Sciatica

Summary

Sciatica (MONDO:0024333) is a disease and 103 clinical trials. Top therapeutic interventions include fluoxetine, methylprednisolone, and benztropine. A subtype of sciatic neuropathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 103

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	sciatica
Mondo ID	MONDO:0024333
MeSH	D012585
ICD-10-CM	M54.3
ICD-11	2056651014
SNOMED CT	23056005
UMLS	C0036396
MedGen	19893
Is cancer (heuristic)	no

Also known as: bilateral sciatica · bilateral sciaticas · neuralgia, sciatic · neuralgias, sciatic · sciatic neuralgia · sciatic Neuralgias · sciatica, bilateral

Disease family

This is a subtype of sciatic neuropathy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › peripheral nervous system disorder › peripheral neuropathy › mononeuropathy › sciatic neuropathy › sciatica

Related subtypes (1): lesion of sciatic nerve

Subtypes (1): piriformis syndrome

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 5 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Dexamethasone	Phase 3 (in late-stage trials)
Lacosamide	Phase 3 (in late-stage trials)
Meperidine	Phase 3 (in late-stage trials)
Prednisolone Acetate	Phase 3 (in late-stage trials)
Prednisone	Phase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Adalimumab, Benztropine, Betamethasone, Desipramine, Fasinumab, Fluoxetine, Sodium Chloride, Topiramate.

