Spontaneous intracranial hypotension
disease diseaseOn this page
Also known as spontaneous cerebrospinal fluid leak
Summary
Spontaneous intracranial hypotension (MONDO:0018624) is a disease and 9 clinical trials. A subtype of headache disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: 1-9 / 100 000 (Worldwide) [Orphanet-validated]
- Clinical trials: 9
Clinical features
Epidemiology
Prevalence records
1 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Annual incidence | 1-9 / 100 000 | 5 | Worldwide | Validated |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | spontaneous intracranial hypotension |
| Mondo ID | MONDO:0018624 |
| Orphanet | 443180 |
| ICD-11 | 1304151002 |
| UMLS | C0751731 |
| MedGen | 155914 |
| GARD | 0021854 |
| NORD | 1901 |
| Is cancer (heuristic) | no |
Also known as: spontaneous cerebrospinal fluid leak
Disease family
This is a subtype of headache disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › neurological pain disorder › headache disorder › spontaneous intracranial hypotension
Related subtypes (3): hypnic headache, reversible cerebral vasoconstriction syndrome, exertional headache
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 9.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 9 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05922514 | Not specified | RECRUITING | A Clinical Registry of Spontaneous Intracranial Hypotension |
| NCT06374524 | Not specified | RECRUITING | Greater Occipital Nerve Block for Spontaneous Intracranial Hypotension |
| NCT06805591 | Not specified | ENROLLING_BY_INVITATION | Pathophysiology and Treatment of Cerebrospinal Hypotension Exploration Study |
| NCT07085260 | Not specified | NOT_YET_RECRUITING | ONSD Changes and Treatment Response After Epidural Blood Patch in Spontaneous Intracranial Hypotension |
| NCT07582744 | Not specified | NOT_YET_RECRUITING | CVFs in SIH: EID vs. PCD CTM |
| NCT07602556 | Not specified | NOT_YET_RECRUITING | Autologous Platelet-rich Plasma Versus Whole Blood for Epidural Patch in Spontaneous Intracranial Hypotension |
| NCT02261792 | Not specified | COMPLETED | Spontaneous Intracranial Hypotension Treatment SIHT |
| NCT02603549 | Not specified | SUSPENDED | Pituitary Function and Spontaneous Intracranial Hypotension |
| NCT07283536 | Not specified | WITHDRAWN | Blind Versus Targeted Epidural Patch With Autologous Platelet-rich Plasma for Spontaneous Intracranial Hypotension |
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.