Specific phobia
diseaseOn this page
Also known as simple phobia
Summary
Specific phobia (MONDO:0012000) is a disease and 58 clinical trials. Top therapeutic interventions include cycloserine and levcycloserine. A subtype of phobic disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 58
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | specific phobia |
| Mondo ID | MONDO:0012000 |
| EFO | EFO:1001918 |
| MeSH | C562465 |
| OMIM | 608251 |
| DOID | DOID:599 |
| ICD-11 | 239513569 |
| NCIT | C35284 |
| SNOMED CT | 54587008 |
| UMLS | C0236801 |
| MedGen | 65932 |
| Is cancer (heuristic) | no |
Also known as: simple phobia
Disease family
This is a subtype of phobic disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › mental disorder › anxiety disorder › phobic disorder › specific phobia
Related subtypes (2): social phobia, agoraphobia
Subtypes (3): nosophobia, animal phobia, flying phobia
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 58.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 52 |
| PHASE1/PHASE2 | 4 |
| PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00872716 | PHASE2 | COMPLETED | Quetiapine in Specific Phobia |
| NCT01491880 | PHASE1/PHASE2 | COMPLETED | Treatment Study for Rural Latino Youth With Anxiety |
| NCT01923896 | PHASE1/PHASE2 | COMPLETED | D-cycloserine and Treatment of Feeding Disorders |
| NCT02051192 | PHASE1/PHASE2 | COMPLETED | Brief Behavioral Treatment for Anxiety in Young Children |
| NCT02160470 | PHASE1/PHASE2 | COMPLETED | Enhancing Exposure Therapy for Snake and Spider Phobias |
| NCT01268657 | PHASE1 | COMPLETED | Intervention for Anxiety After Falls |
| NCT01075672 | Not specified | ACTIVE_NOT_RECRUITING | Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals |
| NCT04563390 | Not specified | RECRUITING | Effectiveness of a Projection-based Augmented Reality Exposure System in Treating Cockroach Phobia. |
| NCT05118594 | Not specified | NOT_YET_RECRUITING | Testing a Precision Psychotherapy System for Low-income Patients |
| NCT06661460 | Not specified | RECRUITING | Internet-Delivered Cognitive Behavioral Intervention for Youths With Anxiety Disorders |
| NCT06788119 | Not specified | RECRUITING | Analyzing the Benefits of Using SYMPTOMS-JIT for in Vivo Exposure in Anxiety Disorders |
| NCT06942429 | Not specified | RECRUITING | Stepped Versus Stratified Care for Anxiety Disorders in Youth |
| NCT07228143 | Not specified | RECRUITING | Stepped Care Treatment for Anxiety Resilience |
| NCT00184145 | Not specified | WITHDRAWN | EMDR in the Treatment of Specific Phobia. |
| NCT00509951 | Not specified | COMPLETED | Parent-Augmented Cognitive Behavioral Therapy to Treat Children With Specific Phobias |
| NCT01450306 | Not specified | COMPLETED | Exposure, D-cycloserine Enhancement, and Functional Magnetic Resonance Imaging (fMRI) in Snake Phobics |
| NCT01849432 | Not specified | COMPLETED | Study of Brain Circuitry in Anxiety Disorders |
| NCT01919970 | Not specified | COMPLETED | Exposure-Focused Family-Based CBT for Youth With ASD and Comorbid Anxiety |
| NCT01947647 | Not specified | COMPLETED | Transdiagnostic Psychotherapy for Veterans With Mood and Anxiety Disorders |
| NCT01979263 | Not specified | TERMINATED | Attention Bias Modification Treatment for Anxious Youth |
| NCT02028247 | Not specified | COMPLETED | Psychotherapy for Anxiety in Children With Autism Spectrum Disorder |
| NCT02085343 | Not specified | UNKNOWN | Anti-phobic and Safety Behaviors in the Treatment of Acrophobia |
| NCT02305537 | Not specified | COMPLETED | Building an Outcomes Assessment Infrastructure to Assess Anxiety Treatment |
| NCT02306356 | Not specified | COMPLETED | Internet-delivered Treatment for Children With Anxiety Disorders in a Rural Area; an Open Trial in a Clinical Setting |
| NCT02554838 | Not specified | COMPLETED | How to Act on the Mobility Restriction Linked to Senior’s Phobia of Falling |
| NCT02605668 | Not specified | COMPLETED | Providing Tools for Effective Care and Treatment of Anxiety Disorders |
| NCT02739607 | Not specified | UNKNOWN | Internet-delivered Transdiagnostic Intervention for Anxiety and Depression |
| NCT02756507 | Not specified | COMPLETED | Transdiagnostic REBT Prevention Program for Adolescents |
| NCT02810171 | Not specified | COMPLETED | Dimensional Brain Behavior Predictors of CBT Outcomes in Pediatric Anxiety |
| NCT02905279 | Not specified | TERMINATED | Spider Phobia Opposite Action Treatment Study |
| NCT02972112 | Not specified | UNKNOWN | Ultrashort Cognitive Behavioral Intervention for Tokophobia- A Prospective Randomized Single Blinded Controlled Trial |
| NCT03031002 | Not specified | COMPLETED | Extinction Generalization in Exposure Therapy |
| NCT03095482 | Not specified | COMPLETED | tDCS-Augmented Exposure Therapy for Pathological Fear |
| NCT03105024 | Not specified | COMPLETED | Self-efficacy Enhancement and Exposure Therapy |
| NCT03206437 | Not specified | COMPLETED | Effect of Mindfulness Meditation on Physiological Response to Unpredictable Stimuli |
| NCT03208400 | Not specified | COMPLETED | Virtual Reality Exposure in Spider Phobia |
| NCT03233113 | Not specified | COMPLETED | The Effects of Safety Seeking Behaviors During Exposure Therapy for Adults With Spider Phobia |
| NCT03505437 | Not specified | COMPLETED | Effects of Stress on Exposure Therapy |
| NCT03688360 | Not specified | COMPLETED | Facing Fears In-session or Out-session? |
| NCT03688373 | Not specified | COMPLETED | Facing Fears in Big or Smalls Steps? |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CYCLOSERINE | 4 | 2 |
| LEVCYCLOSERINE | 2 | 2 |
Related Atlas pages
- Drugs: Cycloserine