Spinal cord neoplasm

Summary

Spinal cord neoplasm (MONDO:0021234) is a cancer (an umbrella term covering 8 Mondo subtypes) and 19 clinical trials. Top therapeutic interventions include esketamine, lomustine, and pregabalin. A subtype of spinal cord disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Umbrella term: 8 Mondo subtypes
• Clinical trials: 19

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	spinal cord neoplasm
Mondo ID	MONDO:0021234
EFO	EFO:0003828
MeSH	D013120
NCIT	C3381
UMLS	C0037930
MedGen	11551
Anatomy (UBERON)	UBERON:0002240
Is cancer (heuristic)	yes

Also known as: neoplasm of spinal cord · neoplasm of the spinal cord · spinal cord neoplasm (disease) · spinal cord tumor · spinal cord tumour · tumor of spinal cord · tumor of the spinal cord · tumour of spinal cord · tumour of the spinal cord

Disease family

This is a subtype of spinal cord disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › spinal cord disorder › spinal cord neoplasm

Related subtypes (9): vascular myelopathy, myelitis, anterior horn disorder, tethered spinal cord syndrome, spina bifida, syringomyelia, radiation myelitis, spinal cord injury, segmental spinal dysgenesis

Subtypes (8): spinal meningioma, neurofibroma of spinal cord, childhood spinal cord tumor, conus medullaris neoplasm, cervicomedullary junction neoplasm, spinal cord cancer, spinal cord dermoid cyst, benign neoplasm of spinal cord

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

No approved or late-stage (phase ≥3) drug is indicated for this disease; the following are in earlier-phase trials only.

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Lomustine, Temozolomide.

Clinical trials & evidence

Clinical trials

Clinical trials: 19.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	15
PHASE2	2
PHASE2/PHASE3	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05096468	PHASE2/PHASE3	COMPLETED	Esketamine Combined With Pregabalin on Acute Postoperative Pain in Patients Undergoing Resection of Spinal Neoplasms.
NCT00100802	PHASE2	COMPLETED	Radiation Therapy, Temozolomide, and Lomustine in Treating Young Patients With Newly Diagnosed Gliomas
NCT00826241	PHASE2	COMPLETED	Dose-Dense Temozolomide + Lapatinib for Recurrent Ependymoma
NCT06357377	PHASE1	NOT_YET_RECRUITING	A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors
NCT05023772	Not specified	RECRUITING	Laser Interstitial Thermal Ablation and Stereotactic Radiosurgery for Patients With Spine Metastases
NCT05957679	Not specified	RECRUITING	MRE Evaluation for Spinal Cord Tumor Surgery: Stiffness and Adhesion Assessment
NCT06042946	Not specified	RECRUITING	Microsurgical Resection of Intramedullary Spinal Cord Metastases
NCT07066475	Not specified	RECRUITING	A Registry-Based Cohort Study on the Clinical Outcomes of Spinal Cord Glioma Resection Via the Dorsolateral Sulcus Approach
NCT07488702	Not specified	ACTIVE_NOT_RECRUITING	Intradurale Spinal Tumors: Management and Treatment
NCT00430872	Not specified	COMPLETED	Development of the MDASI-Spine Tumor Module
NCT00974623	Not specified	TERMINATED	Bone Graft Materials Observational Registry
NCT02494622	Not specified	COMPLETED	Alternative Treatment of Giant Spinal Schwannomas
NCT02603874	Not specified	UNKNOWN	The Development of a Vertebra Localizing Aid Medical Device
NCT03593330	Not specified	TERMINATED	Neurosurgical Transitional Care Programme
NCT04219969	Not specified	COMPLETED	FDG PET-MRI for the Diagnosis of Spinal Cord Lesions
NCT04331431	Not specified	COMPLETED	Outcomes of the Intradural Extramedullary Tumors Resection
NCT04533919	Not specified	WITHDRAWN	Validation of Pre-clinical Nano-Based Analgesics in Cells From Human Dorsal Root Ganglia
NCT04968730	Not specified	UNKNOWN	Establishment and Application of Early Postoperative Activity Plan for Patients After Hemi-laminectomy for Lumbar Spinal Tumor Resection
NCT05678608	Not specified	UNKNOWN	Surgical Outcome of Dorsolumbar Intradural Extramedullary Spinal Cord Tumors

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ESKETAMINE	4	1
LOMUSTINE	4	1
PREGABALIN	4	1
PERILLYL ALCOHOL	2	1