Secondary non-traumatic avascular necrosis
disease diseaseOn this page
Also known as secondary non-traumatic AVN
Summary
Secondary non-traumatic avascular necrosis (MONDO:0018376) is a disease. A subtype of secondary avascular necrosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Worldwide)
- Phenotypes (HPO): 13
Clinical features
Signs & symptoms
Clinical features (HPO)
13 HPO clinical features (Orphanet curated; top 13 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0010885 | Avascular necrosis | Very frequent (80-99%) |
| HP:0001376 | Limitation of joint mobility | Frequent (30-79%) |
| HP:0002653 | Bone pain | Frequent (30-79%) |
| HP:0002960 | Autoimmunity | Frequent (30-79%) |
| HP:0030955 | Alcoholism | Frequent (30-79%) |
| HP:0001288 | Gait disturbance | Occasional (5-29%) |
| HP:0001370 | Rheumatoid arthritis | Occasional (5-29%) |
| HP:0002664 | Neoplasm | Occasional (5-29%) |
| HP:0002725 | Systemic lupus erythematosus | Occasional (5-29%) |
| HP:0003549 | Abnormality of connective tissue | Occasional (5-29%) |
| HP:0004377 | Hematological neoplasm | Occasional (5-29%) |
| HP:0031520 | Groin pain | Occasional (5-29%) |
| HP:0100724 | Hypercoagulability | Very rare (<1-4%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | secondary non-traumatic avascular necrosis |
| Mondo ID | MONDO:0018376 |
| Orphanet | 399180 |
| UMLS | C5192430 |
| MedGen | 1684106 |
| GARD | 0021661 |
| Is cancer (heuristic) | no |
Also known as: secondary non-traumatic AVN
Disease family
This is a subtype of secondary avascular necrosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › bone disorder › osteonecrosis › avascular necrosis › secondary avascular necrosis › secondary non-traumatic avascular necrosis
Related subtypes (5): Gaucher disease type I, hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency, hereditary antithrombin deficiency, traumatic avascular necrosis, osteonecrosis of the jaw
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.