Spinal injury
diseaseOn this page
Also known as injury of vertebral columnvertebral column injury
Summary
Spinal injury (MONDO:0037747) is a disease and 24 clinical trials. Top therapeutic interventions include fentanyl hydrochloride, tranexamic acid, and .beta.-hydroxyisovaleric acid. A subtype of injury — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 24
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | spinal injury |
| Mondo ID | MONDO:0037747 |
| MeSH | D013124 |
| SNOMED CT | 262521009 |
| Anatomy (UBERON) | UBERON:0001130 |
| Is cancer (heuristic) | no |
Also known as: injury of vertebral column · vertebral column injury
Disease family
This is a subtype of injury. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: injury › spinal injury
Related subtypes (9): ischemia reperfusion injury, bone fracture, acute lung injury, radiation injury, burn, ankle injury, nervous system injury, frostbite, head injury
Subtypes (2): spinal fracture, spinal cord injury
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 24.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 22 |
| PHASE4 | 1 |
| PHASE2/PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT03021083 | PHASE4 | WITHDRAWN | IONSYS Feasibility Study |
| NCT02314988 | PHASE2/PHASE3 | RECRUITING | Tranexamic Acid to Reduce Blood Loss in Spine Surgery |
| NCT02170155 | Not specified | RECRUITING | MRI-changes in Morphometry and Cerebro Spinale Fluid (CSF) Flow in Spinal Cord Disorders |
| NCT00163826 | Not specified | COMPLETED | Spinal Clearance Study: Expediting the Spinal Clearance Process in the Major Trauma Patient |
| NCT00266929 | Not specified | COMPLETED | Treatment of Type II Odontoid Fractures Among the Elderly |
| NCT00289393 | Not specified | UNKNOWN | Response Shift in Patient Expectations and Functional Outcome |
| NCT00387829 | Not specified | TERMINATED | DuraGen Plus® Adhesion Barrier for Use in Spinal Surgery |
| NCT01592435 | Not specified | COMPLETED | Carestream Digital Radiography Long Length Imaging Software Data Collection Protocol |
| NCT01840397 | Not specified | COMPLETED | Neuromarker S-100B as Diagnostic Tool |
| NCT02382887 | Not specified | COMPLETED | Comparison by Neuromonitoring of Two Techniques of Tracheal Intubation in Patients With Unstable Cervical Spine |
| NCT02705690 | Not specified | UNKNOWN | Benchmarking the iOS Balance Application Against the Berg Balance Test |
| NCT02767427 | Not specified | COMPLETED | The Value of Home Chlorhexidine Pre-Surgical Wash Before Spine Surgery |
| NCT02776930 | Not specified | COMPLETED | Predictive Models for Spine and Lower Extremity Injury After Discharge From Rehab |
| NCT02886260 | Not specified | UNKNOWN | Establishing a Descriptive Cohort of Patients Cared for Operation on the Spine |
| NCT02950532 | Not specified | COMPLETED | Posterior Ligament Complex Assessment Without Magnetic Resonance Image in Thoracolumbar Fractures |
| NCT03118063 | Not specified | COMPLETED | Comparison of the Strength of Maximum Glute and Medium Glutenum Muscles Of Latin and Active Lombar Guidelines |
| NCT03660540 | Not specified | WITHDRAWN | Spine and Tumor Screening and Supplementation |
| NCT03751306 | Not specified | UNKNOWN | Aerobic Exercise and Transcranial Low Laser Therapy in Patients With Central Nervous System Injury |
| NCT04325165 | Not specified | WITHDRAWN | DBS of PPN to Improve Walking in Chronic SCI Patients |
| NCT04396613 | Not specified | COMPLETED | Wound Closure Techniques in Primary Spine Surgery |
| NCT05530798 | Not specified | COMPLETED | CEUS For Intraoperative Spinal Cord Injury |
| NCT05597176 | Not specified | COMPLETED | Telemonitored Exercise to Attenuate Metabolic Dysregulation in Spinal Cord Injury |
| NCT07265310 | Not specified | COMPLETED | Pre-therapeutic Value of Emergency Spine MRI in Patients With Thoraco-lumbar Spine Injuries - A Prospective Study. |
| NCT07354178 | Not specified | COMPLETED | Study of Collagen-Based Thrombin Hemostat for the Control of Bleeding in Spinal Surgery |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| FENTANYL HYDROCHLORIDE | 4 | 1 |
| TRANEXAMIC ACID | 4 | 1 |
| .BETA.-HYDROXYISOVALERIC ACID | 3 | 1 |
Related Atlas pages
- Drugs: Fentanyl, Tranexamic Acid