Clinical trials & evidence

Clinical trials

Clinical trials: 103.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	66
PHASE2	12
PHASE4	8
PHASE3	7
PHASE1	6
PHASE1/PHASE2	3
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06157177	PHASE4	RECRUITING	Efficacy of M640 in Acute Lumbosacral Musculoskeletal Conditions.
NCT07494136	PHASE4	NOT_YET_RECRUITING	Dose Dependent Steroid Injections
NCT00749996	PHASE4	COMPLETED	Herniectomy Versus Herniectomy With a Spinal Stabilization System for the Treatment of Complex Disc Disease
NCT01816334	PHASE4	COMPLETED	Safety and Efficacy of Nonsteroidal Antiinflammatory (NSAI)Drug and Glucocorticoids in Acute Sciatica
NCT01934868	PHASE4	COMPLETED	Prolotherapy Versus Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg
NCT02504996	PHASE4	UNKNOWN	IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia
NCT02777320	PHASE4	UNKNOWN	Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Department
NCT03347929	PHASE4	COMPLETED	NSAIDs in Sciatica NSAIDS IN SCIATICA
NCT00163553	PHASE3	UNKNOWN	Neuraxial Pethidine After Lumbar Surgery Trial
NCT00317447	PHASE3	COMPLETED	The Efficacy of Oral Steroids in the Treatment of Acute Sciatica
NCT00364546	PHASE3	COMPLETED	A Study to Evaluate 90-Day Safety of Tapentadol(CG5503) Immediate Release (IR) or Oxycodone Immediate Release in Patients With Chronic Pain
NCT00942227	PHASE3	COMPLETED	The Value of Traction in Treatment of Lumbar Radiculopathy
NCT02618278	PHASE3	COMPLETED	Physiotherapy for Sciatica; Is Earlier Better?
NCT05000658	PHASE3	COMPLETED	Efficacy of Soluble Dexamethasone in Refractory Sciatica
NCT05626140	PHASE3	COMPLETED	COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA
NCT00009672	PHASE2	COMPLETED	Pain Treatment for Sciatica
NCT00011804	PHASE2	COMPLETED	Topiramate in the Treatment of Sciatica
NCT00018200	PHASE2	COMPLETED	Effect of Antidepressants on Back Pain
NCT00044109	PHASE2	COMPLETED	Magnets in the Treatment of Sciatica
NCT00107055	PHASE2	UNKNOWN	Study of REN-1654 in Patients With Sciatica Pain
NCT00364572	PHASE1/PHASE2	COMPLETED	Efficacy of Epidural Etanercept in the Treatment of Sciatica
NCT00415220	PHASE2	COMPLETED	Manipulation or Microdiscectomy For Sciatica? A Prospective Randomized Controlled Trial.
NCT00470509	PHASE2	COMPLETED	Adalimumab in Severe and Acute Sciatica
NCT00668434	PHASE2	COMPLETED	Effectiveness of Oral Prednisone in Improving Physical Functioning and Decreasing Pain in People With Sciatica
NCT00991172	PHASE2	COMPLETED	A Study to Evaluate the Safety and Efficacy of Subcutaneously Administered REGN475(SAR164877) in Patients With Sciatic Pain
NCT01240876	PHASE1/PHASE2	COMPLETED	Study to Evaluate the Safety and Efficacy of Placulumab (CEP-37247) Administered by the Transforaminal Epidural Route for the Treatment of Patients With Lumbosacral Radicular Pain Associated With Disk Herniation
NCT01873404	PHASE2	COMPLETED	BG00010 (Neublastin) Phase 2 Multiple Dose Adaptive Design in Participants With Painful Lumbar Radiculopathy
NCT01917825	PHASE2	COMPLETED	A Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of MDT-15 in Subjects With Lumbosacral Radiculopathy
NCT03240783	PHASE2	UNKNOWN	A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain
NCT04145310	PHASE1/PHASE2	COMPLETED	BOL-DP-o-04 in Patients With Low Back Pain and Sciatica
NCT07264270	PHASE1	RECRUITING	Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy
NCT00573807	PHASE1	UNKNOWN	Energy Specific Far Infrared Radiation Treatment for Sciatica
NCT00961766	PHASE1	COMPLETED	Evaluate the Safety, Tolerability and Pharmacokinetics of BG00010 (Neublastin) Administered to Sciatica Participants
NCT01405833	PHASE1	COMPLETED	Study of the Safety, Tolerability, Pharmacokinetics and Safety of BG00010 (Neublastin) in Subjects With Sciatica.
NCT02644421	PHASE1	COMPLETED	Clinical Trial to Evaluate the Safety and Analgesic Efficacy of VVZ-149 in Lumbar Radiculopathy (Sciatica)
NCT02951377	PHASE1	TERMINATED	Mechanical Diagnosis and Treatment and/or Steroid Injections for Lumbar Radiculopathy
NCT02753101	EARLY_PHASE1	COMPLETED	[18F]FTC-146 PET/MRI in Healthy Volunteers and in CRPS and Sciatica
NCT03879447	Not specified	ACTIVE_NOT_RECRUITING	Effectiveness and Safety of Korean Medicine for Low Back Pain or Sciatica Due to Lumbar Stenosis/Spondylolisthesis
NCT03924791	Not specified	RECRUITING	Transforaminal Epidural Injection in Acute Sciatica
NCT06536829	Not specified	RECRUITING	Effects of Myofacial Release Technique and Sciatic Nerve Slider Technique in Sciatica

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
FLUOXETINE	4	3
METHYLPREDNISOLONE	4	2
BENZTROPINE	4	1
CODEINE PHOSPHATE	4	1
DESIPRAMINE	4	1
DEXAMETHASONE PHOSPHORIC ACID	4	1
DICLOFENAC SODIUM	4	1
IBUPROFEN	4	1
KETOPROFEN	4	1
MEPERIDINE	4	1
METHYLPREDNISOLONE ACETATE	4	1
NAPROXEN	4	1
NORTRIPTYLINE	4	1
SODIUM CHLORIDE	4	1
TRIAMCINOLONE	4	1
FASINUMAB	3	1
ROSE OIL	3	1
ARTEMIN	2	3
PLACULUMAB	2	1
CHEMBL5592090	0	2
CHEMBL1618254	0	1
CHEMBL4747028	0	1
CHEMBL116590	0	1
ALMOND OIL	-1	1