 of 1 evidence-associated genes (0%) have a ChEMBL target (buckets above are over the deeply-mined display cohort).

Top cohort targets by molecule count

Symbol	Molecules	Max phase
WNT10A	0	0

Bioactivity and enzyme data

Enzyme cohort genes (≥1 EC): 0.

Pharmacogenomics

Cohort genes with a PharmGKB record: 1; with CPIC/DPWG dosing guidelines: 0.

No cohort gene has a CPIC/DPWG genotype-guided dosing guideline (PharmGKB).

Chemical tractability of cohort targets

0 approved/phased compounds have measured bioactivity against a cohort gene (and aren’t yet in disease-level trials). This is a research / tractability signal, NOT a therapeutic recommendation — a bioactivity row often reflects off-target or screening binding (e.g. promiscuous kinase inhibitors against a cohort kinase), implying no disease mechanism.

Druggability pyramid

Cohort genes binned by druggability tier (high → low):

Tier	Definition	Genes	Symbols
A	Approved (phase 4 drug)	0
B	Phased (≥1) drug, not yet approved	0
C	Druggable family + PDB, no drug	0
D	Druggable family + AlphaFold only, no drug	0
E	Difficult family or no structure, no drug	1	WNT10A

Undrugged target profiles

1 cohort genes are undrugged. Ranked by ‘starting-point quality’ (assay depth + drugged-partner adjacency).

Symbol	ChEMBL assays	Drugged partners (top 3)
WNT10A	0	—

Clinical trials & evidence

Clinical trials

Clinical trials: 0.