Sleep-wake disorder

Summary

Sleep-wake disorder (MONDO:0003406) is a disease (an umbrella term covering 12 Mondo subtypes) and 515 clinical trials. Top therapeutic interventions include zolpidem, prazosin, and melatonin. A subtype of sleep disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Umbrella term: 12 Mondo subtypes
• Clinical trials: 515

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	sleep-wake disorder
Mondo ID	MONDO:0003406
MeSH	D012893
DOID	DOID:535
ICD-10-CM	G47
SNOMED CT	39898005
UMLS	C4042891
MedGen	875755
Is cancer (heuristic)	no

Also known as: disorder of sleep-wake cycle · disorder, sleep · disorder, sleep wake · disorders, sleep · disorders, sleep wake · long sleeper syndrome · long sleeper syndromes · neurogenic tachypnea, sleep-related · neurogenic Tachypneas, sleep-related · phenotype, short sleep · phenotypes, short sleep · short sleep phenotype · short sleep phenotypes · short sleeper syndrome · short sleeper syndromes · sleep disorder · sleep disorders · sleep phenotypes, short · sleep related neurogenic tachypnea · sleep wake disorder (+18 more)

Disease family

This is a subtype of sleep disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › sleep disorder › sleep-wake disorder

Related subtypes (4): insomnia, nocturnal paroxysmal dystonia, parasomnia, sleepwalking type, parasomnia, sleep terrors type

Subtypes (12): bruxism, recurrent hypersomnia, sleep apnea syndrome, hypersomnia, periodic limb movement disorder, REM sleep behavior disorder, autosomal dominant cerebellar ataxia, deafness and narcolepsy, hereditary sensory neuropathy-deafness-dementia syndrome, autoimmune encephalopathy with parasomnia and obstructive sleep apnea, narcolepsy, circadian rhythm sleep disorder, sleep disorder, initiating and maintaining sleep

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

1 approved. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Tasimelteon	Approved (phase 4)

Clinical trials & evidence

Clinical trials

Clinical trials: 515.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	419
PHASE4	31
PHASE3	24
PHASE2	24
PHASE1	8
PHASE2/PHASE3	3
PHASE1/PHASE2	3
EARLY_PHASE1	3

