Simple cryoglobulinemia

Summary

Simple cryoglobulinemia (MONDO:0019606) is a disease. A subtype of acquired peripheral neuropathy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 55

Clinical features

Signs & symptoms

Clinical features (HPO)

55 HPO clinical features (Orphanet curated; top 50 by frequency):

HPO ID	Term	Frequency
HP:0000979	Purpura	Very frequent (80-99%)
HP:0001871	Abnormality of blood and blood-forming tissues	Very frequent (80-99%)
HP:0410135	Cold urticaria	Very frequent (80-99%)
HP:0001955	Unexplained fevers	Frequent (30-79%)
HP:0003496	Increased circulating IgM level	Frequent (30-79%)
HP:0006121	Acral ulceration	Frequent (30-79%)
HP:0007067	Distal peripheral sensory neuropathy	Frequent (30-79%)
HP:0007141	Sensorimotor neuropathy	Frequent (30-79%)
HP:0009830	Peripheral neuropathy	Frequent (30-79%)
HP:0011355	Localized skin lesion	Frequent (30-79%)
HP:0012378	Fatigue	Frequent (30-79%)
HP:0030880	Raynaud phenomenon	Frequent (30-79%)
HP:0031047	Paraproteinemia	Frequent (30-79%)
HP:0032018	Multiple mononeuropathy	Frequent (30-79%)
HP:0033260	Livedo racemosa	Frequent (30-79%)
HP:0000077	Abnormality of the kidney	Occasional (5-29%)
HP:0000083	Renal insufficiency	Occasional (5-29%)
HP:0000093	Proteinuria	Occasional (5-29%)
HP:0000793	Membranoproliferative glomerulonephritis	Occasional (5-29%)
HP:0000822	Hypertension	Occasional (5-29%)
HP:0001369	Arthritis	Occasional (5-29%)
HP:0001824	Weight loss	Occasional (5-29%)
HP:0002633	Vasculitis	Occasional (5-29%)
HP:0002829	Arthralgia	Occasional (5-29%)
HP:0002907	Microscopic hematuria	Occasional (5-29%)
HP:0003401	Paresthesia	Occasional (5-29%)
HP:0005508	Monoclonal immunoglobulin M proteinemia	Occasional (5-29%)
HP:0006775	Multiple myeloma	Occasional (5-29%)
HP:0010833	Spontaneous pain sensation	Occasional (5-29%)
HP:0011276	Vascular skin abnormality	Occasional (5-29%)
HP:0012191	B-cell lymphoma	Occasional (5-29%)
HP:0012574	Mesangial hypercellularity	Occasional (5-29%)
HP:0032290	Monoclonal elevation of IgG	Occasional (5-29%)
HP:0005550	Chronic lymphatic leukemia	Very rare (<1-4%)
HP:0006562	Viral hepatitis	Very rare (<1-4%)
HP:0006824	Cranial nerve paralysis	Very rare (<1-4%)
HP:0011024	Abnormality of the gastrointestinal tract	Very rare (<1-4%)
HP:0032335	Monoclonal elevation of circulating IgA	Very rare (<1-4%)
HP:0000100	Nephrotic syndrome	Very rare (<1-4%)
HP:0000123	Nephritis	Very rare (<1-4%)
HP:0001250	Seizure	Very rare (<1-4%)
HP:0001297	Stroke	Very rare (<1-4%)
HP:0001627	Abnormal heart morphology	Very rare (<1-4%)
HP:0001635	Congestive heart failure	Very rare (<1-4%)
HP:0001658	Myocardial infarction	Very rare (<1-4%)
HP:0001701	Pericarditis	Very rare (<1-4%)
HP:0002011	Morphological central nervous system abnormality	Very rare (<1-4%)
HP:0002027	Abdominal pain	Very rare (<1-4%)
HP:0002088	Abnormal lung morphology	Very rare (<1-4%)
HP:0002239	Gastrointestinal hemorrhage	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	simple cryoglobulinemia
Mondo ID	MONDO:0019606
Orphanet	91139
SNOMED CT	723674005
UMLS	C4510006
MedGen	1383731
GARD	0025143
Is cancer (heuristic)	no

Also known as: cryoglobulinemia type 1

Disease family

Classification path: disease › human disease › disease by body system or component › nervous system disorder › peripheral nervous system disorder › peripheral neuropathy › acquired peripheral neuropathy › simple cryoglobulinemia

Related subtypes (11): axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy, cranial neuralgia, neuralgic amyotrophy, POEMS syndrome, non-recovering obstetric brachial plexus lesion, anterior cutaneous nerve entrapment syndrome, pudendal neuralgia, polyneuropathy associated with IgM monoclonal gammapathy with anti-MAG, multifocal motor neuropathy, CANOMAD syndrome, radiation-induced plexopathy

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.