Secondary syringomyelia
disease diseaseOn this page
Summary
Secondary syringomyelia (MONDO:0020509) is a disease. A subtype of syringomyelia — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Phenotypes (HPO): 26
Clinical features
Signs & symptoms
Clinical features (HPO)
26 HPO clinical features (Orphanet curated; top 26 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0003396 | Syringomyelia | Obligate (100%) |
| HP:0040272 | Hyperintensity of MRI T2 signal of the spinal cord | Very frequent (80-99%) |
| HP:0001288 | Gait disturbance | Frequent (30-79%) |
| HP:0000224 | Decreased taste sensation | Frequent (30-79%) |
| HP:0001618 | Dysphonia | Frequent (30-79%) |
| HP:0002922 | Increased CSF protein concentration | Frequent (30-79%) |
| HP:0003401 | Paresthesia | Frequent (30-79%) |
| HP:0003418 | Back pain | Frequent (30-79%) |
| HP:0003473 | Fatigable weakness | Frequent (30-79%) |
| HP:0003474 | Somatic sensory dysfunction | Frequent (30-79%) |
| HP:0006824 | Cranial nerve paralysis | Frequent (30-79%) |
| HP:0007209 | Facial paralysis | Frequent (30-79%) |
| HP:0010532 | Paroxysmal vertigo | Frequent (30-79%) |
| HP:0010550 | Paraplegia | Frequent (30-79%) |
| HP:0010871 | Sensory ataxia | Frequent (30-79%) |
| HP:0012229 | CSF pleocytosis | Frequent (30-79%) |
| HP:0000622 | Blurred vision | Occasional (5-29%) |
| HP:0000639 | Nystagmus | Occasional (5-29%) |
| HP:0001250 | Seizure | Occasional (5-29%) |
| HP:0001283 | Bulbar palsy | Occasional (5-29%) |
| HP:0002073 | Progressive cerebellar ataxia | Occasional (5-29%) |
| HP:0002858 | Meningioma | Occasional (5-29%) |
| HP:0003409 | Distal sensory impairment of all modalities | Occasional (5-29%) |
| HP:0007024 | Pseudobulbar paralysis | Occasional (5-29%) |
| HP:0007305 | CNS demyelination | Occasional (5-29%) |
| HP:0100518 | Dysuria | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | secondary syringomyelia |
| Mondo ID | MONDO:0020509 |
| Orphanet | 99857 |
| UMLS | C4749399 |
| MedGen | 1649806 |
| GARD | 0019692 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of syringomyelia. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › spinal cord disorder › syringomyelia › secondary syringomyelia
Related subtypes (1): primary syringomyelia
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.