Selective immunoglobulin deficiency disease

Summary

Selective immunoglobulin deficiency disease (MONDO:0003739) is a disease. A subtype of B cell deficiency — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	selective immunoglobulin deficiency disease
Mondo ID	MONDO:0003739
DOID	DOID:6025
NCIT	C27870
UMLS	C1335942
MedGen	235584
GARD	0023643
Is cancer (heuristic)	no

Also known as: selective Immunoglobulin isotype deficiency

Disease family

This is a subtype of B cell deficiency. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › immune system disorder › inborn error of immunity › B cell deficiency › selective immunoglobulin deficiency disease

Related subtypes (4): immunoglobulin beta deficiency, hyperimmunoglobulin syndrome, agammaglobulinemia, PAX5-related B lymphopenia and autism spectrum disorder

Subtypes (2): dysgammaglobulinemia, selective IgD deficiency disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.