Snakebite envenomation

Summary

Snakebite envenomation (MONDO:0018669) is a disease and 1 clinical trial. A subtype of poisoning — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: 1-9 / 100 000 (Europe) [Orphanet-validated]
• Phenotypes (HPO): 34
• Clinical trials: 1

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Point prevalence	1-9 / 100 000		Europe	Validated

Signs & symptoms

Clinical features (HPO)

34 HPO clinical features (Orphanet curated; top 34 by frequency):

HPO ID	Term	Frequency
HP:0000969	Edema	Very frequent (80-99%)
HP:0010783	Erythema	Frequent (30-79%)
HP:0011355	Localized skin lesion	Frequent (30-79%)
HP:0012531	Pain	Frequent (30-79%)
HP:0031364	Ecchymosis	Frequent (30-79%)
HP:0000707	Abnormality of the nervous system	Occasional (5-29%)
HP:0001297	Stroke	Occasional (5-29%)
HP:0001649	Tachycardia	Occasional (5-29%)
HP:0001873	Thrombocytopenia	Occasional (5-29%)
HP:0001892	Abnormal bleeding	Occasional (5-29%)
HP:0001928	Abnormality of coagulation	Occasional (5-29%)
HP:0002013	Vomiting	Occasional (5-29%)
HP:0002170	Intracranial hemorrhage	Occasional (5-29%)
HP:0002637	Cerebral ischemia	Occasional (5-29%)
HP:0003201	Rhabdomyolysis	Occasional (5-29%)
HP:0003470	Paralysis	Occasional (5-29%)
HP:0003713	Muscle fiber necrosis	Occasional (5-29%)
HP:0007024	Pseudobulbar paralysis	Occasional (5-29%)
HP:0009088	Speech articulation difficulties	Occasional (5-29%)
HP:0011900	Hypofibrinogenemia	Occasional (5-29%)
HP:0000225	Gingival bleeding	Very rare (<1-4%)
HP:0000421	Epistaxis	Very rare (<1-4%)
HP:0001658	Myocardial infarction	Very rare (<1-4%)
HP:0001919	Acute kidney injury	Very rare (<1-4%)
HP:0002014	Diarrhea	Very rare (<1-4%)
HP:0002068	Neuromuscular dysphagia	Very rare (<1-4%)
HP:0002203	Respiratory paralysis	Very rare (<1-4%)
HP:0002615	Hypotension	Very rare (<1-4%)
HP:0002878	Respiratory failure	Very rare (<1-4%)
HP:0002902	Hyponatremia	Very rare (<1-4%)
HP:0005521	Disseminated intravascular coagulation	Very rare (<1-4%)
HP:0030149	Cardiogenic shock	Very rare (<1-4%)
HP:0040075	Hypopituitarism	Very rare (<1-4%)
HP:0100665	Angioedema	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	snakebite envenomation
Mondo ID	MONDO:0018669
Orphanet	449285
SNOMED CT	61288004
GARD	0021881
Is cancer (heuristic)	no

Also known as: poisoning by venomous snake

Disease family

This is a subtype of poisoning. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › poisoning › snakebite envenomation

Related subtypes (58): toxic oil syndrome, infantile mercury poisoning, ketamine-induced biliary dilatation, manganese poisoning, cyanide-induced parkinsonism, colchicine poisoning, methanol poisoning, ethylene glycol poisoning, paraquat poisoning, lead poisoning, mercury poisoning, acute opioid poisoning, acute tricyclic antidepressant poisoning, acute poisoning by drugs with membrane-stabilizing effect, paracetamol poisoning, cyanide poisoning, scorpion envenomation, argyria, acute ackee fruit intoxication, cocaine intoxication, systemic monochloroacetate poisoning, water intoxication, cassavism, formaldehyde poisoning, heavy metal poisoning, abacavir toxicity, allopurinol toxicity, codeine toxicity, efavirenz toxicity, flucloxacilline toxicity, isoniazid toxicity, raltegravir toxicity, voriconazole toxicity, curariform drugs toxicity, statin toxicity, phenytoin or carbamazepine toxicity, letrozole toxicity, ricin poisoning, ivermectin toxicity, belinostat toxicity or dose selection, toxicity to dolutegravir, mycotoxicosis, ciguatera fish poisoning, lathyrism, cadmium poisoning, phenytoin toxicity, nerve agent poisoning, local anesthetic poisoning, fire ant poisoning, aflatoxicosis, black widow spider envenomation, platinum-induced ototoxicity, carbon monoxide poisoning, organophosphate poisoning, sulfur mustard poisoning, cardiac glycoside intoxication, monochloroacetic acid poisoning, chemotherapy-induced toxicity

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06622343	Not specified	COMPLETED	Predictive Modeling of Necrotizing Skin Infections in Snakebite Patients