Scurvy
diseaseOn this page
Also known as ascorbic acid deficiencydeficiency of vitamin Cscorbutusvitamin C deficiencyvitamin C, inability to synthesise
Summary
Scurvy (MONDO:0009412) is a disease and 15 clinical trials. Top therapeutic interventions include cholecalciferol. A subtype of vitamin deficiency disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 15
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | scurvy |
| Mondo ID | MONDO:0009412 |
| EFO | EFO:1001169 |
| MeSH | D001206, D012614 |
| OMIM | 240400 |
| DOID | DOID:13577, DOID:13724 |
| ICD-10-CM | E54 |
| ICD-11 | 708602629 |
| NCIT | C35010 |
| SNOMED CT | 76169001 |
| UMLS | C0036474 |
| MedGen | 20684 |
| MedDRA | 10039768, 10047623 |
| Is cancer (heuristic) | no |
Also known as: ascorbic acid deficiency · deficiency of vitamin C · scorbutus · scurvy · vitamin C deficiency · vitamin C, inability to synthesise
Disease family
This is a subtype of vitamin deficiency disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › nutritional disorder › nutritional deficiency disease › vitamin deficiency disorder › scurvy
Related subtypes (7): nutritional biotin deficiency, vitamin K deficiency hemorrhagic disease, inborn vitamin metabolic disorder, vitamin A deficiency, vitamin B deficiency, vitamin D deficiency, vitamin deficiency related neuropathy
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
1 approved. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Ascorbic Acid | Approved (phase 4) |
Clinical trials & evidence
Clinical trials
Clinical trials: 15.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 10 |
| PHASE2 | 2 |
| PHASE1/PHASE2 | 1 |
| PHASE1 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00921622 | PHASE2 | COMPLETED | Vitamin Deficiency and Blood Pressure in Hospitalized Jewish General Hospital (JGH) Patients |
| NCT03224572 | PHASE1/PHASE2 | UNKNOWN | The Effect of Vitamin C on Quality of Life of Terminal Cancer Patients |
| NCT05733078 | PHASE2 | UNKNOWN | Effect of Vitamin C Supplementation in Patients With Primary Hypothyroidism |
| NCT02606773 | PHASE1 | COMPLETED | Novo C Plus Vitamin C Containing Dietary Supplement Bioavailability in Healthy Subjects |
| NCT05009355 | EARLY_PHASE1 | UNKNOWN | The Effect of Vitamin C on GCF Total Oxidant Capacity in Smoker Patients With Periodontitis |
| NCT06395259 | Not specified | ACTIVE_NOT_RECRUITING | Observational Study on the Variation of Ascorbic Acid in Patients Undergoing Solid Organ Transplantation |
| NCT06876545 | Not specified | NOT_YET_RECRUITING | Vitamin C Deficiency in Hospitalized Adults: Systematic Screening Vs. Traditional Judgment - a Before-and-After Observational Study |
| NCT02422901 | Not specified | UNKNOWN | A Long-term Study to Describe the Use of PASCORBIN® 7.5 g in Patients With Vitamin C Deficiency |
| NCT03807791 | Not specified | COMPLETED | Study of Prevalence and Risk Factors of Hypovitaminosis C in Long Term Care Unit |
| NCT03913468 | Not specified | COMPLETED | Outcomes of Septic Shock Patients Treated With a Metabolic Resuscitation Bundle Consisting of Intravenous Hydrocortisone, Ascorbic Acid and Thiamine. |
| NCT03938584 | Not specified | COMPLETED | The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients |
| NCT04284696 | Not specified | COMPLETED | Chewing Gum Containing Vitamin-c to Treat Emesis Gravidarum |
| NCT04886752 | Not specified | COMPLETED | The Effect of Liposome Vitamin C on the Absorption and Metabolism of the Human Body. |
| NCT05612867 | Not specified | COMPLETED | Low Dose Vitamin C in Burns >20% Compared to Previous Studies With High Dose Vitamin C |
| NCT07285109 | Not specified | COMPLETED | The Impact of Qualia Vitamin C+ on Blood Vitamin C Levels |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CHOLECALCIFEROL | 4 | 1 |
Related Atlas pages
- Drugs: Cholecalciferol