Solitary bone cyst

Summary

Solitary bone cyst (MONDO:0019372) is a disease and 13 clinical trials. A subtype of bone neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 17
• Clinical trials: 13

Clinical features

Signs & symptoms

Clinical features (HPO)

17 HPO clinical features (Orphanet curated; top 17 by frequency):

HPO ID	Term	Frequency
HP:0012064	Unicameral bone cyst	Very frequent (80-99%)
HP:0002653	Bone pain	Frequent (30-79%)
HP:0002756	Pathologic fracture	Frequent (30-79%)
HP:0003926	Abnormality of the humeral diaphysis	Frequent (30-79%)
HP:0006431	Proximal femoral metaphyseal abnormality	Frequent (30-79%)
HP:0100253	Abnormality of the medullary cavity of the long bones	Frequent (30-79%)
HP:0002992	Abnormality of tibia morphology	Occasional (5-29%)
HP:0012428	Prominent calcaneus	Occasional (5-29%)
HP:0000707	Abnormality of the nervous system	Very rare (<1-4%)
HP:0002143	Abnormality of the spinal cord	Very rare (<1-4%)
HP:0002696	Abnormal parietal bone morphology	Very rare (<1-4%)
HP:0002867	Abnormality of the ilium	Very rare (<1-4%)
HP:0003172	Abnormality of the pubic bone	Very rare (<1-4%)
HP:0003312	Abnormal form of the vertebral bodies	Very rare (<1-4%)
HP:0003418	Back pain	Very rare (<1-4%)
HP:0003979	Lytic defects of the radius	Very rare (<1-4%)
HP:0100748	Muscular edema	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	solitary bone cyst
Mondo ID	MONDO:0019372
MeSH	D001845
Orphanet	83468
ICD-10-CM	M85.4
ICD-11	987501456
NCIT	C2904
SNOMED CT	203467005
UMLS	C0005937
MedGen	2696
GARD	0019039
Is cancer (heuristic)	no

Also known as: bone cyst · cyst of bone · cyst of the bone · simple bone cyst · solitary cyst · unicameral bone cyst

Disease family

This is a subtype of bone neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › bone disorder › bone neoplasm › solitary bone cyst

Related subtypes (19): bone benign neoplasm, bone cancer, notochordal tumor, hereditary multiple osteochondromas, diaphyseal medullary stenosis-bone malignancy syndrome, hyperparathyroidism 1, hyperparathyroidism 2 with jaw tumors, OSLAM syndrome, Ollier disease, neonatal severe primary hyperparathyroidism, hyperparathyroidism 3, juvenile hyaline fibromatosis, aneurysmal bone cyst, Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone, neoplasm of femur, vascular bone neoplasm, hyperparathyroidism 4, skull neoplasm, congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 13.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	10
PHASE3	1
PHASE2	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02193841	PHASE3	RECRUITING	Simple Bone Cysts in Kids
NCT00459641	PHASE2	WITHDRAWN	Safety and Tolerability of I-040302 in Children and Young Adults With Solitary Bone Cysts
NCT01207193	PHASE1	COMPLETED	Treatment Of Bone Cyst With Bone Marrow Mesenchymal Cell Transplantation
NCT07066228	Not specified	RECRUITING	Bone Reconstruction With Autologous Bone Marrow Mesenchymal Stem Cells in Vitro to Repair Long Tubular Bone Defects
NCT02567084	Not specified	COMPLETED	Complete Twelve Month Bone Remodeling With a Bi-phasic Injectable Bone Substitute in Benign Bone Tumors
NCT02575352	Not specified	UNKNOWN	Calcium Phosphate Cement Registry (CPC Registry)
NCT02616757	Not specified	WITHDRAWN	Quantitative Ultrasound for the Evaluation of Simple Bone Cyst Healing
NCT03076138	Not specified	COMPLETED	Gene-activated Bone Substitute for Maxillofacial Bone Regeneration
NCT03724630	Not specified	UNKNOWN	The Results of Multiple Aspirations and Injections of Unicameral Bone Cyst by Methyl Prednisolone Acetate
NCT04737590	Not specified	UNKNOWN	Bioactive Glass or Allogenic Bone in Pediatric Bone Cysts
NCT05075148	Not specified	UNKNOWN	Aneurysmal Bone Cyst Imaging After Interventional Radiology Treatment
NCT05880628	Not specified	UNKNOWN	Evaluation of Faisability, Safety and Effectiveness and of Discogel in Patients With Aneurysmal and Simple Bone Cysts
NCT07379008	Not specified	COMPLETED	Safety and Efficacy of Non-Setting Paste in Bone Defect Reconstruction