Scrotal disorder
diseaseOn this page
Also known as disease of scrotumdisease or disorder of scrotumdisorder of scrotumscrotum diseasescrotum disease or disorder
Summary
Scrotal disorder (MONDO:0045003) is a disease and 7 clinical trials. Top therapeutic interventions include botulinum toxin type a, methoxyflurane, and sodium chloride. A subtype of male reproductive system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 7
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | scrotal disorder |
| Mondo ID | MONDO:0045003 |
| SNOMED CT | 49701002 |
| UMLS | C0268919 |
| MedGen | 541586 |
| Anatomy (UBERON) | UBERON:0001300 |
| Is cancer (heuristic) | no |
Also known as: disease of scrotum · disease or disorder of scrotum · disorder of scrotum · scrotum disease · scrotum disease or disorder
Disease family
This is a subtype of male reproductive system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › reproductive system disorder › male reproductive system disorder › scrotal disorder
Related subtypes (25): benign male reproductive system neoplasm, hematocele of tunica vaginalis testis, male genital organ stricture, male genital organ vascular disease, penile disorder, testicular disorder, prostate disorder, epididymitis, hydrocele, male infertility, male genital tuberculosis, spermatocele, dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome, cryptorchidism, diphallia, postorgasmic illness syndrome, penoscrotal transposition, congenital bilateral absence of vas deferens, posterior hypospadias, isolated micropenis, male reproductive system neoplasm, fournier gangrene, congenital agenesis of the scrotum, congenital megaprepuce, epididymis disease
Subtypes (2): varicocele, scrotum neoplasm
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 7.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE2 | 3 |
| PHASE4 | 2 |
| PHASE3 | 1 |
| Not specified | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05112081 | PHASE4 | NOT_YET_RECRUITING | Evaluation of Botox Treatment on Chronical Scrotal Pain |
| NCT07545278 | PHASE4 | RECRUITING | Is ICG Imaging Safe and Accurate to Predict Testicular Torsion? |
| NCT06242977 | PHASE3 | UNKNOWN | Efficacy of EMLA Cream Assisted Loco-sedation for Office-based Andrology Procedures |
| NCT06791070 | PHASE2 | RECRUITING | A Study of RC48-ADC Combined With JS001 for Advanced Extramammary Paget Disease of the Scrotum |
| NCT07117851 | PHASE2 | RECRUITING | A Study of Disitamab Vedotin + Bicalutamide in HER2/AR-Positive Scrotal Paget’s Disease |
| NCT07192198 | PHASE2 | COMPLETED | Efficacy of Inhaled Methoxyflurane (Penthrox) as Adjunct for Urologic Procedures Under Local Anesthetic: A Pilot Study |
| NCT03540056 | Not specified | UNKNOWN | Testicular Growth During Puberty in Boys With and Without a Left-sided Varicocele |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| BOTULINUM TOXIN TYPE A | 4 | 1 |
| METHOXYFLURANE | 4 | 1 |
| SODIUM CHLORIDE | 4 | 1 |