Soft tissue neoplasm
disease diseaseOn this page
Also known as neoplasm of soft tissueneoplasm of the soft tissuesoft tissue tumorsoft tissue tumorssoft tissue tumoursoft tissue tumoursSOFT_TISSUEtumor of soft tissuetumor of the soft tissuetumour of soft tissuetumour of the soft tissue
Summary
Soft tissue neoplasm (MONDO:0006424) is a cancer (an umbrella term covering 18 Mondo subtypes) and 26 clinical trials. Top therapeutic interventions include binimetinib. A subtype of connective and soft tissue neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Umbrella term: 18 Mondo subtypes
- Clinical trials: 26
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | soft tissue neoplasm |
| Mondo ID | MONDO:0006424 |
| EFO | EFO:1000541 |
| NCIT | C3377 |
| SNOMED CT | 387837005 |
| UMLS | C0037579 |
| MedGen | 11495 |
| Is cancer (heuristic) | yes |
Also known as: neoplasm of soft tissue · neoplasm of the soft tissue · soft tissue neoplasm · soft tissue tumor · soft tissue tumors · soft tissue tumour · soft tissue tumours · SOFT_TISSUE · tumor of soft tissue · tumor of the soft tissue · tumour of soft tissue · tumour of the soft tissue
Disease family
This is a subtype of connective and soft tissue neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › connective and soft tissue neoplasm › soft tissue neoplasm
Related subtypes (2): benign connective and soft tissue neoplasm, synovial chondromatosis
Subtypes (18): synovium neoplasm, central nervous system mesenchymal non-meningothelial tumor, mediastinal mesenchymal tumor, nodular fasciitis, mixed endometrial stromal and smooth muscle tumor, neoplasm with perivascular epithelioid cell differentiation, desmoid tumor, congenital epulis, inflammatory myofibroblastic tumor, juvenile hyaline fibromatosis, kaposiform hemangioendothelioma, glomus tumor, Mazabraud syndrome, melanoma of soft tissue, malignant soft tissue neoplasm, soft tissue amyloid neoplasm, fibromyxoid tumor, benign soft tissue neoplasm
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated or in trials for this disease
No drug has an approved disease-direct ChEMBL indication for this disease.
1 drug in clinical trials for this disease (phase 2–3, investigational): efficacy not established — a trial record, not an indication.
| Drug | Highest phase |
|---|---|
| Trabectedin | Phase 2 |
Clinical trials & evidence
Clinical trials
Clinical trials: 26.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 21 |
| PHASE1 | 2 |
| EARLY_PHASE1 | 2 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02285439 | PHASE1/PHASE2 | COMPLETED | Study of MEK162 for Children With Low-Grade Gliomas |
| NCT01552434 | PHASE1 | TERMINATED | Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease |
| NCT02441972 | PHASE1 | UNKNOWN | Clinic Study of 18F-Al-NOTA-PRGD2 in Cancer Diagnostics |
| NCT01630239 | EARLY_PHASE1 | COMPLETED | MR-Guided Laser Ablation of Hepatic Tumors |
| NCT03867188 | EARLY_PHASE1 | TERMINATED | Liposomal Bupivacaine (Exparel) in Sarcomas |
| NCT03737734 | Not specified | ACTIVE_NOT_RECRUITING | Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia (DaRT) |
| NCT03889899 | Not specified | RECRUITING | Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia. |
| NCT04394052 | Not specified | RECRUITING | Novel Imaging Techniques for the Characterization of Musculoskeletal Tumors II |
| NCT04534127 | Not specified | RECRUITING | Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia |
| NCT06979115 | Not specified | NOT_YET_RECRUITING | Investigation Into the Safety and Efficacy of ICG-Labeled Fluorescence Imaging Technology in Guiding the Resection of Bone and Soft Tissue Tumors |
| NCT07062003 | Not specified | RECRUITING | Minibeam Radiation Therapy With Tungsten Slit Collimator for the Treatment of Recurrent or Metastatic Skin or Soft Tissue Tumors, MBRT1 Trial |
| NCT07470008 | Not specified | RECRUITING | Prospective Registry of Histotripsy for Soft Tissue Tumors |
| NCT07606287 | Not specified | NOT_YET_RECRUITING | Studying the Workflow of the American College of Surgeons Geriatric Surgery Program to Improve Clinical Outcomes in Older Adults Undergoing Surgery at the James Cancer Hospital |
| NCT00041886 | Not specified | COMPLETED | Radiofrequency Ablation of Painful Soft Tissue Neoplasms |
| NCT00173355 | Not specified | UNKNOWN | Clinical Outcome of Pediatric Dermatofibrosarcoma Protuberans |
| NCT01017978 | Not specified | COMPLETED | Quantitative MR Biomarkers for Sarcoma Treatment |
| NCT01276483 | Not specified | COMPLETED | Treatment Response Evaluation in Gastrointestinal Stromal Tumor (GIST) Patients |
| NCT01965002 | Not specified | TERMINATED | Feasibility of ExAblate MRI Guided High Intensity Focused Ultrasound Tx of Soft Tissue Tumors |
| NCT02557243 | Not specified | COMPLETED | Malignant Pediatric Soft Tissue & Bone Tumors of the Extremities: A Retrospective Study |
| NCT02775799 | Not specified | TERMINATED | National Swiss Sarcoma Cohort Study |
| NCT02834585 | Not specified | UNKNOWN | Magnetic Resonance Imaging or Ultrasound in Soft Tissue Tumors (MUSTT) |
| NCT02895633 | Not specified | UNKNOWN | Osteoarticular Tumor Characterization by Advanced Imaging |
| NCT03452644 | Not specified | COMPLETED | US-Guided Biopsy in the Diagnosis of Musculoskeletal Soft-Tissue Tumors |
| NCT03886181 | Not specified | TERMINATED | Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal and Superficial Soft Tissue Neoplasia (DaRT) |
| NCT04300179 | Not specified | COMPLETED | Ewing Sarcoma Family of Tumors (ESFT): A 15-year Experience From a Tertiary Care Cancer Center in Upper Egypt |
| NCT04540588 | Not specified | COMPLETED | Retreatment With Intratumoral Diffusing Alpha Radiation Emitters |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| BINIMETINIB | 4 | 1 |
Related Atlas pages
- Drugs: Binimetinib