Scorpion envenomation

Summary

Scorpion envenomation (MONDO:0018755) is a disease and 3 clinical trials. Top therapeutic interventions include prazosin and dexamethasone. A subtype of poisoning — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide) [Orphanet-validated]
• Phenotypes (HPO): 58
• Clinical trials: 3

Clinical features

Signs & symptoms

Clinical features (HPO)

58 HPO clinical features (Orphanet curated; top 50 by frequency):

HPO ID	Term	Frequency
HP:0000969	Edema	Very frequent (80-99%)
HP:0010783	Erythema	Very frequent (80-99%)
HP:0012531	Pain	Very frequent (80-99%)
HP:0001649	Tachycardia	Very frequent (80-99%)
HP:0002027	Abdominal pain	Frequent (30-79%)
HP:0031546	Cardiac conduction abnormality	Frequent (30-79%)
HP:0000616	Miosis	Frequent (30-79%)
HP:0003401	Paresthesia	Frequent (30-79%)
HP:0000711	Restlessness	Frequent (30-79%)
HP:0002013	Vomiting	Frequent (30-79%)
HP:0031416	Abnormal nasal mucus secretion	Occasional (5-29%)
HP:0004360	Abnormality of acid-base homeostasis	Occasional (5-29%)
HP:0001735	Acute pancreatitis	Occasional (5-29%)
HP:0011675	Arrhythmia	Occasional (5-29%)
HP:0030149	Cardiogenic shock	Occasional (5-29%)
HP:0025143	Chills	Occasional (5-29%)
HP:0001635	Congestive heart failure	Occasional (5-29%)
HP:0002014	Diarrhea	Occasional (5-29%)
HP:0031956	Elevated circulating aspartate aminotransferase concentration	Occasional (5-29%)
HP:0003781	Excessive salivation	Occasional (5-29%)
HP:0003076	Glycosuria	Occasional (5-29%)
HP:0003074	Hyperglycemia	Occasional (5-29%)
HP:0000975	Hyperhidrosis	Occasional (5-29%)
HP:0000822	Hypertension	Occasional (5-29%)
HP:0002900	Hypokalemia	Occasional (5-29%)
HP:0031185	Increased circulating NT-proBNP concentration	Occasional (5-29%)
HP:0032232	Increased circulating creatine kinase MB isoform	Occasional (5-29%)
HP:0025435	Increased circulating lactate dehydrogenase concentration	Occasional (5-29%)
HP:0410173	Increased circulating troponin I concentration	Occasional (5-29%)
HP:0005967	Mixed respiratory and metabolic acidosis	Occasional (5-29%)
HP:0011499	Mydriasis	Occasional (5-29%)
HP:0200023	Priapism	Occasional (5-29%)
HP:0025072	Prominent U wave	Occasional (5-29%)
HP:0100598	Pulmonary edema	Occasional (5-29%)
HP:0000979	Purpura	Occasional (5-29%)
HP:0001950	Respiratory alkalosis	Occasional (5-29%)
HP:0012250	ST segment depression	Occasional (5-29%)
HP:0010872	T-wave inversion	Occasional (5-29%)
HP:0002789	Tachypnea	Occasional (5-29%)
HP:0001337	Tremor	Occasional (5-29%)
HP:0012547	Abnormal involuntary eye movements	Very rare (<1-4%)
HP:0001919	Acute kidney injury	Very rare (<1-4%)
HP:0001251	Ataxia	Very rare (<1-4%)
HP:0000622	Blurred vision	Very rare (<1-4%)
HP:0011710	Bundle branch block	Very rare (<1-4%)
HP:0001260	Dysarthria	Very rare (<1-4%)
HP:0100660	Dyskinesia	Very rare (<1-4%)
HP:0001945	Fever	Very rare (<1-4%)
HP:0010828	Hemifacial spasm	Very rare (<1-4%)
HP:0002487	Hyperkinetic movements	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	scorpion envenomation
Mondo ID	MONDO:0018755
Orphanet	466677
ICD-10-CM	T63.2
SNOMED CT	217670007
GARD	0021939
Is cancer (heuristic)	no

Also known as: poisoning caused by scorpion venom · poisoning due to scorpion venom · toxic effect of venom of scorpion

Disease family

This is a subtype of poisoning. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › poisoning › scorpion envenomation

Related subtypes (58): toxic oil syndrome, infantile mercury poisoning, ketamine-induced biliary dilatation, manganese poisoning, cyanide-induced parkinsonism, colchicine poisoning, methanol poisoning, ethylene glycol poisoning, paraquat poisoning, lead poisoning, mercury poisoning, acute opioid poisoning, acute tricyclic antidepressant poisoning, acute poisoning by drugs with membrane-stabilizing effect, snakebite envenomation, paracetamol poisoning, cyanide poisoning, argyria, acute ackee fruit intoxication, cocaine intoxication, systemic monochloroacetate poisoning, water intoxication, cassavism, formaldehyde poisoning, heavy metal poisoning, abacavir toxicity, allopurinol toxicity, codeine toxicity, efavirenz toxicity, flucloxacilline toxicity, isoniazid toxicity, raltegravir toxicity, voriconazole toxicity, curariform drugs toxicity, statin toxicity, phenytoin or carbamazepine toxicity, letrozole toxicity, ricin poisoning, ivermectin toxicity, belinostat toxicity or dose selection, toxicity to dolutegravir, mycotoxicosis, ciguatera fish poisoning, lathyrism, cadmium poisoning, phenytoin toxicity, nerve agent poisoning, local anesthetic poisoning, fire ant poisoning, aflatoxicosis, black widow spider envenomation, platinum-induced ototoxicity, carbon monoxide poisoning, organophosphate poisoning, sulfur mustard poisoning, cardiac glycoside intoxication, monochloroacetic acid poisoning, chemotherapy-induced toxicity

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 3.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	2
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00753064	PHASE3	COMPLETED	AScVS and/ or Prazosin for Scorpion Envenomation
NCT06838715	Not specified	NOT_YET_RECRUITING	Role of Steroids and Extended Scorpion Anti-Venom Use in Cardiac Affection Among Scorpion Stung Pediatric Cases
NCT07408947	Not specified	COMPLETED	Clinical Severity in Scorpion Envenomation: Home Remedies, Delay to Medical Care, and Antivenom Dosing Strategies in an Emergency Department

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
PRAZOSIN	4	3
DEXAMETHASONE	4	1