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Atlas / Disease / Seasonal affective disorder

Seasonal affective disorder

disease
On this page

Also known as sadSADS

Summary

Seasonal affective disorder (MONDO:0000694) is a disease and 26 clinical trials. Top therapeutic interventions include cholecalciferol, propranolol, and ramelteon. A subtype of depressive disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Clinical trials: 26

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

FieldValue
Canonical nameseasonal affective disorder
Mondo IDMONDO:0000694
MeSHD016574
DOIDDOID:0060167
SNOMED CT247803002
UMLSC0085159
MedGen38984
Is cancer (heuristic)no

Also known as: sad · SADS

Disease family

This is a subtype of depressive disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › mental disorder › mood disorder › depressive disorder › seasonal affective disorder

Related subtypes (6): major depressive disorder, melancholia, postpartum depression, bipolar depression, neurotic depression, mixed anxiety and depressive disorder

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 26.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified18
PHASE42
PHASE32
PHASE22
PHASE2/PHASE31
PHASE11

Top trials by phase / activity

NCTPhaseStatusTitle
NCT00502320PHASE4COMPLETEDRamelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder
NCT01462058PHASE4COMPLETEDThe Role of Vitamin D Supplementation on Well Being and Symptoms of Depression During the Winter Season in Health Service Staff
NCT00046241PHASE3COMPLETEDPrevention of Seasonal Affective Disorder
NCT00046449PHASE3COMPLETEDPrevention of Seasonal Affective Disorder
NCT00809523PHASE2/PHASE3COMPLETEDA Trial of Negative Ion Generation Versus Light-Emitting Diode Phototherapy for Seasonal Affective Disorder (SAD)
NCT00016666PHASE2COMPLETEDClinical Trial of Propranolol for Seasonal Affective Disorder
NCT00269633PHASE2COMPLETEDResearch Study of Treatment for Winter Depression With Different Colors of Light
NCT00076245PHASE1COMPLETEDCognitive Behavioral Therapy for the Treatment of Seasonal Affective Disorder (SAD)
NCT07161570Not specifiedNOT_YET_RECRUITINGVirtual Reality Digital Therapeutics for Seasonal Affective Disorder
NCT00001485Not specifiedCOMPLETEDEffects of Season on Melatonin Secretion in Healthy Men and Women and Patients With Seasonal Affective Disorder
NCT00006517Not specifiedCOMPLETEDClinical Trials of Three Non-Drug Treatments for Winter Depression (SAD)
NCT00114322Not specifiedUNKNOWNLight-Emitting Diode (LED) Light for Seasonal Affective Disorder (SAD) Treatment
NCT00139997Not specifiedCOMPLETEDEnvironmental Treatment for Seasonal Affective Disorder (SAD)
NCT01030276Not specifiedUNKNOWNBright Light Therapy in Seasonal Affective Disorder (SAD)
NCT01048294Not specifiedCOMPLETEDBlue Enriched Versus Standard Light Treatment for Seasonal Affective Disorder(SAD)
NCT01149135Not specifiedCOMPLETEDLow Intensity ‘Blue Light’ Treatment of Seasonal Affective Disorder
NCT01292889Not specifiedCOMPLETEDStudy of Genes in Relation to Seasonal Affective Disorder and Major Depressive Disorder
NCT01293409Not specifiedCOMPLETEDBright Light Therapy in Seasonal Affective Disorder (SAD)
NCT01462305Not specifiedCOMPLETED30-Minute Light Exposure for the Treatment of Seasonal Affective Disorder
NCT01714050Not specifiedCOMPLETEDCognitive-behavioral Therapy vs. Light Therapy for Preventing SAD Recurrence
NCT01784705Not specifiedCOMPLETEDTranscranial Bright Light Therapy in Seasonal Affective Disorder (SAD)
NCT02582398Not specifiedCOMPLETEDInfluence of Light Exposure on Cerebral MAO-A in Seasonal Affective Disorder and Healthy Controls Measured by PET
NCT03313674Not specifiedCOMPLETEDInvestigation of Seasonal Variations of Brain Structure and Connectivity in SAD
NCT03403959Not specifiedCOMPLETEDSeasonal Affective Disorder and Visual Impairment
NCT03691792Not specifiedCOMPLETEDOptimizing Long-Term Outcomes for Winter Depression With CBT-SAD and Light Therapy
NCT04251000Not specifiedCOMPLETEDInfrared Photomodulation Therapy for Seasonal Affective Disorder

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
CHOLECALCIFEROL41
PROPRANOLOL41
RAMELTEON41
DEXPROPRANOLOL21

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 19

This page pulls from 19 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvardoidefogenccgwasgwas_studyhgncmedgenmeshmimmondomondochildmondoparentorphanetsctidumls