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04641819	PHASE4	ACTIVE_NOT_RECRUITING	Yangzheng Compound Mixture in the Treatment of Sleep Disorder in Cancer Patients
NCT06778811	PHASE4	RECRUITING	Clinical Study of Perioperative Sleep Disorders in Cardiac Surgery
NCT00132821	PHASE4	COMPLETED	Impact of Smoking Cessation on Sleep - 5
NCT00177216	PHASE4	COMPLETED	Characteristics of Sleep Patterns in Young Adults With and Without Insomnia
NCT00195520	PHASE4	COMPLETED	Study Evaluating Totelle® in Menopausal Symptoms and Sexual Function
NCT00359216	PHASE4	COMPLETED	The Effects of Mometasone Furoate Nasal Spray in Subjects With Sleep-disordered Breathing (SDB) Associated With Perennial Allergic Rhinitis (Study P04726)
NCT00507546	PHASE4	COMPLETED	Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia
NCT00518986	PHASE4	COMPLETED	Efficacy and Safety of Armodafinil for Adults With Excessive Sleepiness Obstructive Sleep Apnea/Hypopnea and Depression
NCT00530556	PHASE4	COMPLETED	Insomnia and Daytime Function in Osteoarthritis
NCT00749814	PHASE4	UNKNOWN	Sleep Disturbances in Hospitalized Children
NCT00822679	PHASE4	COMPLETED	Eszopiclone and Inflammatory Mediators in Patients With Acute Coronary Syndrome
NCT01024192	PHASE4	COMPLETED	Efficacy and Safety Assessment of ZOlpidem (Stilnox CR) in Patients With Chronic insomNIA
NCT01033565	PHASE4	TERMINATED	Melatonin CR for the Treatment of Impaired Sleep Maintenance in 4-8 Year Old Children With Autism Spectrum Disorders
NCT01097382	PHASE4	COMPLETED	Sleep Satisfaction and Psychomotor Performance of Adults
NCT01156051	PHASE4	TERMINATED	Effect of Guanfacine Extended-Release on Attention Deficit Hyperactivity Disorder (ADHD)-Associated Insomnia
NCT01164592	PHASE4	COMPLETED	Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation
NCT01234675	PHASE4	COMPLETED	The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia
NCT02477527	PHASE4	COMPLETED	Atripla to Stribild Switch Study to Evaluate Sleep Disturbances
NCT03066518	PHASE4	COMPLETED	Effect of Melatonin on Sleep Quality in Patients Dementia
NCT03335527	PHASE4	COMPLETED	Impacts of Low-Dose Dexmedetomidine on Sleep Quality in Mechanically Ventilated ICU Patients
NCT03522207	PHASE4	TERMINATED	Accuracy and Efficacy of Trazodone (Desyrel) on Sleep Quality and Pain Management of TMD Patient
NCT03818581	PHASE4	COMPLETED	Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes
NCT03977441	PHASE4	UNKNOWN	the Efficacy and Safety of Agomelatine in the Patients With Parkinson’s Disease
NCT04318067	PHASE4	UNKNOWN	Melatonin in ADHD and Sleep Problems
NCT04528173	PHASE4	TERMINATED	Opioid-Free Anesthetic for Tonsillectomy
NCT04610827	PHASE4	TERMINATED	Oral Iron Frequency for Childhood Restless Leg Syndrome/Periodic Limb Movement Disorder
NCT04693533	PHASE4	TERMINATED	Fremanezumab, Migraine and Sleep
NCT04706091	PHASE4	COMPLETED	Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia
NCT05325762	PHASE4	UNKNOWN	Effect of Propofol on Postoperative Sleep Quality in Elderly Patients With Sleep Disorders
NCT05950932	PHASE4	UNKNOWN	Effects of Melissa Extract on Sleep Characteristics
NCT06117969	PHASE4	UNKNOWN	the Effects of Different Therapy Regimens on Menopausal Sleep Disorders
NCT04652882	PHASE3	RECRUITING	Evaluating the Effects of Tasimelteon vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD)
NCT06701396	PHASE3	RECRUITING	Evaluating the Effects of Tasimelteon Vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD) and the CRY1Δ11 Variant
NCT00075842	PHASE3	COMPLETED	(Valerian) for Improving Sleep in Patients With Cancer Receiving Adjuvant Therapy
NCT00155441	PHASE3	UNKNOWN	Effects of Cognitive-Behavioral Therapy on Sleep Disturbance in Peritoneal Dialysis Patients
NCT00256685	PHASE3	COMPLETED	Study Evaluating DVS-233 SR to Treat Vasomotor Systems Associated With Menopause
NCT00283946	PHASE3	COMPLETED	A Double-blind, Group-comparison Study Using Zolpidem (Myslee) as a Comparative Drug in Patients With Insomnia
NCT00532493	PHASE3	COMPLETED	Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD
NCT00561574	PHASE3	COMPLETED	A Long-Term Safety Study of Org 50081 (Esmirtazapine) in Elderly Outpatients With Chronic Primary Insomnia (176005/P05697/MK-8265-001)
NCT00561821	PHASE3	COMPLETED	Efficacy and Safety Study of Org 50081 (Esmirtazapine) in Elderly Participants (P05709)

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ZOLPIDEM	4	12
PRAZOSIN	4	10
MELATONIN	4	6
BUPROPION	4	3
ESZOPICLONE	4	3
GUANFACINE	4	3
PITOLISANT	4	3
RAMELTEON	4	3
TAMOXIFEN	4	3
TRAZODONE	4	3
VENLAFAXINE	4	3
ZOPICLONE	4	3
KETOROLAC	4	2
SUVOREXANT	4	2
TASIMELTEON	4	2
ARMODAFINIL	4	1
DONEPEZIL HYDROCHLORIDE	4	1
ESCITALOPRAM	4	1
ETRAVIRINE	4	1
EXEMESTANE	4	1
FERROUS SULFATE	4	1
ISTRADEFYLLINE	4	1
METHADONE HYDROCHLORIDE	4	1
METHYLPHENIDATE HYDROCHLORIDE	4	1
MILNACIPRAN	4	1
MIRTAZAPINE	4	1
MODAFINIL	4	1
NICOTINE	4	1
OXYGEN	4	1
PRAMIPEXOLE	4	1