Secondary dentine
diseaseOn this page
Also known as DENTIN SECONDDentin, SecondaryDentins, SecondaryIrregular dentinIrregular dentineReparative dentineSclerotic dentineSECOND DENTINSecondary DentinSecondary DentinsTertiary dentine
Summary
Secondary dentine (MONDO:0020818) is a disease and 2 clinical trials. Top therapeutic interventions include potassium iodide, silver diammine fluoride, and potassium ion. A subtype of dental pulp disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 2
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | secondary dentine |
| Mondo ID | MONDO:0020818 |
| MeSH | D003809 |
| SNOMED CT | 59818004 |
| UMLS | C0011434 |
| MedGen | 3746 |
| Is cancer (heuristic) | no |
Also known as: DENTIN SECOND · Dentin, Secondary · Dentins, Secondary · Irregular dentin · Irregular dentine · Reparative dentine · Sclerotic dentine · SECOND DENTIN · Secondary Dentin · Secondary dentin · secondary dentin · secondary dentine · Secondary Dentins · Tertiary dentine
Disease family
This is a subtype of dental pulp disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › tooth disorder › dental pulp disorder › secondary dentine
Related subtypes (6): pulp degeneration, dental pulp necrosis, pulp erosion, dental pulp calcification, pulpitis, exposure, dental pulp
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 2.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE2/PHASE3 | 1 |
| Not specified | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT04236830 | PHASE2/PHASE3 | COMPLETED | Silver Diamine Fluoride/ Potassium Iodide in Indirect Pulp Capping of Young Permanent Molars |
| NCT05211908 | Not specified | UNKNOWN | Clinical Performance of Different Adhesive Strategies With a Universal System in Sclerosed Dentin in NCCL: A Double-blind Randomized Clinical Trial. |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| POTASSIUM IODIDE | 4 | 1 |
| SILVER DIAMMINE FLUORIDE | 3 | 1 |
| POTASSIUM ION | 0 | 1 |